Investigative and Clinical Urology,
Год журнала:
2023,
Номер
64(1), С. 3 - 3
Опубликована: Янв. 1, 2023
The
microbiome
which
is
an
assembly
of
all
microbes
living
inside
our
bodies
performs
a
major
role
in
maintaining
human
health
and
wellness.
It
has
been
found
that
the
imbalance
can
cause
various
diseases
humans.
Similarly,
there
growing
evidence
largely
affects
person's
chance
contracting
certain
cancers
how
disease
develops
progresses.
Studies
have
shown
about
15%
to
20%
are
caused
by
microbial
pathogens.
prevalence
prostate
cancer,
increasing
rapidly
Korea,
related
lifestyle
including
diet.
These
diets
alter
gut
composition,
effect
on
cancer
development
be
estimated.
However,
associated
with
reported
differently
according
race.
This
means
metabolite
rather
than
specific
will
important.
Short
chain
fatty
acids,
metabolites
microbiome,
plays
important
action
mechanism
microbiome.
acids
play
roles
such
as
immunomodulation
inhibition
histone
deacetylase.
Here,
we
examined
most
up-to-date
literature
featuring
effects
risk
pathogenesis
cancer.
Journal of Clinical Oncology,
Год журнала:
2023,
Номер
41(17), С. 3203 - 3216
Опубликована: Апрель 27, 2023
It
remains
unknown
whether
or
not
short-term
androgen
deprivation
(STAD)
improves
survival
among
men
with
intermediate-risk
prostate
cancer
(IRPC)
treated
dose-escalated
radiotherapy
(RT).
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Окт. 23, 2023
It
is
unclear
regarding
associations
of
dietary
patterns
with
a
wide
range
chronic
diseases
and
which
score
more
predictive
major
diseases.
Using
the
UK
Biobank,
we
examine
four
individual
healthy
scores
risk
48
Higher
Alternate
Mediterranean
Diet
associated
lower
32
(all
8
cardiometabolic
disorders,
3
out
10
types
cancers,
7
psychological/neurological
5
6
digestive
9
14
other
diseases).
Healthy
Eating
Index-2010
Healthful
Plant-based
Index
are
inversely
29
23
diseases,
respectively.
A
higher
Anti-Empirical
Dietary
Inflammatory
incidence
two
Our
findings
support
guidelines
for
prevention
most
Annual Review of Medicine,
Год журнала:
2024,
Номер
75(1), С. 49 - 66
Опубликована: Янв. 29, 2024
Prostate-specific
membrane
antigen
(PSMA)
as
a
transmembrane
protein
is
overexpressed
by
prostate
cancer
(PC)
cells
and
accessible
for
binding
antibodies
or
low-molecular-weight
radioligands
due
to
its
extracellular
portion.
Successful
targeting
of
PSMA
began
with
the
development
humanized
J591
antibody.
Due
their
faster
clearance
compared
antibodies,
small-molecule
targeted
imaging
therapy
PC
have
been
favored
in
recent
efforts.
positron
emission
tomography
(PET)
has
higher
diagnostic
performance
than
conventional
initial
staging
high-risk
biochemical
recurrence
detection/localization.
However,
it
remains
be
demonstrated
how
integrate
PET
response
assessment
an
outcome
endpoint
measure
clinical
trials.
With
approval
177
Lu-PSMA-617
US
Food
Drug
Administration
metastatic
castration-resistant
progressing
after
chemotherapy,
high
value
PSMA-targeted
was
confirmed.
Compared
standard
care,
PSMA-based
radioligand
led
better
quality
life.
This
review,
focusing
on
advanced
setting,
provides
overview
different
approved
nonapproved
therapeutic
modalities
discusses
future
theranostics,
also
outlook
non-radiopharmaceutical-based
therapies.
European Journal of Nuclear Medicine and Molecular Imaging,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Abstract
Background
Prostate-specific
membrane
antigen
(PSMA)
positron
emission
tomography/computed
tomography
(PET/CT)
is
currently
under
evaluation
for
detecting
clinically
significant
prostate
cancer.
The
PSMA-PET/CT
may
complement
the
current
standard
diagnostic
pathway
cancer,
which
includes
prostate-specific
(PSA)
testing
and
multiparametric
magnetic
resonance
imaging
(mpMRI).
