Role of microbiome and its metabolite, short chain fatty acid in prostate cancer DOI Creative Commons
Hee Jo Yang, Jae Heon Kim

Investigative and Clinical Urology, Год журнала: 2023, Номер 64(1), С. 3 - 3

Опубликована: Янв. 1, 2023

The microbiome which is an assembly of all microbes living inside our bodies performs a major role in maintaining human health and wellness. It has been found that the imbalance can cause various diseases humans. Similarly, there growing evidence largely affects person's chance contracting certain cancers how disease develops progresses. Studies have shown about 15% to 20% are caused by microbial pathogens. prevalence prostate cancer, increasing rapidly Korea, related lifestyle including diet. These diets alter gut composition, effect on cancer development be estimated. However, associated with reported differently according race. This means metabolite rather than specific will important. Short chain fatty acids, metabolites microbiome, plays important action mechanism microbiome. acids play roles such as immunomodulation inhibition histone deacetylase. Here, we examined most up-to-date literature featuring effects risk pathogenesis cancer.

Язык: Английский

Association of cigarette use with risk of prostate cancer among US males: a cross-sectional study from NHANES 1999–2020 DOI Creative Commons
Xiangwei Yang, Hong Chen, Junfu Zhang

и другие.

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 13, 2025

Association of cigarette use with risk prostate cancer remains unclear. We performed this study to examine whether is associated increased cancer. This cross-sectional used data from the 1999 2020 National Health and Nutrition Examination Survey (NHANES), a population-based nationally representative survey designed assess health nutritional status US adults children. Males were eligible if they aged ≥ 20 years at time participation. Cigarette (ever use, categorized into former current use) was defined as having smoked least 100 cigarettes in life. Smoking duration, per day, smoking pack-years calculated smokers smokers. The primary outcome self-reported diagnosis by participants. Logistic regression calculate adjusted odd ratios (aOR) 95% CI for associations cancer, adjusting demographic characteristics. Subgroup analyses age group conducted. Data analyzed June 4 November 30, 2023. Of 107 622 participants 1999–2020 NHANES, 28 170 included analysis. mean (SD) 46.4 (16.4) years, 68.0% non-Hispanic White. Compared never smokers, ever (aOR, 2.41 [95% CI, 1.15–5.06]) 3.56 1.62–7.85]) had higher 3.82 1.69–8.64]) 2.82 1.27–6.25]) also found 20–59 years. Dose-response analysis showed positive association between duration 1.07 1.03–1.11]), day 1.03 1.00-1.07]), 1.02 1.01–1.03]) suggests that an males, especially among those Further research utilizing prospective design modeling family history needed confirm findings.

Язык: Английский

Процитировано

1
Androgens, aging, and prostate health DOI Creative Commons
Karin Welén, Jan‐Erik Damber

Reviews in Endocrine and Metabolic Disorders, Год журнала: 2022, Номер 23(6), С. 1221 - 1231

Опубликована: Июнь 24, 2022

Abstract Due to late onset hypogonadism (LOH), there is an increased usage of testosterone replacement therapy (TRT) in the aging male population. Since prostate a target organ for androgens and anti-androgenic strategies are used treat palliate benign hyperplasia (BPH) cancer (PC), prevalence both increases with age, possible influence TRT on health becomes highly relevant. The present review summarizes existing data associations between endogenous hormone concentrations growth concludes that circulating do not appear be associated risks development BPH or initiation progression PC. explanation these findings relates apparent insensitivity prostatic tissue changes within physiological range.

Язык: Английский

Процитировано

32
The Swedish national guidelines on prostate cancer, part 1: early detection, diagnostics, staging, patient support and primary management of non-metastatic disease DOI Creative Commons
Ola Bratt, Stefan Carlsson, Per Fransson

и другие.

Scandinavian Journal of Urology, Год журнала: 2022, Номер 56(4), С. 265 - 273

Опубликована: Июль 4, 2022

There is now an unprecedented amount of evidence to consider when revising prostate cancer guidelines. We believe that there a value in publishing summaries national clinical guidelines English for others read and comment on.This part 1 summary the Swedish were published June 2022. It covers early detection, diagnostics, staging, patient support management non-metastatic disease. Part 2 recurrence after local treatment metastatic disease.The 2022 include several new recommendations: rectal iodine-povidone reduce post-biopsy infections, external beam radiation with focal boost tumour, use pre-rectal spacer side effects radiotherapy some expert centres, 6 months' concomitant adjuvant rather than neoadjuvant hormonal together unfavourable intermediate high-risk disease, abiraterone plus prednisolone GnRH agonist subgroup men very The differ from European by having more restrictive recommendations regarding genetic testing pelvic lymph node dissection, risk group classification, recommending ultra-hypofractionated (7 fractions) selected cancers, not any favourable intermediate-risk bicalutamide monotherapy instead groups.The

Язык: Английский

Процитировано

32
Anticancer Potential of Natural Chalcones: In Vitro and In Vivo Evidence DOI Open Access
Radka Michalková, Ladislav Mirossay, Martin Kello

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(12), С. 10354 - 10354

Опубликована: Июнь 19, 2023

There is no doubt that significant progress has been made in tumor therapy the past decades. However, discovery of new molecules with potential antitumor properties still remains one most challenges field anticancer therapy. Nature, especially plants, a rich source phytochemicals pleiotropic biological activities. Among plethora phytochemicals, chalcones, bioprecursors flavonoid and isoflavonoids synthesis higher have attracted attention due to broad spectrum activities clinical applications. Regarding antiproliferative effects multiple mechanisms action including cell cycle arrest, induction different forms death modulation various signaling pathways documented. This review summarizes current knowledge related natural chalcones types malignancies breast cancers, cancers gastrointestinal tract, lung renal bladder melanoma.

Язык: Английский

Процитировано

21
Role of microbiome and its metabolite, short chain fatty acid in prostate cancer DOI Creative Commons
Hee Jo Yang, Jae Heon Kim

Investigative and Clinical Urology, Год журнала: 2023, Номер 64(1), С. 3 - 3

Опубликована: Янв. 1, 2023

The microbiome which is an assembly of all microbes living inside our bodies performs a major role in maintaining human health and wellness. It has been found that the imbalance can cause various diseases humans. Similarly, there growing evidence largely affects person's chance contracting certain cancers how disease develops progresses. Studies have shown about 15% to 20% are caused by microbial pathogens. prevalence prostate cancer, increasing rapidly Korea, related lifestyle including diet. These diets alter gut composition, effect on cancer development be estimated. However, associated with reported differently according race. This means metabolite rather than specific will important. Short chain fatty acids, metabolites microbiome, plays important action mechanism microbiome. acids play roles such as immunomodulation inhibition histone deacetylase. Here, we examined most up-to-date literature featuring effects risk pathogenesis cancer.

Язык: Английский

Процитировано

19