TRIM65 regulates glucose metabolic reprogramming to promote glioma cell proliferation via ubiquitination and degradation of AMPK DOI Creative Commons
Minghui Li, Tao Wang, Xiao‐Hui Guan

и другие.

npj Precision Oncology, Год журнала: 2025, Номер 9(1)

Опубликована: Июнь 5, 2025

Glioma is the most common primary malignant brain tumor with high mortality and poor prognosis. Aerobic glycolysis crucial for behavior of glioma by promoting their growth. Tripartite motif containing 65 (TRIM65) as an E3 ubiquitin ligase has been implicated in progression, but its role regulatory mechanism on aerobic remains unclear. Here, it was demonstrated that TRIM65 highly expressed human tissues associated Moreover, knockdown inhibited cells proliferation vitro vivo. RNA sequencing biological verifications were performed to elucidate a novel underlying silencing attenuated enhanced OXPHOX suppress growth cells. Subsequently, we found interacted AMPK, metabolic sensor, mediated K48-linkage ubiquitination degradation though proteasomal pathway, thereby regulating HIF-1α-induced glycolysis. Importantly, inhibitory effect abrogated AMPK or HIF-1α overexpression, indicating glucose reprogramming dependent pathway. These results reveal new TRIM65/AMPK/HIF-1α axis cell glycolysis, suggesting may be potential therapeutic target intervention glioma.

Язык: Английский

Exosome’s Implications in Age-Related Macular Degeneration DOI
Ali Torkashvand, Amir Reza Hajrasouliha

Current Eye Research, Год журнала: 2025, Номер unknown, С. 1 - 8

Опубликована: Янв. 24, 2025

Purpose This study aims to conduct a mini review of published literature concerning the role exosomes in field ophthalmology, with specific focus on Age-Related Macular Degeneration (AMD).

Язык: Английский

Процитировано

0
Exosomes in treating Eye Diseases: Targeting strategies DOI

Pengfei Ge,

Jingfan Wang, Ping Xie

и другие.

Life Sciences, Год журнала: 2025, Номер unknown, С. 123598 - 123598

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Exosome Innovations in Ophthalmology and Sjögren’s Syndrome DOI
Kevin Y. Wu,

Archan Dave,

Gurleen K. Nirwal

и другие.

Advances in experimental medicine and biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Extracellular vesicles in age-related diseases: disease pathogenesis, intervention, and biomarker DOI Creative Commons

Puan Haliza Lintang Putri,

Samira Husen Alamudi, Xuan Dong

и другие.

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Май 28, 2025

Aging is a multifactorial biological process characterized by the irreversible accumulation of molecular damage, leading to an increased risk age-related diseases. With global prominent rise in aging populations, elucidating mechanisms underlying and developing strategies combat diseases have become pressing priority. Extracellular vesicles (EVs) gained significant attention due their role intercellular communication. EVs are known for ability deliver biocargoes, such as miRNA, proteins, lipids, implicating involvement disease pathogenesis intervention. In this review article, we explore dual diseases: contributing transferring deleterious molecules, while also offering therapeutic beneficial molecules. We highlight application biomarkers early diagnosis diseases, paving way intervention precision medicine. Additionally, discuss how analysing composition cargo can provide insights into progression. Finally, address challenges future perspectives EV-based-therapy clinical translation, including standardization isolation methods improving specificity.

Язык: Английский

Процитировано

0
Nanotherapeutics for ocular posterior segment diseases therapy: Towards its advances and challenges DOI
Mengdie Li, Shundong Cai, Hongjin Li

и другие.

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111392 - 111392

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
TRIM65 regulates glucose metabolic reprogramming to promote glioma cell proliferation via ubiquitination and degradation of AMPK DOI Creative Commons
Minghui Li, Tao Wang, Xiao‐Hui Guan

и другие.

npj Precision Oncology, Год журнала: 2025, Номер 9(1)

Опубликована: Июнь 5, 2025

Glioma is the most common primary malignant brain tumor with high mortality and poor prognosis. Aerobic glycolysis crucial for behavior of glioma by promoting their growth. Tripartite motif containing 65 (TRIM65) as an E3 ubiquitin ligase has been implicated in progression, but its role regulatory mechanism on aerobic remains unclear. Here, it was demonstrated that TRIM65 highly expressed human tissues associated Moreover, knockdown inhibited cells proliferation vitro vivo. RNA sequencing biological verifications were performed to elucidate a novel underlying silencing attenuated enhanced OXPHOX suppress growth cells. Subsequently, we found interacted AMPK, metabolic sensor, mediated K48-linkage ubiquitination degradation though proteasomal pathway, thereby regulating HIF-1α-induced glycolysis. Importantly, inhibitory effect abrogated AMPK or HIF-1α overexpression, indicating glucose reprogramming dependent pathway. These results reveal new TRIM65/AMPK/HIF-1α axis cell glycolysis, suggesting may be potential therapeutic target intervention glioma.

Язык: Английский

Процитировано

0