Revolutionizing Cancer Immunotherapy: Emerging Nanotechnology-Driven Drug Delivery Systems for Enhanced Therapeutic Efficacy

ACS Measurement Science Au, Год журнала: 2024, Номер 5(1), С. 31 - 55

Опубликована: Ноя. 15, 2024

Cancer immunotherapy is an innovative way of treating cancer by stimulating individual cells to overcome cancer. Widespread biomedical studies were carried out with the aim exploring therapeutics, and this review spotlights some mechanisms in which it was developed, namely immune checkpoint inhibitors (E.G PD-1/PD-L1, CTLA-4), adoptive cell therapy (e.g., CAR T-cell therapy), vaccines. Although has shown clinical benefit a number types, including melanoma non-small-cell lung cancer, several challenges have dampened enthusiasm for approach, from differing patient response rates toxicities. Nanotechnology drug delivery systems must play role overcoming same. enables increased specificity controlled release, improved solubility bioavailability, can treat tumor specifically, localized at disease site decreases systemic toxicity. The also features advances construction lipid-based, polymeric, inorganic nanoparticles that improve stability allow cotherapeutic agents. Nanotechnology-based be used alone or combination assist improving response, gaining access microenvironment, biological barriers. Thus, nano-DDS both safe effective preclinical studies, ongoing trials they are capable increasing therapeutic index anticancer drugs. Lastly, discusses current regulatory issues advancing these technologies highlights importance further research devise appropriate methodology efficient functionalization nanotechnology individualized solutions treatment.

Язык: Английский

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Targeted delivery of food functional ingredients in precise nutrition: design strategy and application of nutritional intervention

Critical Reviews in Food Science and Nutrition, Год журнала: 2023, Номер 64(22), С. 7854 - 7877

Опубликована: Март 31, 2023

With the high incidence of chronic diseases, precise nutrition is a safe and efficient nutritional intervention method to improve human health. Food functional ingredients are an important material base for precision nutrition, which have been researched their application in preventing diseases improving However, poor solubility, stability, bad absorption largely limit effect on intervention. The establishment stable targeted delivery system helpful enhance bioavailability, realize controlled release at action sites vivo, provide approaches methods nutrition. In this review, we summarized recent studies about types systems digestion fate gastrointestinal tract, including emulsion-based polymer-based systems. building materials, structure, size charge particles these were manipulated fabricate carriers. Finally, food gained some achievements inflammatory bowel disease (IBD), liver disease, obesity, cancer. These findings will help designing fine systems, achieving

Язык: Английский

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Dasatinib: a potential tyrosine kinase inhibitor to fight against multiple cancer malignancies

Medical Oncology, Год журнала: 2023, Номер 40(6)

Опубликована: Май 10, 2023

Язык: Английский

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Nanocarriers in Skin Cancer Treatment: Emerging Drug Delivery Approaches and Innovations.

Nano TransMed, Год журнала: 2024, Номер unknown, С. 100068 - 100068

Опубликована: Дек. 1, 2024

Язык: Английский

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Polymeric micelles assisted combinatorial therapy: Is it new hope for pancreatic cancer?

European Polymer Journal, Год журнала: 2022, Номер 184, С. 111784 - 111784

Опубликована: Дек. 20, 2022

Язык: Английский

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