Advances in Mesoporous Silica Nanoparticles as Carriers for Drug Delivery and other Biomedical Applications
Microporous and Mesoporous Materials,
Год журнала:
2025,
Номер
unknown, С. 113603 - 113603
Опубликована: Март 1, 2025
Язык: Английский
Longan-inspired chitosan-pectin core-shell hydrogel beads for oral delivery of biodrugs to enhance osteoporosis therapy
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142254 - 142254
Опубликована: Март 1, 2025
Osteoporosis,
a
common
disorder,
is
characterized
by
systemic
reduction
in
bone
mass
and
structural
integrity,
resulting
brittle
bones.
Reducing
loss
enhancing
density
through
oral
administration
of
biopharmaceuticals
provides
significant
advantages,
including
convenience
non-invasiveness
for
patients.
However,
challenges
such
as
poor
absorption
enzymatic
degradation
necessitate
the
development
innovative
drug
delivery
systems.
This
research
introduces
core-shell
hydrogel
system
inspired
natural
architecture
Longan
fruit,
constructed
from
pectin
chitosan
biopolymers,
designed
to
create
biocapsules
sustain
release
biodrugs.
In
this
system,
salmon
calcitonin
(sCT)
was
encapsulated
within
mesoporous
silica
nanoparticles
(MSNs)
incorporated
into
core
beads.
The
synthesis
beads
carefully
regulated
adjusting
immersion
time
concentration
crosslinker.
demonstrated
durability,
with
shell
effectively
preventing
rapid
stomach,
while
layer
enhanced
adhesion
intestinal
walls,
safeguarded
sCT,
enabled
sustained
over
an
extended
period
up
30
h.
Furthermore,
biocompatibility
tests
indicated
minimal
cytotoxicity
hemolysis.
Cellular
uptake
assays
that
sCT
ensured
its
prolonged
CT-26
cells.
study
presents
promising
platform
delivery,
offering
efficacy,
patient
compliance,
potential
replacement
injection-based
therapies.
Язык: Английский
Mineralized Biopolymers‐Based Scaffold Encapsulating with Dual Drugs for Alveolar Ridge Preservation
Macromolecular Bioscience,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 15, 2024
Abstract
Mineralization
of
scaffolds
is
essential
for
alveolar
ridge
preservation
and
bone
tissue
engineering,
enhancing
the
mechanical
strength
bioactivity
scaffolds,
promoting
better
integration
with
natural
tissue.
While
in
situ
mineralization
method
using
concentrated
SBF
solutions
promising,
there
limited
comprehensive
research
on
its
effects.
In
this
study,
it
demonstrate
that
soaking
gelatin/alginate
(GAS)
fivefold
significantly
reduces
time
to
3–7
days
but
also
leads
considerable
degradation
loss
scaffold's
original
microstructure.
The
ratio
gelatin
alginate
optimized
improve
properties
GAS.
GAS
sample,
when
soaked
form
GAS/HAp,
exhibited
hydroxyapatite
(HAp)
crystal
formation
starting
from
day
3,
mature
hexagonal
crystals
forming
by
7.
However,
process
caused
significant
decomposition
deformation
pore
structure.
Additionally,
biocompatibility
GAS/HAp
evaluated
through
vitro,
ovo,
haemolysis,
anti‐ROS
assays.
findings
highlight
impact
5×
GAS,
laying
groundwork
further
engineering.
Язык: Английский
pH- and redox-sensitive selenium-incorporated mesoporous silica nanoparticles for osteosarcoma-targeted treatment
Materials & Design,
Год журнала:
2025,
Номер
unknown, С. 113883 - 113883
Опубликована: Март 1, 2025
Язык: Английский
Biocompatible Materials for Light Emitters
Engineering materials,
Год журнала:
2025,
Номер
unknown, С. 65 - 72
Опубликована: Янв. 1, 2025
Язык: Английский
Dual-functional injectable hydrogel as antimicrobial and angiogenic therapeutics for dental pulp regeneration
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Development
of
an
injectable
polysaccharide-based
hydrogel
system
with
antibacterial
and
angiogenic
properties
for
pulpitis
treatment.
