Macromolecular Chemistry and Physics,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Abstract
Digital
light
processing
(DLP)
is
emerging
as
a
powerful
tool
for
fabricating
tissue
engineering
(TE)
scaffolds,
particularly
vascular
TE
and
the
development
of
representative
in
vitro
wall
models.
For
latter,
biomaterials
should
mimick
biological
mechanical
properties
native
blood
vessels.
To
fabricate
tubular
constructs,
DLP‐printing
process
optimized
by
exploiting
acrylate‐endcapped
urethane‐based
(AUP)
polymers
presence
acrylate
end
groups
render
them
suitable
DLP
printing
desirable
arise
from
urethane
segments.
Four
AUP
variants
are
synthesized,
exploring
polyethylene
glycol
(PEG)
polypropylene
(PPG)
backbones
with
varying
functionalities
(di‐acrylate
versus
hexa‐acrylate),
namely
UPEG2,
UPEG6,
UPPG2,
UPPG6.
Tubular
constructs
precise
dimensions
morphology
fabricated.
PPG‐based
exhibit
superior
computer‐aided
design/manufacturing
(CAD/CAM)
mimicry
compared
to
PEG‐based
derivatives.
Construct
characterization
reveals
tunable
properties,
elastic
moduli
ranging
45
259
kPa,
reaching
values
human
In
particular,
UPPG6
shows
two‐fold
higher
modulus
UPPG2.
All
materials
show
excellent
biocompatibility.
Additionally,
surface
modification
gelatin‐methacryloyl
(GELMA)
significantly
enhances
cytocompatibility
UPPG2
scaffolds.
This
study
demonstrates
feasibility
using
polymers.
Colloids and Interface Science Communications,
Год журнала:
2024,
Номер
62, С. 100797 - 100797
Опубликована: Июль 26, 2024
Adhesive
interface
stiffness
significantly
influences
physiological
processes
by
altering
cell
behaviors
and
signaling
pathways.
In
particular,
phosphoinositide
3-kinase
(PI3K)-AKT
pathway,
one
of
the
most
important
pathways
that
division,
survival,
differentiation,
can
be
affected.
However,
detailed
mechanism
this
interaction
remains
unclear.
study,
we
used
gelatin
methacrylate
(GelMA)
hydrogels
with
varying
to
mimic
cellular
mechanical
environments
examine
their
effects
on
PI3K-AKT
signaling.
Cells
cultured
stiff
showed
increased
spreading,
focal
adhesion
formation,
contractility
compared
those
softer
hydrogels.
Furthermore,
mechanotransduction
activation
upregulated
PIP3,
PI3K,
phosphorylated
AKT
(pAKT)
expression.
Notably,
inhibiting
myosin
II,
a
key
regulator
contractility,
reduced
signaling,
suggesting
link
between
force
generation
pathway
activation.
These
findings
reveal
how
mediated
through
which
provides
new
insights
for
developing
therapies
targeting
PI3K-AKT-associated
diseases.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(36), С. 47226 - 47241
Опубликована: Авг. 28, 2024
The
development
of
multifunctional
wound
adhesives
is
critical
in
clinical
settings
due
to
the
scarcity
dressings
with
effective
adhesive
properties
while
protecting
against
infection
by
drug-resistant
bacteria.
Polysaccharide
and
gelatin-based
hydrogels,
known
for
their
biocompatibility
bioactivity,
assist
healing.
This
study
introduces
a
bioadhesive
hydrogel
developed
through
dynamic
covalent
bonding
light-triggered
bonding,
comprising
oxidized
hyaluronic
acid,
methacrylated
gelatin,
bacteriocin
recently
discovered
our
lab,
named
jileicin
(JC).
adhesion
strength
hydrogel,
measured
at
180
kPa,
was
4.35
times
higher
than
that
fibrin
glue.
Furthermore,
demonstrated
robust
platelet
adhesion,
procoagulant
activity,
outstanding
hemostatic
mouse
liver
injury
model.
Incorporating
JC
significantly
enhanced
phagocytosis
bactericidal
capabilities
macrophages.
immunomodulatory
function
on
host
cells,
coupled
its
potent
bacterial
membrane-disrupting
ability,
makes
an
killer
methicillin-resistant
Staphylococcus
aureus.
In
repair
experiments
diabetic
mice
infected
full-thickness
skin
defects,
treatment
group
showed
notable
reduction
load,
accelerated
M2-type
macrophage
polarization,
diminished
inflammation,
hastened
Owing
biocompatibility,
antibacterial
controlled
this
presents
promising
therapeutic
option
treating
wounds.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
19(6), С. 100952 - 100952
Опубликована: Сен. 1, 2024
Overcoming
the
poor
physicochemical
properties
of
pure
alginate
gel
and
inherent
shortcomings
metal
organic
framework
(MOF),
alginate/
MOF
composite
has
captured
interest
many
researchers
as
a
tunable
platform
with
high
stability,
controllable
pore
structure,
enhanced
biological
activity.
