Applications of Diels–Alder Chemistry in Biomaterials and Drug Delivery DOI Creative Commons
Tyus J. Yeingst, Angelica M. Helton, Daniel J. Hayes

и другие.

Macromolecular Bioscience, Год журнала: 2024, Номер unknown

Опубликована: Окт. 26, 2024

Recent studies, leveraging click chemistry reactions, have significantly advanced the fields of biomaterials and drug delivery. Of these Diels-Alder cycloaddition is exceptionally valuable for synthetic organic biomaterial design, as it occurs under mild reaction conditions can undergo a retrograde reaction, physiologically relevant conditions, to yield initial reactants. In this review, potential applications are explored within nexus This includes an emphasis on key platforms such polymers, nanoparticles, hydrogels which utilize delivery, functionalized surfaces, bioconjugation, other diverse applications. Specifically, review will focus use in tissue engineering cancer therapies, while providing discussion advantages, platforms, chemistry.

Язык: Английский

Development and evaluation of novel chromone-functionalized benzo crown ether-based poly (vinyl chloride) nanofibers by electrospinning DOI
Duygu Şahin Gül, Gokhan Acik,

Fatmagul Halici Demir

и другие.

European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113719 - 113719

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1

Dynamic Covalent Bond-Based Polymer Chains Operating Reversibly with Temperature Changes DOI Creative Commons
Sojeong Roh,

Yeonjeong Nam,

My Thi Ngoc Nguyen

и другие.

Molecules, Год журнала: 2024, Номер 29(14), С. 3261 - 3261

Опубликована: Июль 10, 2024

Dynamic bonds can facilitate reversible formation and dissociation of connections in response to external stimuli, endowing materials with shape memory self-healing capabilities. Temperature is an stimulus that be easily controlled through heat. covalent temperature reversibly connect, exchange, convert chains the polymer. In this review, we introduce dynamic operate without catalysts various ranges. The basic bonding mechanism kinetics are examined understand chemistry performed by equilibrium control. Furthermore, a recent synthesis method implements coupling based on polymers introduced. depending applied expand use polymers, providing predictions for development future smart materials.

Язык: Английский

Процитировано

7

Graphene-Oxide Peptide-Containing Materials for Biomedical Applications DOI Open Access

Andreea Gostaviceanu,

Simona Gavrilaș, Lucian Copolovici

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 10174 - 10174

Опубликована: Сен. 22, 2024

This review explores the application of graphene-based materials (GBMs) in biomedicine, focusing on graphene oxide (GO) and its interactions with peptides proteins. GO, a versatile nanomaterial oxygen-containing functional groups, holds significant potential for biomedical applications but faces challenges related to toxicity environmental impact. Peptides proteins can be functionalized GO surfaces through various methods, including non-covalent such as π–π stacking, electrostatic forces, hydrophobic interactions, hydrogen bonding, van der Waals well covalent bonding reactions involving amide bond formation, esterification, thiol chemistry, click chemistry. These approaches enhance GO’s functionality several key areas: biosensing sensitive biomarker detection, theranostic imaging that integrates diagnostics therapy real-time treatment monitoring, targeted cancer where deliver drugs directly tumor sites while being tracked by techniques like MRI photoacoustic imaging. Additionally, GO-based scaffolds are advancing tissue engineering aiding tissues’ bone, muscle, nerve regeneration, their antimicrobial properties improving infection-resistant medical devices. Despite potential, addressing stability scalability is essential fully harness benefits GBMs healthcare.

Язык: Английский

Процитировано

4

Tunable Chemotherapy Release Using Biocompatible Fatty Acid-Modified Ethyl Cellulose Nanofibers DOI Creative Commons

Michael Wildy,

Qiangjun Hao,

Wanying Wei

и другие.

Carbohydrate Polymer Technologies and Applications, Год журнала: 2025, Номер unknown, С. 100670 - 100670

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

‘Clickable’ polymer brush coated magnetic nanoparticles: Employing Diels-Alder and azide-alkyne cycloaddition for modular targeted drug delivery platforms DOI
Busra Cengiz, Aysun Degirmenci,

Nora Ejderyan

и другие.

European Polymer Journal, Год журнала: 2024, Номер 220, С. 113490 - 113490

Опубликована: Окт. 5, 2024

Язык: Английский

Процитировано

3

Acupoint catgut from electrospun tri-layer core–shell fibers loaded with adenosine for a long-term analgesia effect DOI
Wanrong Li,

Xuan Zhang,

Ying Chen

и другие.

European Polymer Journal, Год журнала: 2024, Номер 220, С. 113447 - 113447

Опубликована: Сен. 6, 2024

Язык: Английский

Процитировано

2

Diels–Alder Cycloaddition of 2,5-Bis(hydroxymethyl)furan (BHMF) and N-Phenylmaleimide Derivatives DOI Creative Commons
Harshit Shukla,

Peerapong Promcharoen,

Thinnaphat Poonsawat

и другие.

ACS Omega, Год журнала: 2024, Номер unknown

Опубликована: Авг. 14, 2024

Currently, amidst atmospheric menace where natural calamities such as wildfire and floods are becoming more frequent than ever, biobased derivatives offer a sustainable alternative to conventional ways, for instance, petrochemical commodities. Biobased products, obtained from agricultural waste, including 5-(hydroxymethyl)furfural (HMF), 2,5-bis(hydroxymethyl)furan (BHMF), 2,5-furandicarboxylic acid (FDCA) promising chemical platforms in the biorefinery, which is yet be explored. The Diels–Alder cycloaddition of BHMF N-phenylmaleimide under optimal reaction conditions investigated this report. First, HMF reduced presence NaBH4, then produce adducts. All novel compounds synthesized acceptable yields effectively characterized by employing important techniques one-dimensional (1D) NMR spectroscopy (1H, 13C, DEPT-90, DEPT- 135), two-dimensional (2D) (1H–1H COSY, 1H–13C HSQC, HMBC), IR spectroscopy, elemental analysis, mass spectrum (QTOF), single-crystal X-ray diffraction (SC-XRD). Furthermore, study underlines necessity synthetic methodologies gives critical insights into progress ecologically friendly methodologies, providing new avenue tunable precursor challenging functionalized polymer future.

Язык: Английский

Процитировано

1

Applications of Diels–Alder Chemistry in Biomaterials and Drug Delivery DOI Creative Commons
Tyus J. Yeingst, Angelica M. Helton, Daniel J. Hayes

и другие.

Macromolecular Bioscience, Год журнала: 2024, Номер unknown

Опубликована: Окт. 26, 2024

Recent studies, leveraging click chemistry reactions, have significantly advanced the fields of biomaterials and drug delivery. Of these Diels-Alder cycloaddition is exceptionally valuable for synthetic organic biomaterial design, as it occurs under mild reaction conditions can undergo a retrograde reaction, physiologically relevant conditions, to yield initial reactants. In this review, potential applications are explored within nexus This includes an emphasis on key platforms such polymers, nanoparticles, hydrogels which utilize delivery, functionalized surfaces, bioconjugation, other diverse applications. Specifically, review will focus use in tissue engineering cancer therapies, while providing discussion advantages, platforms, chemistry.

Язык: Английский

Процитировано

1