Mytilus galloprovincialis: A valuable bioindicator species for understanding the effects of diclofenac under warming conditions DOI Creative Commons
Federica Arrigo, Lucia De Marchi, Valentina Meucci

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 946, С. 173809 - 173809

Опубликована: Июнь 5, 2024

Drugs are chemical compounds used to treat and improve organic dysfunctions caused by diseases. These include analgesics, antibiotics, antidepressants, antineoplastics. They can enter aquatic environments through wastewater streams, where their physico-chemical properties allow metabolites distribute accumulate. Current climate change associated extreme weather events may significantly impact these substances' toxicity organisms' sensitivity. Among the chemicals present in is non-steroidal anti-inflammatory drug diclofenac (DIC), which EU monitors due its concentration levels. This study investigated influence of temperature (control at 17 °C vs. 21 °C) on effects DIC (0 μg/L 1 μg/L) mussel species Mytilus galloprovincialis. Significant results were observed between °C. Organisms exposed higher showed a decrease several parameters, including metabolic capacity detoxification, particularly with prolonged exposure. However, some after days, M. galloprovincialis no differences from control, indicating adaptation stress. The this confirm that concentrations environment, when combined increased temperatures, produce oxidative stress adversely affect biochemical physiological performance. also validates as bioindicator for assessing environmental contamination DIC. Beyond direct organisms, presence pharmaceuticals like environment highlights interconnectedness human, animal, ecosystem health, underscoring One Health approach understanding mitigating pollution.

Язык: Английский

Characterization of microplastics and its pollution load index in freshwater Kumaraswamy Lake of Coimbatore, India DOI

Davis Ephsy,

Selvaraju Raja

Environmental Toxicology and Pharmacology, Год журнала: 2023, Номер 101, С. 104207 - 104207

Опубликована: Июнь 28, 2023

Язык: Английский

Процитировано

32
Cellular and oxidative stress responses of Mytilus galloprovincialis to chlorpromazine: implications of an antipsychotic drug exposure study DOI Creative Commons
Federica Impellitteri, Kateryna Yunko, Viktoria Martyniuk

и другие.

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Сен. 13, 2023

Introduction: Bivalve molluscs like Mytilus galloprovincialis are valuable bioindicators due to their filter-feeding lifestyle, wide distribution, and ability concentrate xenobiotics. Studying the effects of pharmaceuticals on these is crucial given presence in surface waters. This study investigated response M. chlorpromazine (Cpz), an antipsychotic with antiviral activity against influenza, HIV, coronaviruses human cells. Methods: In this study, we examined 14-day impact (Cpz) model species at two concentrations (Cpz 1: 12 ng L-1 or 37 pM; Cpz 2: µg nM). To ensure controlled exposure, a stock solution was prepared introduced into tanks match intended concentrations. Seawater solutions were refreshed every 48 h. The primary focus centered evaluating cell viability, volume regulation, oxidative stress indicators. Results: Although as assessed by decreasing regulatory Regulation decrease, did not show statistically significant changes during experiment, digestive other hand, showed decrease (p < 0.01) 2 group, suggesting general health survival Biochemically, both 1 2, superoxide dismutase increased, while catalase (CAT) decreased, causing elevated lipid peroxidation thiobarbituric acid-reactive substances protein carbonyls, particularly group. level reduced glutathione (GSH) increased exposures, whereas GSSG only Consequently, GSH/GSSG ratio group only. Discussion: A comparison magnitudes anti- pro-oxidative manifestations indicated shift exposures. These findings that induces non-specific symptoms biochemical cellular disturbances even low picomolar concentration.

