Journal of Herbal Medicine, Год журнала: 2025, Номер unknown, С. 101001 - 101001
Опубликована: Фев. 1, 2025
Язык: Английский
Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 149, С. 112787 - 112787
Опубликована: Март 8, 2022
Coronavirus disease 2019 (COVID-19) is an acute respiratory infectious caused by severe syndrome coronavirus 2 (SARS-CoV-2), and it has become a public health concern worldwide. In addition to symptoms, some COVID‑19 patients also show various gastrointestinal symptoms even consider be the first manifestation. A large amount of evidence shown that SARS-CoV-2 infection could disrupt gut microbiota balance, disorders aggravate condition COVID-19 patients. Therefore, maintaining balance expected potential new therapeutic target for treating COVID-19. Traditional Chinese medicine (TCM) significant effects in all stages prevention treatment It can adjust ideal intestinal microecological regulator. This review summarizes advantages clinical efficacy TCM expounds on relationship between microbiota, mechanism induced SARS-CoV-2, cytokine storms role preventing regulating provide research ideas
Язык: Английский
Процитировано
46
Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(9), С. 3598 - 3637
Опубликована: Июнь 5, 2023
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide. Effective treatments against COVID-19 remain urgently in need although vaccination significantly reduces the incidence, hospitalization, and mortality. At present, antiviral drugs including Nirmatrelvir/Ritonavir (Paxlovid
Язык: Английский
Процитировано
31
Journal of Traditional and Complementary Medicine, Год журнала: 2022, Номер 12(1), С. 100 - 113
Опубликована: Янв. 1, 2022
The management of the worldwide spreading COVID-19 consists amelioration its symptoms but no cure is yet available. Herbal medicines supplemented with Western medicine have been applied for treatment in India, China, Iran, and other countries. This systematic review meta-analysis RCTs evaluates effect safety herbal intervention COVID-19. from databases like PubMed, Cochrane Library, ScienceDirect, Google Scholar, Science Direct, CTRI, AYUSH Research Portal, were reviewed data extracted study sample demographics, details, clinical effect, inflammatory markers monitoring. Outcomes expressed as Risk-ratio (RR) 95% CI dichotomous data, Mean-Difference (MD) continuous data. From 32 eligible studies, a total 3177 patients included review. an adjuvant to causes significantly higher improvement compared alone [Fever (RR = 1.09 1.03, 1.15), Cough (Risk-Ratio 1.22 1.08, 1.37), Fatigue 1.27 1.11, 1.44), Chest CT Improvement 1.15 1.23)]. laboratory parameters also better group standard care only WBC (MD 0.36 0.16, 0.55), Lymphocyte percentage 5.48 3.05, 7.92), Absolute lymphocyte count 0.23 0.07, 0.39), CRP −5.66 -7.96, −3.37). However, duration hospital stays −1.82 -3.84, 0.21); IL-6 −3.67 -8.76, 1.43), ESR Level −10.38 -25.96, 5.21) statistically insignificant. No significant adverse events medications noted RCTs, during time studies. (n 665, RR 0.93; 0.76, 1.14).
Язык: Английский
Процитировано
38
Frontiers in Pharmacology, Год журнала: 2022, Номер 12
Опубликована: Фев. 4, 2022
Traditional Chinese medicines (TCMs) have been regularly prescribed to treat and prevent diseases for thousands of years in the eastern part Asian continent. Thus, when coronavirus disease 2019 (COVID-19) epidemic started, TCM was officially incorporated as a strategy by National Health Commission (NHC) treatment COVID-19 infection. TCMs were used had significant effect on alleviating symptoms, delaying progression, improving cure rate, reducing mortality rate China. Therefore, China’s approved Qingfei Paidu decoction, Xuanfei Baidu Huashi Lianhua Qingwen capsules, Jinhua Qinggan granules, Xuebijing treatment. This review evaluates summarizes use against infectious composition, clinical efficacy, mechanisms NHC-approved “three three recipes” The recipes demonstrated be highly effective COVID-19, but there is lack vivo or vitro evidence. Most available data related potential mechanism based virtual simulation prediction, which acquired via molecular docking network pharmacology analysis. These predictions not yet proven. need high-quality studies employing new strategies technologies such genomics, metabolomics, proteomics verify predicted these drug’s effects COVID-19.
