Preparation, Characterization, and Drug Release of Electrospun Core‐Shell Structured Hyaluronic Acid‐Bovine Serum Albumin/Poly(ε‐Caprolactone) Nanofiber Membranes

Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

ABSTRACT Albumin has broad applications in tissue engineering, yet challenges remain maintaining activity, loading capacity, and controlled release. In this study, we employed electrospinning to fabricate protein‐polysaccharide/poly(ε‐caprolactone) (PCL) nanofibers with a core‐shell structure. High‐magnification projection microscopy characterized the spinnability of hyaluronic acid‐bovine serum albumin (HyA‐BSA) solution. Scanning electron high‐magnification demonstrated that had uniform diameter internal structure, Fourier‐transform infrared spectroscopy confirming successful encapsulation HyA‐BSA within PCL fibers. X‐ray diffraction indicated crystallite size decreased increasing Span80 content. Tensile water contact angle tests revealed improvements flexibility wettability nanofibers. vitro drug BSA release rate could be modulated by varying concentrations, total time exceeding 30 days. Overall, research enables prolonged offers new insights for protein encapsulation.

Язык: Английский

Development and evaluation of nilotinib-loaded Bovine Serum Albumin nanoparticles: In-vitro and in-silico insights

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142185 - 142185

Опубликована: Март 1, 2025

Язык: Английский

Research progress and prospect of tumor nanovaccine combination therapy strategy

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110771 - 110771

Опубликована: Дек. 1, 2024

Язык: Английский