Polymeric nanoparticles as delivery vehicles for targeted delivery of chemotherapy drug fludarabine to treat hematological cancers
Inorganic Chemistry Communications,
Год журнала:
2024,
Номер
167, С. 112819 - 112819
Опубликована: Июль 6, 2024
Язык: Английский
Advancing cancer therapy: Unveiling the cutting-edge potential of carmustine nano carriers for targeted treatment
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
99, С. 105943 - 105943
Опубликована: Июль 4, 2024
Язык: Английский
Understanding the journey of biopolymeric nanoformulations for oral drug delivery: Conventional to advanced treatment approaches
European Polymer Journal,
Год журнала:
2024,
Номер
218, С. 113338 - 113338
Опубликована: Июль 26, 2024
Язык: Английский
Advancements in Nanocarrier-Mediated Sunitinib Delivery: Addressing Obstacles and Revealing its Therapeutic Promise in Oncological Treatment
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
100, С. 106107 - 106107
Опубликована: Авг. 25, 2024
Язык: Английский
Advances in polymeric and non-polymeric nanocarriers for the magnified delivery of levofloxacin against bacterial infection
Journal of Nanoparticle Research,
Год журнала:
2024,
Номер
26(8)
Опубликована: Авг. 1, 2024
Abstract
This
review
examines
the
latest
developments
in
nanoscopic
antibiotic
formulations
used
to
treat
infections
caused
by
bacteria.
A
wide
range
of
nanocarrier
platforms
are
discussed,
including
polymer-based
nanoparticles
(NPs),
lipid-based
vesicles,
mesoporous
silica,
and
other
inorganic
materials.
The
levofloxacin
(LVF)
is
predominantly
as
a
model
drug
given
its
broad-spectrum
activity.
Studies
this
regard
have
evaluated
loading
encapsulation
efficiency
(EE)
using
analytical
techniques
such
FTIR,
DLS,
TEM.
In
vitro
release
kinetics
was
characterized
through
dialysis
fluorescence-based
assays.
Zone
inhibition
viability
studies
provided
insights
into
antibacterial
efficacy.
Some
approaches
incorporated
stimuli-responsive
polymers
or
targeting
ligands
facilitate
controlled
targeted
release.
Overall,
nanocarriers
demonstrated
potential
for
sustained
levels,
reduced
dosing,
improved
treatment
biofilms
intracellular
compared
free
administration.
offers
comprehensive
analysis
promising
field
with
implications
combating
resistance.
Язык: Английский
Revolutionizing Cancer Treatment: Exploring the Latest Breakthroughs in Bicalutamide Delivery and Co-Delivery Nanoformulations for Cancer Therapy
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
unknown, С. 106201 - 106201
Опубликована: Сен. 1, 2024
Язык: Английский
Formulation of Felodipine lipid nanoparticle-loaded oral fast-dissolving films
Suparna Anand Naik,
Cleona Elizabeth Mary DCruz,
Lalit Kumar
и другие.
Tenside Surfactants Detergents,
Год журнала:
2024,
Номер
61(6), С. 568 - 583
Опубликована: Окт. 8, 2024
Abstract
Felodipine,
a
calcium
channel
blocker
used
to
treat
hypertension,
is
BCS
Class
II
drug
characterized
by
low
solubility,
high
permeability
and
significant
hepatic
metabolism,
which
limits
its
bioavailability
15
%.
This
study
focuses
on
improving
the
of
Felodipine
developing
oral
fast-dissolving
films
(OFDFs)
incorporating
lipid
nanoparticles.
loaded
nanoparticles
were
prepared
using
glyceryl
monooleate
(GMO)
as
Poloxamer
407
surfactant,
then
incorporated
into
OFDFs
solvent
casting
technique.
A
Box-Behnken
design
with
Design
Expert
Stat-Ease
®
360
was
evaluate
impact
GMO,
concentration,
sonication
time
particle
size
entrapment
efficiency.
The
resulting
nanoparticle
dispersions
had
sizes
ranging
from
74.92
nm
112.1
efficiencies
between
80.43
%
95.23
Differential
scanning
calorimetry
(DSC),
Fourier
transform
infrared
spectroscopy
(FTIR),
X-ray
diffraction
(XRD)
confirmed
successful
encapsulation.
OFDF
showed
optimal
mechanical
properties,
disintegration
within
(41.33
±
3.51)
s,
an
in-vitro
release
(89.82
2.75)
in
6
min.
Scanning
electron
microscopy
(SEM)
revealed
smooth,
uniform,
porous
surface
remained
stable
for
three
months.
concludes
that
improve
permeability,
dissolution,
onset
action,
making
them
promising
approach
antihypertensive
therapy.
Язык: Английский