Materials Advances, Год журнала: 2024, Номер 5(21), С. 8524 - 8533
Опубликована: Янв. 1, 2024
Planktonic bacteria can be eliminated by gold nanoparticles photothermia.
Язык: Английский
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114688 - 114688
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 310, С. 143440 - 143440
Опубликована: Апрель 23, 2025
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 24, 2025
The advancement in exclusively tailored therapeutic delivery systems has escalated a great deal of interest targeted to augment efficacy and lessen adverse effects. approach promisingly helps surmount the unmet clinical needs conventional therapies, including chemoresistance, limited penetration, side In case melanoma, various receptors were overexpressed on tumor site, among which folate receptor (FR) targeting is considered be progressive for managing melanoma. FRs are macromolecules glycosyl phosphatidylinositol-attached protein that possess globular assembly with greater affinity toward specific ligands. So, functional ligands can utilized design nanocarriers (NCs) effectively bind FRs. Hence, folate-adorned NCs (FNCs) offer benefits such as site-specific targeting, cargo protection, minimizing toxicity. This review focuses insights implications FRs, mechanisms, challenges, advantages FNCs. Further, applications FNCs, liposomes, polymeric NCs, albumin nanoparticles, inorganic liquid crystalline nanogels, have been elaborated melanoma therapy. Likewise, potential FNCs immunotherapy, photodynamic therapy, chemotherapy, gene photothermal imaging exhaustively discussed. Furthermore, translational hurdles solutions discussed detail. present expected give thoughtful ideas researchers, industry stakeholders, formulation scientists efficacious development
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Июнь 2, 2025
The near-infrared second window (NIR-II) offers excellent spatial resolution and tissue penetration, drawing attention to NIR-II laser-excited photothermal therapy (PTT) fluorescence imaging. However, integrating these two applications poses challenges due safe laser power reagent dosage constraints. To overcome issues, we proposed modifying the ternary copolymer backbone by substituting 4H-cyclopenta[2,1-b:3,4-b']dithiophene (DTC) with 4,9-dihydro-s-indaceno[1,2-b:5,6-b']dithiophene (IDT), enabling a transition from agent. Adjusting molar ratios of donor acceptor units coupling either DTC or IDT in polymer significantly affects their photophysical properties. Among synthesized copolymers, PDTC-253 showed optimal performance, while PIDT-253 exhibited high quantum yields. Both were used create biocompatible nanoparticles (NPs). Under 1064 nm irradiation, NPs effectively eliminated 4T1 cancer cells vitro. In vivo studies mice bearing tumors that could accumulate at tumor sites, facilitating treatment varying sizes under provided long-term tracking through imaging, clearly visualizing blood vessels even wavelengths reaching 1500 nm. This approach advances development effective phototheranostic agents for PTT imaging window.
Язык: Английский
Процитировано
0
European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2024, Номер 204, С. 114485 - 114485
Опубликована: Сен. 8, 2024
Язык: Английский
Процитировано
1
Materials Advances, Год журнала: 2024, Номер 5(21), С. 8524 - 8533
Опубликована: Янв. 1, 2024
Planktonic bacteria can be eliminated by gold nanoparticles photothermia.
Язык: Английский
Процитировано
0