Язык: Английский

Процитировано

27
Evaluation of single and combined effects of mancozeb and metalaxyl on the transcriptional and biochemical response of zebrafish (Danio rerio) DOI Creative Commons
Mahdi Banaee,

Shiva Sagvand,

Antoni Sureda

и другие.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2023, Номер 268, С. 109597 - 109597

Опубликована: Март 6, 2023

Mancozeb and metalaxyl are fungicidal agents frequently used in combination to control fungi crops that may affect non-target organisms when entering ecosystems. This study aims evaluate the environmental effects of (MAN) Metalaxyl (MET), alone combination, on zebrafish (Danio rerio) as an experimental model. The oxidative stress biomarkers transcription genes involved detoxification were assessed after co-exposure MAN (0, 5.5, 11 μg L-1) MET 6.5, 13 mg for 21 days. Exposure induced a significant increase expression related mechanisms (Ces2, Cyp1a, Mt2). Although Mt1 gene increased fish exposed L-1 combined with MET, was down-regulated significantly other groups (p < 0.05). exposure both fungicides showed synergistic levels manifested mainly at highest concentration. 0.05) alkaline phosphatase (ALP) transaminases (AST ALT), catalase activities, total antioxidant capacity, malondialdehyde (MDA) contents hepatocytes detected, lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT) hepatic glycogen content decreased Overall, these results emphasize can synergistically (except Mt2) biochemical indicators zebrafish.

Язык: Английский

Процитировано

25
Individual and Combined Toxic Effects of Nano-ZnO and Polyethylene Microplastics on Mosquito Fish (Gambusia holbrooki) DOI Open Access
Mahdi Banaee, Amir Zeidi, Reshma Sinha

и другие.

Water, Год журнала: 2023, Номер 15(9), С. 1660 - 1660

Опубликована: Апрель 24, 2023

The omnipresence of microplastics and nanoparticles has led to their entry into the fresh marine aquatic systems affected biota. present study aims evaluate impact interaction polyethylene microplastic (PE-MPs) zinc oxide (ZnO-NPs) in mosquito fish, Gambusia holbrooki. For this, fish were exposed 100 µg L−1 PE-MPs (group 2), 200 3), 50 ZnO-NPs 4), combined with 5), 6) control 1) for 14 days. assessment was made through accumulation studies (MPs Zn) antioxidant assay. Significant elevation activity catalase, superoxide dismutase, glutathione peroxidase, reductase levels observed alone combination (100 L−1) groups only. High malondialdehyde all groups. Concordantly total (TAN) displayed a significant reduction treated compared control. Accumulation on suggested liver-targeted PE-MPs, while ZnO-NPs, assisted accumulation. affirms induction oxidative stress ZnO-NPs-induced toxicity facilitated by fish.

Язык: Английский

Процитировано

24
Toxicity of cigarette butts (CBs) leachate on Nile tilapia (Oreochromis niloticus): Blood biochemical parameters, oxidative stress biomarkers, and metabolic profile DOI Creative Commons
Mahdi Banaee,

Amal Beitsayah,

Amir Zeidi

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 279, С. 116514 - 116514

Опубликована: Май 28, 2024

The aim of this study is to evaluate the toxic effects different concentrations cigarette butt leachate (CBL) (0.0, 0.5, 1, 1.5, and 2.0 µL L

Язык: Английский

Процитировано

17
The odd couple: Caffeine and microplastics. Morphological and physiological changes in Mytilus galloprovincialis DOI Creative Commons
Federica Impellitteri, Marilena Briglia, Caterina Porcino

и другие.

Microscopy Research and Technique, Год журнала: 2024, Номер 87(5), С. 1092 - 1110

Опубликована: Янв. 22, 2024

Abstract In recent years, the presence of pharmaceuticals and microplastics (MPs) in aquatic ecosystems has raised concerns about their environmental impact. This study explores combined effects caffeine, a common pharmaceutical pollutant, MPs on marine mussel Mytilus galloprovincialis . Caffeine, at concentrations 20.0 μg L −1 , (1 mg 35–50 μm size range), was used to mimic real‐world exposure scenarios. Two hundred M. specimens were divided into four groups: MPs, Mix (caffeine + MPs), Control. After two‐week acclimation period, mollusks subjected these pollutants oxygen‐aerated aquariums under controlled conditions for 14 days. Histopathological assessments performed evaluate gill morphology. Cellular volume regulation digestive gland cell viability also analyzed. Exposure caffeine induced significant morphological changes gills, including cilia loss, ciliary disk damage, cellular alterations. The chitinous rod supporting filaments suffered potentially due MP interactions, leading hemocyte infiltration filament integrity compromise. Hemocytic aggregation suggested an inflammatory response caffeine. addition, cells revealed potential damage membranes function, with impaired regulation, particularly group, raising nutrient metabolism disruption organ function These findings underscore vulnerability emphasize need monitoring mitigation efforts. Research Highlights synergy warrants investigation. could affect morphology Caffeine‐exposed had lower than control group NR retention test. mix‐exposed struggled recover volume.