Язык: Английский
Development and Characterization of Folic Acid‐Decorated Fucoidan‐Poloxamer 407 Self‐Assembled Nanogels Co‐Loading Curcumin and Paclitaxel for Synergistically Enhanced Chemotherapeutic Efficacy
Journal of Polymer Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 5, 2025
ABSTRACT
Cancer‐targeted
nanomedicines
demonstrate
considerable
potential
in
anticancer
treatment
due
to
their
unique
properties
that
improve
therapeutic
efficiency
while
minimizing
off‐target
effects.
In
this
research,
curcumin
(Cur)
and
paclitaxel
(PTX)
were
co‐loaded
into
dual‐targeting
folate
receptor/P‐selectin
nanocarriers,
which
based
on
folate‐conjugated
fucoidan‐poloxamer
407
copolymers
(FA‐FP407),
aiming
inhibit
breast
cancer
through
intravenous
administration.
The
successful
synthesis
of
the
self‐assembled
nanogels
was
confirmed
by
analyzing
chemical
composition.
resulting
exhibited
optimal
physicochemical
properties,
including
a
negative
surface
charge,
spherical
morphology,
hydrodynamic
diameter
158.27
±
3.15
nm,
along
with
high
drug‐loading
efficiency.
vitro
drug
release
from
significantly
accelerated
within
tumor
microenvironment
at
pH
5.5,
it
slowed
down
under
physiological
conditions.
kinetics
adhered
Fickian
diffusion
model.
Additionally,
blank
nanocarriers
both
hemocompatible
cytocompatible,
although
they
slight
growth
inhibition
MCF‐7
cells.
FA‐FP407@Cur@PTX
demonstrated
lower
IC
50
compared
free
formulations
single
drug‐loaded
cells,
indicating
could
enhance
activity
co‐administering
different
drugs
precisely
accumulating
cancerous
site.
This
effect
is
attributed
strong
synergistic
actions
receptor‐mediated
cellular
uptake.
study
provides
solid
foundation
for
advancing
targeted
nanomedicine,
facilitating
co‐delivery
multiple
agents
achieve
superior
effects
chemotherapy.
Язык: Английский
Cholesterol‐Conjugated PAMAM Dendrimers: Enhancing Stability, Drug Delivery Efficiency, and In Vitro Anticancer Performance
Journal of Polymer Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 24, 2024
ABSTRACT
Nanomaterials
offer
great
potential
in
cancer
treatment,
particularly
drug
delivery,
where
their
unique
properties
allow
for
targeted
therapy,
increasing
treatment
efficacy
while
minimizing
side
effects.
Dendrimers,
with
highly
branched
structure,
are
ideal
candidates
delivery.
However,
polyamidoamine
(PAMAM)
dendrimers,
despite
versatility,
exhibit
cytotoxicity.
Modifying
PAMAM
dendrimers
cholesterol
through
p‐nitrophenyl
chloroformate
(NPC)
mediation
enhances
biocompatibility
and
targeting
ability,
especially
toward
cells.
In
this
study,
G3.0
was
successfully
synthesized
conjugated
to
form
G3C
nanogels,
a
nanoscale
size
of
83.8
±
21.9
nm.
The
study
conjugation
revealed
that
at
25%
surface
functionalization
G3.0,
exhibited
stable
behavior
PBS
buffer
up
8
days.
system's
capacity
load
single
or
dual
drugs
also
explored,
demonstrating
controlled
release
over
96
h.
Moreover,
modification
on
significantly
enhanced
cell
compatibility.
G3C@QU/PTX
system
improved
HeLa
cells
vitro
compared
healthy
fibroblast
This
research
provides
strong
foundation
developing
nanomaterials
treatment.
Язык: Английский