Biodegradable plastics: mechanisms of degradation and generated bio microplastic impact on soil health
Rishpreet Kaur,
Indu Chauhan
Biodegradation,
Год журнала:
2024,
Номер
35(6), С. 863 - 892
Опубликована: Июль 10, 2024
Язык: Английский
Recent trends on polycaprolactone as sustainable polymer-based drug delivery system in the treatment of cancer: Biomedical applications and nanomedicine
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
666, С. 124734 - 124734
Опубликована: Сен. 28, 2024
Язык: Английский
Selective Laser Sintering PLA/Mg Composite Scaffold with Promoted Degradation and Enhanced Mechanical
Journal of Polymers and the Environment,
Год журнала:
2024,
Номер
32(9), С. 4302 - 4314
Опубликована: Март 25, 2024
Язык: Английский
Recent Advances in Additive Manufacturing of Polycaprolactone-Based Scaffolds for Tissue Engineering Applications: A Comprehensive Review
Regenerative Engineering and Translational Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 18, 2024
Язык: Английский
Collagen-based 3D printed poly (glycerol sebacate) composite scaffold with biomimicking mechanical properties for enhanced cartilage defect repair
Yu-Yao Liu,
C Intini,
Marko Dobricic
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
unknown, С. 135827 - 135827
Опубликована: Сен. 1, 2024
Язык: Английский
Melt-extruded biocompatible surgical sutures loaded with microspheres designed for wound healing
Biomedical Materials,
Год журнала:
2024,
Номер
19(5), С. 055007 - 055007
Опубликована: Июнь 25, 2024
Sutures
are
commonly
used
in
surgical
procedures
and
have
immense
potential
for
direct
drug
delivery
into
the
wound
site.
However,
incorporating
active
pharmaceutical
ingredients
sutures
has
always
been
challenging
as
their
mechanical
strength
deteriorates.
This
study
proposes
a
new
method
to
produce
microspheres-embedded
that
offer
adequate
properties
effective
healing
applications.
The
curcumin,
bioactive
compound
found
turmeric,
model
due
its
anti-inflammatory,
antioxidant,
anti-bacterial
properties,
which
make
it
an
ideal
candidate
suture
system.
Curcumin-loaded
microspheres
were
produced
using
emulsion
solvent
evaporation
with
polyvinyl
alcohol
(PVA)
aqueous
phase.
microspheres'
particle
sizes,
loading
(DL)
capacity,
encapsulation
efficiency
(EE)
investigated.
Microspheres
melt-extruded
polycaprolactone
polyethylene
glycol
via
3D
bioplotter,
followed
by
drawing
process
optimise
strength.
sutures'
thermal,
physiochemical,
investigated,
biocompatibility
evaluated.
results
showed
increasing
phase
concentration
resulted
smaller
sizes
improved
DL
capacity
EE.
if
PVA
was
at
3%
w/v
or
below,
prevented
aggregate
formation
after
lyophilisation,
average
size
be
34.32
±
12.82
μm.
addition
of
had
diameter
0.38
0.02
mm,
smooth
surface,
minimal
tissue
drag,
proper
tensile
Furthermore,
encapsulated
drug-polymer
structure,
exhibited
prolonged
sustained
release
up
14
d.
Microsphere-loaded
demonstrated
non-toxicity
accelerated
Язык: Английский
Antibacterial, antioxidant, and anti‐inflammatory surgical sutures fabricated by melt mixing of a polymer blend with curcumin‐loaded microspheres
Polymer Engineering and Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
Abstract
A
surgical
suture
is
a
critical
medical
device
used
to
close
and
secure
body
tissues
following
surgery,
injury,
or
other
procedures,
but
it
often
associated
with
the
risk
of
site
infections
(SSIs).
To
mitigate
this
risk,
drug‐eluting
sutures
antimicrobial
anti‐inflammatory
properties
have
been
developed.
However,
incorporation
active
pharmaceutical
ingredients
(APIs)
frequently
compromises
mechanical
sutures.
address
these
challenges,
curcumin‐loaded
microspheres
were
first
produced
via
emulsion
solvent
evaporation
method
then
embedded
into
polymeric
carriers
PCL‐PEG
using
melt‐extrusion
technique
achieve
optimal
diameters,
thereby
enhancing
strength
creating
an
innovative
drug‐delivery
system.
Notably,
containing
Cur‐PLA‐PEG‐PCL
demonstrated
highest
tensile
(170.20
±
22.73
MPa)
due
presence
PCL.
Meanwhile,
Cur‐PLA‐PEG
exhibited
high
breaking
stability
during
degradation,
retaining
89.96%
their
initial
by
Day
14.
All
samples
also
antibacterial
activity,
direct
correlation
between
incubation
duration
antioxidant
potential.
These
findings
suggest
that
hold
significant
potential
for
clinical
applications
in
improving
wound
healing
reducing
infections.
Highlights
Curcumin‐loaded
polymer
melt
extrusion.
PLA‐PEG‐PCL
offer
170.20
MPa.
Sutures
retain
14,
showing
degradation.
Sustained
release
curcumin
from
provides
prolonged
therapeutic
effects.
inflammation,
IL‐6
expression
keratinocytes.
Язык: Английский
Smart Films Produced by Electrospinning of Poly(butylene-adipate-co‑terephthalate)/poly-(ε-caprolactone) for Controlled Delivery of Ibuprofen
Journal of the Brazilian Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Wound
dressing
devices
composed
of
microfibers
poly(butylene-adipate-co-terephthalate)
and
poly-(ε-caprolactone)
incorporated
with
ibuprofen
were
obtained
by
electrospinning
technique.
The
effect
concentration
(0,
10,
20%
m
m-1)
on
morphology,
spectroscopic,
thermal
characterization
was
evaluated.
fibers
containing
presented
beads
revealed
no
uniformity.
spectroscopic
analysis
showed
signals
that
reveal
the
incorporation
fibers.
At
same
time,
X-ray
diffraction
spectroscopy
indicated
a
difference
in
fiber
crystallinity
depending
drug
concentration,
where
lower
verified
film
greater
incorporated.
Rheological
measurements
films
more
plastic
incorporation.
Contact
angle
solubilization
composite
surfaces
increased
wettability.
Finally,
promoted
controlled
release
ibuprofen,
promoting
morphological
changes
polymeric
matrices.
material
developed
can
be
used
future
biomedical
applications.
Язык: Английский
Selective laser sintering PLA/Mg composite scaffold with promoted degradation and enhanced mechanical
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 16, 2023
Abstract
The
slow
degradation
rate
of
PLA
is
an
urgent
problem
that
needs
to
be
solved
improve
its
application
in
tissue
engineering.
In
this
study,
different
proportions
Mg
were
introduced
into
promote
and
regulate
degradation.
A
porous
composite
bone
scaffold
was
prepared
using
selective
laser
sintering
(SLS)
technology.
After
the
introduction
Mg,
products
consumed
acidic
by
hydrolysis
PLA,
which
destroyed
integrity
molecular
chain
accelerated
flow
chain,
formed
a
cycle
promoted
results
showed
weight
loss
Mg-added
nearly
seven
times
higher
than
pure
within
four
weeks.
terms
mechanics,
compressive
strength
PLA/3Mg
(5.6
MPa)
twice
(2.67
MPa).
Therefore,
we
believe
appropriate
can
better
balance
between
mechanical
properties
scaffolds.
Язык: Английский