Язык: Английский
Процитировано
30
Frontiers in Pharmacology, Год журнала: 2021, Номер 12
Опубликована: Авг. 6, 2021
Until now, there is no clinically approved specific medicine to treat COVID-19. Prior systematic reviews (SRs) have shown that traditional Chinese (TCM) reduces the number of patients with severe disease and time fever clearance, promotes clinical effectiveness, improves chest images negativity rate acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid test. Few SRs arrived at a definitive conclusion, more randomized controlled trials (RCTs) were published. We conducted this study summarize latest evidence TCM in
Язык: Английский
Процитировано
40
Chinese Medicine, Год журнала: 2021, Номер 16(1)
Опубликована: Июль 27, 2021
An ongoing outbreak of severe respiratory illness and pneumonia caused by the acute coronavirus 2 (SARS-CoV-2) commenced in December 2019, disease was named as 2019 (COVID-19). Soon after, scientists identified characteristics SARS-CoV-2, including its genome sequence protein structure. The clinical manifestations COVID-19 have now been established; nucleic acid amplification is used for direct determination virus, whereas immunoassays can determine antibodies against SARS-CoV-2. Clinical trials several antiviral drugs are ongoing. However, there still no specific to treat COVID-19. Traditional Chinese medicine (TCM) treatment during early stages China. Some ancient TCM prescriptions, which were efficacious syndrome (SARS) 2002-03 influenza pandemic (H1N1) 2009, improved experienced practitioners based on their symptoms. These developed new prescriptions include Lianhua Qingwen capsules/granules, Jinhua Qinggan granules XueBiJing injection, among others. In this review, we summarized presenting features COVID-19, progress using TCMs.
Язык: Английский
Процитировано
38
Aging and Disease, Год журнала: 2021, Номер 12(8), С. 1850 - 1850
Опубликована: Янв. 1, 2021
When the outbreak of COVID-19 occurred in 2020, Chinese government promptly undertook a series preventive control and medical treatment measures that have effectively reduced infection mortality rates COVID-19. In process preventing transmission treating COVID-19, actively promotes use traditional medicine (TCM), studies been carried out to determine efficacy TCM for physicians accumulated rich experiences created three patent medicines (i.e., Lianhua Qingwen Capsule, Jinhua Qinggan Granules, Xuebijing Injection) herbal prescriptions Xuanfeibaidu Recipe, Huashi Paidu Qingfei Decoction), as well other strategies based on theory treat Studies reported plays significant role improving clinical symptoms, shortening duration hospitalization, reducing overall rate, obtaining favorable outcomes patients with severe disease progression, quality life immunity, positive rate viral nucleic acid testing. has fairly high degree safety, but level evidence needs be further improved.
Язык: Английский
Процитировано
35
Frontiers in Pharmacology, Год журнала: 2021, Номер 12
Опубликована: Авг. 31, 2021
Respiratory viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV)-1, SARS-CoV-2, influenza A and syncytial virus, pose a serious threat to society. Based on the guiding principles of "holism" "syndrome differentiation treatment", traditional Chinese medicine (TCM) has unique advantages in treatment virus diseases owing synergistic effect multiple components targets, which prevents drug resistance from arising. According TCM theory, there are two main strategies antiviral treatments, namely "dispelling evil" "fu zheng". Dispelling evil corresponds direct inhibition growth fu zheng immune regulation, inflammation control, tissue protection host. In this review, current progress using TCMs against viruses is summarized according modern biological theories. The prospects for developing discussed provide reference research development innovative with components, low toxicity.
Язык: Английский
Процитировано
32
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(20), С. 11078 - 11078
Опубликована: Окт. 14, 2021
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection; the pathophysiology of sepsis complex. The incidence steadily increasing, with worldwide mortality ranging between 30% and 50%. Current treatment approaches mainly rely on timely appropriate administration antimicrobials supportive therapies, but search for pharmacotherapies modulating has been unsuccessful. Chinese herbal medicines, i.e., patent prescriptions, single herbs, play an important role in through multicomponent, multipathway, multitargeting abilities have officially recommended management COVID-19. medicines therapeutic actions promising sepsis; basic scientific research these increasing. However, material bases most their underlying mechanisms action not yet fully elucidated. This review summarizes current studies used terms clinical efficacy safety, pharmacological activity, phytochemistry, bioactive constituents, action, pharmacokinetics, provide foundation clarifying pathogenesis developing novel antisepsis drugs based medicines.
Язык: Английский
Процитировано
28
JAMA Network Open, Год журнала: 2022, Номер 5(3), С. e222973 - e222973
Опубликована: Март 18, 2022
Язык: Английский
Процитировано
22