Insight on cytotoxic NHC gold(I) halide complexes evaluated in multifaceted culture systems

Current Research in Toxicology, Год журнала: 2024, Номер 6, С. 100174 - 100174

Опубликована: Янв. 1, 2024

Gold complexes can be a useful system in the fight against cancer. Although many studies have been carried out on vitro 2D cell culture models embryotoxic assays are particularly lacking. Embryotoxicity and DNA damage critical concerns drug development. In this study, effects of new N-Heterocyclic carbene (NHC)-Au compound (Bromo[1,3-di-4-methoxybenzyl-4,5-bis(4-methoxyphenyl)imidazol-2-ylidene]gold(I)) at different concentrations were explored using multifaceted approach, encompassing cancer cultures,

Язык: Английский

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Comparative Study of Condensed and Hydrolysable Tannins during the Early Stages of Zebrafish Development

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7063 - 7063

Опубликована: Июнь 27, 2024

In this study, we present data on the effects of condensed tannins (CTs) and hydrolysable (HTs), polyphenols extracted from plants, at different concentrations zebrafish development to identify range with toxic effects. Zebrafish embryos were exposed CTs HTs two concentration ranges (5.0-20.0 μgL-1 5.0-20.0 mgL-1) for 72 h. The toxicity parameters observed up h treatment. uptake by larvae was assessed via HPLC analysis. A qRT-PCR analysis performed evaluate expressions genes cd63, zhe1, klf4, involved in hatching process zebrafish. 5.0, 10.0, 20.0 not toxic. On contrary, mgL-1, induced a delay starting 48 treatment, while showed mainly gene expression downregulation group HTs, confirming data. We believe that study is important defining optimal doses be employed application fields such as chemical industry, animal feed medical science.

Язык: Английский

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Regeneration of zebrafish retina following toxic injury

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер unknown, С. 104582 - 104582

Опубликована: Окт. 1, 2024

Язык: Английский

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Amino modifications exacerbate the developmental abnormalities of polystyrene microplastics via mitochondria-mediated apoptosis pathway in zebrafish larvae

The Science of The Total Environment, Год журнала: 2024, Номер 958, С. 178031 - 178031

Опубликована: Дек. 16, 2024

Язык: Английский

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