Life,
Год журнала:
2025,
Номер
15(1), С. 112 - 112
Опубликована: Янв. 16, 2025
The
potential
health
risks
posed
by
the
coexistence
of
nanoplastics
(NPs)
and
triclosan
(TCS)
have
garnered
significant
attention.
However,
effects
underlying
mechanisms
NPs
TCS
on
key
functional
proteins
at
molecular
level
remain
poorly
understood.
This
study
reports
effect
polystyrene
(PSNPs)
binding
to
human
serum
albumin
(HSA)
using
multispectral
methods
simulation
systems.
experimental
results
show
that
significantly
inhibits
HSA
esterase
activity,
with
exacerbating
inhibition
in
presence
PSNPs,
which
is
attributed
alteration
conformation
microenvironment
amino
acid
residues
induced
PSNPs.
Molecular
docking
site
marker
competitive
studies
indicate
predominantly
binds
I
subdomain
Sudlow
II
PSNPs
does
not
affect
sites.
Spectra
analyses
quenching
mechanism
between
belongs
static
type
change
fluorescence
type.
conformational
alterations
are
further
enhanced
indicating
enhance
making
more
accessible
provides
valuable
information
about
toxicity
case
co-exposure.
The Science of The Total Environment,
Год журнала:
2024,
Номер
933, С. 173154 - 173154
Опубликована: Май 10, 2024
Personal
Care
Products
(PCPs)
have
been
one
of
the
most
studied
chemicals
in
last
twenty
years
since
they
were
identified
as
pseudo-persistent
pollutants
by
European
Union
early
2000s.
The
accumulation
PCPs
aquatic
environment
and
their
effects
on
non-target
species
make
it
necessary
to
find
new,
less
harmful,
substances.
Polyethylene
glycol
(PEGs)
polyvinyl
alcohol
(PVAs)
are
two
polymers
that
increased
presence
composition
recent
years,
but
little
is
known
about
effect
species.
Through
embryotoxicity
tests
common
models
organisms
(Danio
rerio
Xenopus
laevis),
this
work
aims
increase
knowledge
PEGs
PVAs'
Animals
exposed
pollutant
for
96
h.
main
endpoint
(mortality,
hatching,
malformations,
heartbeat
rate)
was
recorded
every
24
significant
results
hatching
delay
Danio
both
chemicals,
malformations
(oedema,
body
changes
pigmentation
deformations
spine
tail)
D.
X.
laevis
change
rate
(decrease
or
animals
all
tested.
Environmental Research,
Год журнала:
2024,
Номер
252, С. 118951 - 118951
Опубликована: Апрель 28, 2024
Pharmaceuticals
and
Personal
Care
Compounds
(PPCPs)
are
contaminants
present
in
wastewater
the
receiving
surface
waters,
which
have
no
regulations
can
bring
on
environmental
risks.
In
this
study,
we
evaluated
presence
of
six
PPCPs
Oro
River
Sub-basin
(Colombia)
risk
associated
with
them.
We
verified
that
monitored
rivers
show
Ibuprofen,
Cephalexin
Carbamazepine;
first
ones
(Ibuprofen
cephalexin)
were
those
presented
higher
concentrations
since
they
widely
prescribed
Colombia.
Pharmaceutical
compound
downstream
treatment
plants
from
Floridablanca
than
other
monitoring
sites
being
a
significant
point
source
contamination.
This
plant
receives
hospital
discharges
city,
including
internationally
recognized
clinics
accepting
patients
different
parts
country.
The
assessment
showed
ibuprofen
impact
aquatic
organisms.
Life,
Год журнала:
2025,
Номер
15(1), С. 112 - 112
Опубликована: Янв. 16, 2025
The
potential
health
risks
posed
by
the
coexistence
of
nanoplastics
(NPs)
and
triclosan
(TCS)
have
garnered
significant
attention.
However,
effects
underlying
mechanisms
NPs
TCS
on
key
functional
proteins
at
molecular
level
remain
poorly
understood.
This
study
reports
effect
polystyrene
(PSNPs)
binding
to
human
serum
albumin
(HSA)
using
multispectral
methods
simulation
systems.
experimental
results
show
that
significantly
inhibits
HSA
esterase
activity,
with
exacerbating
inhibition
in
presence
PSNPs,
which
is
attributed
alteration
conformation
microenvironment
amino
acid
residues
induced
PSNPs.
Molecular
docking
site
marker
competitive
studies
indicate
predominantly
binds
I
subdomain
Sudlow
II
PSNPs
does
not
affect
sites.
Spectra
analyses
quenching
mechanism
between
belongs
static
type
change
fluorescence
type.
conformational
alterations
are
further
enhanced
indicating
enhance
making
more
accessible
provides
valuable
information
about
toxicity
case
co-exposure.