Язык: Английский

Процитировано

14
Understanding and addressing microplastic pollution: Impacts, mitigation, and future perspectives DOI Creative Commons

Rajesh Debnath,

Gora Shiva Prasad,

Adnan Amin

и другие.

Journal of Contaminant Hydrology, Год журнала: 2024, Номер 266, С. 104399 - 104399

Опубликована: Июль 17, 2024

Improper disposal of household and industrial waste into water bodies has transformed them de facto dumping grounds. Plastic debris, weathered on beaches degrades micro-particles releases chemical additives that enter the water. Microplastic contamination is documented globally in both marine freshwater environments, posing a significant threat to aquatic ecosystems. The small size these particles makes susceptible ingestion by low trophic fauna, trend expected escalate. Ingestion leads adverse effects like intestinal blockages, alterations lipid metabolism, histopathological changes intestine, contributing extinction vulnerable species disrupting ecosystem balance. Notably, microplastics (MPs) can act as carriers for pathogens, potentially causing impaired reproductive activity, decreased immunity, cancer various organisms. Studies have identified seven principal sources MPs, including synthetic textiles (35%) tire abrasion (28%), highlighting human contribution this pollution. This review covers aspects microplastic pollution, sources, extraction methods, its profound impact Additionally, it explores preventive measures, aiming guide researchers selecting techniques inspiring further investigation far-reaching impacts fostering effective solutions environmental challenge.

Язык: Английский

Процитировано

13
Understanding the sources, fate and effects of microplastics in aquatic environments with a focus on risk profiling in aquaculture systems DOI
Naveed Nabi, Ishtiyaq Ahmad, Adnan Amin

и другие.

Reviews in Aquaculture, Год журнала: 2024, Номер 16(4), С. 1947 - 1980

Опубликована: Июнь 19, 2024

Abstract The upsurge in the usage of plastics on a global scale has led to widespread occurrence microplastics (MPs) aquatic environments. This review starts by outlining current scenario plastic production. It then delves into various sources and their entry systems, including impact fisheries aquaculture sector. detailed analysis methods degradation small sized, MPs followed transport, uptake trophic transference have been reviewed systematically. Besides, summarizes knowledge impacts MPs, additives associated contaminants organisms living environment, particularly fish thriving cultured conditions. effects alone association with other like heavy metals, organic pollutants leachates reveal serious such as cytotoxicity, immune response, oxidative stress, neurotoxicity, barrier attributes genotoxicity among species particularly, fish. In addition, present discusses invasion explores risk assessment both terms exposure toxicological risks biochemical nature, size, shape concentration MPs. management strategies future prospective control hazards also highlighted. summary, outlines sources, fate, environment highlighting need recognize pollution threat formulate prevention, reduce, reuse safe disposal material.

Язык: Английский

Процитировано

11
Potential synergistic effects of microplastics and zinc oxide nanoparticles: biochemical and physiological analysis on Astacus leptodactylus DOI
Mahdi Banaee, Amir Zeidi, Amin Gholamhosseini

и другие.

Ecotoxicology, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Язык: Английский

Процитировано

1
Exploring the combined interplays: Effects of cypermethrin and microplastic exposure on the survival and antioxidant physiology of Astacus leptodactylus DOI Creative Commons
Nima Shiry,

Paria Darvishi,

Amin Gholamhossieni

и другие.

Journal of Contaminant Hydrology, Год журнала: 2023, Номер 259, С. 104257 - 104257

Опубликована: Окт. 21, 2023

Plastic waste and micro/nanoplastic particles pose a significant global environmental challenge, along with concerns surrounding certain pesticides' impact on aquatic organisms. This study investigated the effects of microplastic (MPPs) cypermethrin (CYP) crayfish, focusing biochemical indices, lipid peroxidation, oxidative stress, hematological changes, histopathological damage. After determining LC

Язык: Английский

Процитировано

21