Self-Healing Hydrogels with Intrinsic Antioxidant and Antibacterial Properties Based on Oxidized Hydroxybutanoyl Glycan and Quaternized Carboxymethyl Chitosan for pH-Responsive Drug Delivery

Gels, Год журнала: 2025, Номер 11(3), С. 169 - 169

Опубликована: Фев. 26, 2025

In this study, self-healing hydrogels were created using oxidized hydroxybutanoyl glycan (OHbG) and quaternized carboxymethyl chitosan (QCMCS), displaying antioxidant antibacterial properties for pH-responsive drug delivery. The structures of the modified polysaccharides confirmed through 1H NMR analysis. Double crosslinking in hydrogel occurred via imine bonds (between aldehyde group OHbG amine QCMCS) ionic interactions carboxyl QCMCS). exhibited improved thermal stability with an increase concentration. OHbG/QCMCS demonstrated high compressive strength, significant swelling, large pore size. Drug release profiles varied between pH 2.0 (96.57%) 7.4 (63.22%). Additionally, displayed effects without compromising polysaccharides’ inherent characteristics. No cytotoxicity was observed any samples. These findings indicate that is a biocompatible stimuli-responsive carrier, potential various pharmaceutical, biomedical, biotechnological applications.

Язык: Английский

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Injectable sodium alginate/4-arm polyethylene glycol-lipoic acid double-network hydrogel loading Ca2+-tannic acid nanocomposite treats periodontitis via anti-bacteria, ROS scavenging and osteogenesis

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 307, С. 141841 - 141841

Опубликована: Март 8, 2025

Язык: Английский

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Plant Polyphenol‐Based Injectable Hydrogels: Advances and Biomedical Applications

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Plant polyphenol-based hydrogels, known for their biocompatibility and adhesive properties, have emerged as promising materials in biomedical applications. These hydrogels leverage the catechol group's ability to form stable bonds moist environments, similar mussel proteins. This review provides a comprehensive overview of synthesis, adhesion mechanisms, applications, particularly wound healing, tissue regeneration, drug delivery. However, challenges related vivo stability long-term remain critical barriers clinical translation. Future research should focus on enhancing bioactivity, biocompatibility, scalability these while addressing concerns toxicity, immune responses, large-scale manufacturing. Advances artificial intelligence-assisted screening 3D/4D bioprinting are expected accelerate development Furthermore, integration biomimetic designs responsive functionalities, such pH or temperature sensitivity, holds promise further improving therapeutic efficacy. In conclusion, multifunctional plant represents frontier advancing personalized medicine minimally invasive treatments.

Язык: Английский

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A photothermal antimicrobial, antioxidant hydrogel for healing of bacterial-infected wounds

Polymer, Год журнала: 2025, Номер unknown, С. 128332 - 128332

Опубликована: Март 1, 2025

Язык: Английский

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Dopamine-conjugated Hyaluronic Acid Hydrogel Interpenetrated by Genipin Crosslinked Quaternary Ammonium Chitosan for Potential Biomedical Adhesives Applications

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114683 - 114683

Опубликована: Апрель 1, 2025

Язык: Английский

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Self-healing, Adhesive, Antibacterial, and Biocompatible Hydrogel Dressings using Sialic Acid Substituted Chitosan and Oxidized Pullulan with Incorporation of Epigallocatechin gallate

Composites Communications, Год журнала: 2024, Номер unknown, С. 102107 - 102107

Опубликована: Сен. 1, 2024

Язык: Английский

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