Developmental Programming: Sex-specific Effects of Prenatal Exposure to a Real-Life Mixture of Environmental Chemicals on Liver Function and Transcriptome in Sheep.

Environmental Pollution, Год журнала: 2025, Номер 367, С. 125630 - 125630

Опубликована: Янв. 5, 2025

Язык: Английский

---

Sexually dimorphic cardiovascular impacts of prenatal exposure to a real-life environmental chemical mixture in adult offspring

Environmental Toxicology and Pharmacology, Год журнала: 2025, Номер unknown, С. 104669 - 104669

Опубликована: Март 1, 2025

Язык: Английский

---

Biosolids and male reproduction

Reproduction, Год журнала: 2024, Номер 168(2)

Опубликована: Июнь 7, 2024

Over the past 50 years, there has been a concerning decline in male reproductive health and an increase infertility which is now recognised as major concern globally. While can be linked to some genetic lifestyle factors, these do not fully explain rate of declining health. Increasing evidence from human animal studies suggests that exposure chemicals found ubiquitously environment may part play role. Many on chemical exposure, however, have assessed effects individual environmental (ECs), usually at levels relevant everyday exposure. There need for study models reflect 'real-life' nature EC One such model biosolids-treated pasture (BTP) sheep utilises biosolids application agricultural land examine low-level mixtures chemicals. Biosolids are by-product treatment wastewater industrial domestic sources so their composition reflective ECs humans exposed. last 20 BTP published multiple offspring physiology including consistent system fetal, neonatal, juvenile, adult offspring. This review focuses strongly during gestation alter several components highlights more real-life effects.

Язык: Английский

---

Preconceptional and in utero exposure of sheep to a real‐life environmental chemical mixture disrupts key markers of energy metabolism in male offspring

Journal of Neuroendocrinology, Год журнала: 2023, Номер 36(1)

Опубликована: Дек. 12, 2023

Over recent decades, an extensive array of anthropogenic chemicals have entered the environment and been implicated in increased incidence diseases, including metabolic syndrome. The ubiquitous presence these environmental (ECs) necessitates use real-life exposure models to assess cumulative risk burden health. Sheep that graze on biosolids-treated pastures are exposed a mixture ECs such as phthalates, per- polyfluoroalkyl substances, heavy metals, pharmaceuticals, pesticides, metabolites thereof, this EC can result disorders their offspring. Using model, we evaluated effects gestational complex plasma triglyceride (TG) concentrations epigenetic regulatory genes tissues key energy regulation storage, hypothalamus, liver, adipose depots 11-month-old male Our results demonstrated binary effect gene expression particularly hypothalamus. Principal component analysis revealed two subsets (B-S1 [n = 6] B-S2 4]) within biosolids group (B, n 10), relative controls (C, 11). Changes body weight, TG levels, visceral subcutaneous fat were apparent between biosolid control subgroups animals. These findings demonstrate differential processes adult Binary hypothalamic altered lipid metabolism fat, coupled with phenotypic outcomes, point differences individual susceptibility could predispose vulnerable individuals later dysfunction.

Язык: Английский

---

In-utero exposure to real-life environmental chemicals disrupts gene expression within the hypothalamo-pituitary-gonadal axis of prepubertal and adult rams.

Environmental Research, Год журнала: 2024, Номер 264, С. 120303 - 120303

Опубликована: Ноя. 5, 2024

Язык: Английский

---