Changes in trace elements and metallothioneins levels and their relationship with clinical, biochemical, and inflammatory parameters in patients with COVID-19 during the early ICU phase

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Апрель 4, 2023

Abstract Background The levels of trace elements and Metallothioneins (MTs) could play a key role in modulating the inflammatory reaction pathogenesis COVID-19. Their effects on clinical variables are interest for characterization management this disease. Thus, present study aimed to investigate association between circulating Iron (Fe), Zinc (Zn), Copper (Cu), Manganese (Mn), MTs levels, as well their relationship with clinical, biochemical, parameters critical care patients COVID-19 at early Intensive Care Unit (ICU) phase. Methods A total 86 critically ill were monitored from first day admission ICU until third stay. Clinical retrieved hospital database. Biochemical analyzed following enzymatic colorimetry immunoassay procedures. Serum samples used assess mineral by inductively coupled plasma-mass spectrometry differential pulse voltammetric. Results Levels Cu decreased (all P ≤ 0.046) after 3 days stay, increasing prevalence deficient values 50–65.3% (P = 0.015) Fe Zn shown have predictive value mortality severity. Changes directly related changes Mn r ≥ 0.266; 0.019). In contrast, inversely albumin r≥–0.255; 0.039). Conclusions indicated risk element deficiencies different biochemical parameters. We suggest monitoring status performing nutritional interventions, when appropriate, that help improve altered parameters, such conditions and, thus, prognosis

Язык: Английский

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Association of Trace Element Levels with Outcomes in Critically Ill COVID-19 Patients

Nutrients, Год журнала: 2023, Номер 15(15), С. 3308 - 3308

Опубликована: Июль 26, 2023

The primary objective of this study was to compare the plasma levels copper, selenium, and zinc between critically ill COVID-19 patients less severe patients. secondary investigate association these trace element with adverse outcomes, including duration mechanical ventilation, occurrence septic shock, mortality in All admitted ICU Geneva University Hospitals 9 March 2020 19 May were included study. Plasma selenium measured on admission compared hospitalized ward non-hospitalized To analyze elements clinical multivariate linear logistic regressions performed. Patients had significantly lower higher copper In patients, tended be associated more shock increased those (p = 0.07 for both). Having or a longer time under ventilation 0.01 0.04, respectively). These associations remained significant analyses 0.03 p 0.04 selenium). data support need interventional studies assess potential benefit zinc, supplementation

Язык: Английский

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Evolution of Status of Trace Elements and Metallothioneins in Patients with COVID-19: Relationship with Clinical, Biochemical, and Inflammatory Parameters

Metabolites, Год журнала: 2023, Номер 13(8), С. 931 - 931

Опубликована: Авг. 9, 2023

The inflammatory reaction and pathogenesis of COVID-19 may be modulated by circulating trace elements (Iron (Fe), Zinc (Zn), Copper (Cu), Manganese (Mn)) Metallothioneins (MTs). Thus, the present study aimed to investigate their relationship with clinical, biochemical, parameters in patients at early Intensive Care Unit (ICU) phase. Critically ill (n = 86) were monitored from first day ICU admission until third stay. Serum samples used assess mineral levels via Inductively Coupled Plasma Mass Spectrometry (ICP-MS) MT differential pulse voltammetry. Levels Cu MTs significantly decreased after 3 days (p < 0.05), increasing prevalence Cu-deficient values 50% 65.3% 0.015). Fe Zn shown have a predictive value for mortality severity. suggests element deficiency risk factor during treatment COVID-19, as it is related different biochemical clinical parameters, indicating possible beneficial effect restoring proper these micronutrients.

Язык: Английский

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Vitamin-mineral complexes to help adult patients frequently suffering with acute respiratory viral infections: A review

Consilium Medicum, Год журнала: 2024, Номер 26(03), С. 164 - 171

Опубликована: Май 18, 2024

Acute respiratory viral infections are widespread diseases, poorly controlled and characterized by moderately pronounced constant growth. The use of vitamin-mineral complexes (nutraceuticals) for nonspecific prevention treatment acute is experiencing a “second youth” thanks to new data accumulated during the novel coronavirus infection (COVID-19) pandemic. As part review, we examined possible impact deficiency microelements selenium zinc, vitamins A, E C on various aspects course ARVI: prevention, rehabilitation. We searched relevant sources in PubMed Scopus information databases, including time period up 04.07.2024. presence arsenal practicing physician 2 forms complex Selzinc® at outpatient stage medical care will increase effectiveness ARVI pre-epidemic period, especially “frequently ill adults with ARVI,” as well adjuvant therapy subsequent

Язык: Английский

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Determination of prognostic markers for COVID-19 disease severity using routine blood tests and machine learning

Anais da Academia Brasileira de Ciências, Год журнала: 2024, Номер 96(2)

Опубликована: Янв. 1, 2024

The need for the identification of risk factors associated to COVID-19 disease severity remains urgent. Patients' care and resource allocation can be potentially different are defined based on current classification severity. This is analysis clinical parameters routine blood tests, which not standardized across globe. Some laboratory test alterations have been severity, although these data conflicting partly due methodologies used studies. study aimed construct validate a prediction model using machine learning (ML). Seventy-two patients admitted Brazilian hospital diagnosed with through RT-PCR and/or ELISA, varying degrees were included in study. Their electronic medical records results from daily tests develop ML predict Using above set, combination five laboratorial biomarkers was identified as accurate predictors severe ROC-AUC 0.80 ​±​ 0.13. Those prothrombin activity, ferritin, serum iron, ATTP monocytes. application devised may help rationalize decision care.

Язык: Английский

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Phytonutrient Formulation Using Gum Arabic and Adansonia Digitata Pulp: Lessons for Boosting the Human Immune System - Part 1

Phytomedicine Plus, Год журнала: 2024, Номер unknown, С. 100663 - 100663

Опубликована: Окт. 1, 2024

Язык: Английский

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