This
study
evaluated
cost-effectiveness
quality
of
life
impact
incorporating
into
this
algorithm.
Methods
A
life-time
decision
model
compared
care
a
MRI
driven
pathway,
where
men
undergo
biopsy
in
case
Prostate
Imaging
Reporting
Data
System
(PI-RADS)
scores
3–5,
to
strategy
potentially
avoid
unnecessary
biopsies.
Long-term
quality-adjusted
years
(QALY)
healthcare
costs
were
calculated
each
approach.
Results
In
PI-RADS
3
lesions,
improved
per-patient
QALY
by
0.002
was
borderline
cost-effective,
with
an
increased
cost
€170-€186
per
patient
incremental
ratio
(ICER)
€56,700-€93,212
QALY.
1–2,
additional
biopsies
over-detection
low-risk
cancers
led
decrease
0.001
points,
increase
€416-€429
thus
not
cost-effective.
Conclusion
addition
patients
equivocal
findings
appears
be
cost-effective
due
avoidance
reduced
detection
indolent,
tumors.
negative
MRI,
adding
does
seem
higher
number
only
minor
improvement
Cancers,
Год журнала:
2025,
Номер
17(3), С. 372 - 372
Опубликована: Янв. 23, 2025
Periprostatic
adipose
tissue
(PPAT)
contributes
to
the
pathogenesis
of
prostate
cancer.
The
purpose
this
study
was
review
and
summarize
literature
on
role
PPAT
in
cancer
pathogenesis.
Moreover,
we
evaluated
clinical
implication
patients
with
We
performed
a
scoping
PubMed
from
January
2002
November
2024.
Search
terms
included
“periprostatic
tissue”,
“adipokines”,
“prostate
cancer”.
Secondary
search
involved
reference
lists
eligible
articles.
key
criterion
identify
studies
that
PPAT,
adipokines,
their
biology
features.
In
total
225
publications
were
selected
for
inclusion
review.
contained
allowed
us
data
as
contributor
its
aggressiveness.
also
presents
new
research
directions
target
treatment
Based
current
review,
it
can
be
stated
plays
an
important
seems
promising
point
when
comes
finding
therapies
more
aggressive
and/or
advanced
stages
Genes,
Год журнала:
2025,
Номер
16(2), С. 148 - 148
Опубликована: Янв. 25, 2025
Background:
Mesoporous
titanium
dioxide
nanoparticles
(mTiNPs)
are
known
for
their
chemical
stability,
non-toxicity,
antimicrobial
and
anticancer
effects,
as
well
photocatalytic
properties.
When
this
material
is
subjected
to
UV
radiation,
its
electronic
structure
shifts,
during
that
process,
reactive
oxygen
species
generated,
which
in
turn
exert
apoptotic
events
on
the
cancer
cells.
Objectives:
We
evaluated
cytotoxic
effects
of
UV-irradiated
mTiNPs
prostate
(PCa)
cell
line
PC3
with
aim
demonstrating
interaction
between
UV-light
positively
impacts
nanomaterial’s
efficiency.
Moreover,
we
assessed
differential
expression
key
oncomiRs
tumor
suppressor
(TS)
miRNAs,
associated
target
genes,
cells
undergoing
treatment.
Methods:
PBS-suspended
exposed
290
nm
light
were
added
at
different
concentrations
Cell
viability
was
determined
after
24
h
a
crystal
violet
assay.
Then,
obtained
IC50
concentration
UV-nanomaterial
applied
new
culture,
set
miRNAs
selected
genes
via
qRT-PCR.
Results:
The
photo-activated
required
4.38
times
less
nanomaterial
than
group
non-irradiated
achieve
half-maximal
inhibition,
an
improved
performance
mTiNPs.
miR-18a-5p,
miR-21-5p,
miR-221-5p
downregulated
application
UV-mTiNPs,
while
TS
miR-200a-5p
miR-200b-5p
displayed
upregulated
expression.
Among
miRNA
PTEN
found
be
treatment,
BCL-2
TP53
underexpressed.
Conclusions:
Our
outcomes
coincided
previous
reports
performed
other
lines,
strongly
suggesting
promising
nano-therapeutic
approach
against
PCa.
On
hand,
best
our
knowledge,
first
report
exploring
impact
onco-
microRNAs
PCa