Interestingly,
different
from
traditional
or
inorganic
nanofillers
physically
trapped
chemically
linked
within
neTtworks,
MOFs
crystals
can
not
only
be
dispersed
by
crosslinking
polymerization,
but
also
support
self-assembly
in-situ
under
help
chelating
cations
alginate.
The
latter
is
influenced
multiple
factors
may
involve
some
complex
mechanisms
action,
which
topic
discussed
deeply
in
this
article
while
summarizing
preparation
routes.
Furthermore,
various
physical
chemical
levels
improvement
strategies
available
macroforms
are
summarized
oriented
towards
obtaining
ideal
performance.
Finally,
application
status
system
drug
delivery,
wound
healing
other
biomedical
fields
further
discussed.
And
current
limitations
future
development
directions
shed
light
simultaneously,
provide
guidance
for
vigorous
these
systems.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 10745 - 10765
Опубликована: Окт. 1, 2024
Tissue
engineering
aims
to
recreate
natural
cellular
environments
facilitate
tissue
regeneration.
Gelatin
methacrylate
(GelMA)
is
widely
utilized
for
its
biocompatibility,
ability
support
cell
adhesion
and
proliferation,
adjustable
mechanical
characteristics.
This
study
developed
a
GelMA
graphene
bioink
platform
at
concentrations
of
1,
1.5,
2
mg/mL
enhance
scaffold
properties
applications.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(20), С. 23519 - 23531
Опубликована: Окт. 9, 2024
Traditional
wound
dressings
have
limitations
in
terms
of
their
antibacterial
and
anti-inflammatory
properties,
as
well
ability
to
maintain
a
moist
environment.
Addressing
these
deficiencies
with
innovative
biomaterials,
such
hydrogels
combined
nanomaterials,
can
accelerate
healing
perform
variety
functions
advanced
biomedical
materials.
In
this
study,
3D-printed
hydrogel
membranes
were
designed
nanofibrous
PLA
mats
produced
by
the
solution
blow
spinning
technique
(SBS)
for
use
bilayered
dressing.
These
manufactured
from
gelatin
modified
methacrylamide
groups
(GMA),
incorporated
bioactive
lignin
carbon
dots
(CDs),
cross-linked
using
ultraviolet
(UV)
light.
The
GMA
addition
CDs
showed
antimicrobial
activity
against
Staphylococcus
aureus
Escherichia
coli
greater
mechanical
deformation
when
fibrous
mats,
not
causing
cytotoxic
effects
human
fibroblasts.
Furthermore,
developed
material
was
capable
maintaining
persistent
hydrated
environment
area
adequate
degradation
capacity.
Our
results
demonstrate
potential
manufacturing
multifunctional
utilizing
biodegradable
sustainable
nanomaterials
that
are
both
cost-effective
straightforward
produce,
applications
fields,
including
treatment
skin
infections.
Macromolecular Chemistry and Physics,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Abstract
Digital
light
processing
(DLP)
is
emerging
as
a
powerful
tool
for
fabricating
tissue
engineering
(TE)
scaffolds,
particularly
vascular
TE
and
the
development
of
representative
in
vitro
wall
models.
For
latter,
biomaterials
should
mimick
biological
mechanical
properties
native
blood
vessels.
To
fabricate
tubular
constructs,
DLP‐printing
process
optimized
by
exploiting
acrylate‐endcapped
urethane‐based
(AUP)
polymers
presence
acrylate
end
groups
render
them
suitable
DLP
printing
desirable
arise
from
urethane
segments.
Four
AUP
variants
are
synthesized,
exploring
polyethylene
glycol
(PEG)
polypropylene
(PPG)
backbones
with
varying
functionalities
(di‐acrylate
versus
hexa‐acrylate),
namely
UPEG2,
UPEG6,
UPPG2,
UPPG6.
Tubular
constructs
precise
dimensions
morphology
fabricated.
PPG‐based
exhibit
superior
computer‐aided
design/manufacturing
(CAD/CAM)
mimicry
compared
to
PEG‐based
derivatives.
Construct
characterization
reveals
tunable
properties,
elastic
moduli
ranging
45
259
kPa,
reaching
values
human
In
particular,
UPPG6
shows
two‐fold
higher
modulus
UPPG2.
All
materials
show
excellent
biocompatibility.
Additionally,
surface
modification
gelatin‐methacryloyl
(GELMA)
significantly
enhances
cytocompatibility
UPPG2
scaffolds.
This
study
demonstrates
feasibility
using
polymers.
