Alterations of Monoaminergic Systems in Alzheimer's Disease: A Traditional Review DOI Open Access
Raviye Özen Koca,

Z. Işık SOLAK GÖRMÜŞ,

Hatice Solak

и другие.

Turkiye Klinikleri Journal of Medical Sciences, Год журнала: 2022, Номер 42(4), С. 323 - 334

Опубликована: Янв. 1, 2022

Alzheimer hastalığı (AH); karakteristik klinik ve patolojik özelliklere sahip, yaşla ilişkili, nörodejeneratif bir hastalıktır. AH'den kaynaklanan ölüm oranı, 2020 yılında koronavirüs 2019 pandemisi ile daha da şiddetlenmiştir. En çok bilinen nöropatolojik bulgular; ekstranöronal senil plaklar intranöronal nörofibriler yumaklardır. AH, monoaminerjik sistemleri de içeren birçok nöronal yapıyı etkileyen multisistemik AH fizyopatolojisi nörotransmitterlerde meydana gelen fonksiyonel değişiklikler yakından ilişkilidir. Nöronal sinapsların kaybı nöron ölümü sonucunda asetilkolin gibi nörotransmitterin azaldığı bilinmektedir. AH'de sistemde temel olarak, dopaminerjik innervasyonu sağlayan substansia nigra çekirdeği, serotonerjik dorsal rafe çekirdeği noradrenerjik lokus seruleus histaminerjik tüberomamiller çekirdek önemli dejenerasyona maruz kalmaktadır. Bu çekirdeklerden projeksiyon alan bölgelerde ilgili nörotransmitterlerin düzeylerinde olmaktadır. Kombine tedavi (bilişsel geliştirici tedaviler, nöropsikiyatrik semptomları eden ilaçlar, modifiye edici tedaviler) hastalarında davranışsal anormallikleri azaltmak kognitif fonksiyonları etkili şekilde restore etmek için önemlidir. oluşturulacak stratejileri, sistemin arkasındaki moleküler mekanizmayı anlamayı gerektirmektedir. geleneksel derleme özellikle dopamin, noradrenalin, serotonin histamin mekanizmalarında değişiklikleri ayrıntılı tartışıp, bu konuda bakış açısı sunmayı hedefliyoruz. Sonuç olarak sinyalizasyon mekanizmasının reseptörlerin etkilerinin iyi anlaşılması insanlarda hayvan modellerinde çalışma yapılması gerekmektedir. Böylece, yeni stratejilerinin gelişimi hızlanacaktır.

Highly selective and sensitive fluorescent biosensor for the detection of serotonin and its metabolite by Eu3+-Doped Metal-Organic framework DOI
Yufei Zhong, Guang-Ming Bao,

Mei Qiu

и другие.

Chemical Engineering Journal, Год журнала: 2022, Номер 442, С. 136272 - 136272

Опубликована: Апрель 9, 2022

Язык: Английский

Процитировано

48
Electrochemical Immunosensors Developed for Amyloid-Beta and Tau Proteins, Leading Biomarkers of Alzheimer’s Disease DOI Creative Commons
Abhinav Sharma, Lúcio Angnes, N. Sattarahmady

и другие.

Biosensors, Год журнала: 2023, Номер 13(7), С. 742 - 742

Опубликована: Июль 17, 2023

Alzheimer's disease (AD) is the most common neurological and a serious cause of dementia, which constitutes threat to human health. The clinical evidence has found that extracellular amyloid-beta peptides (Aβ), phosphorylated tau (p-tau), intracellular proteins, are derived from amyloid precursor protein (APP), leading biomarkers for accurate early diagnosis AD due their central role in pathology, correlation with progression, diagnostic value, implications therapeutic interventions. Their detection monitoring contribute significantly understanding advancing care. Available techniques, including magnetic resonance imaging (MRI) positron emission tomography (PET), mainly used validate diagnosis. However, these methods expensive, yield results difficult interpret, have side effects such as headaches, nausea, vomiting. Therefore, researchers focused on developing cost-effective, portable, point-of-care alternative devices detect specific cerebrospinal fluid (CSF) other biofluids. In this review, we summarized recent progress electrochemical immunosensors detecting (Aβ p-tau protein) subtypes (AβO, Aβ(1-40), Aβ(1-42), t-tau, cleaved-tau (c-tau), p-tau181, p-tau231, p-tau381, p-tau441). We also evaluated key characteristics performance developed immunosensing platforms, signal interfaces, nanomaterials or amplifiers, biofunctionalization methods, even primary sensing performances (i.e., sensitivity, linear range, limit (LOD), application).

Язык: Английский

Процитировано

23
Integrated spatial metabolomics and network pharmacology to explore the pharmacodynamic substances and mechanism of Radix ginseng-Schisandra chinensis Herb Couple on Alzheimer’s disease DOI

Yuting Fan,

Aimin Wang,

Zhiqiang Liu

и другие.

Analytical and Bioanalytical Chemistry, Год журнала: 2024, Номер 416(19), С. 4275 - 4288

Опубликована: Июнь 10, 2024

Язык: Английский

Процитировано

8
Monoamine alterations in Alzheimer’s disease and their implications in comorbid neuropsychiatric symptoms DOI Creative Commons
Shalini Saggu,

Ava Bai,

Mae Aida

и другие.

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Сен. 27, 2024

Язык: Английский

Процитировано

8
Cognitive Impairment in Alzheimer’s and Metabolic Diseases: A Catecholaminergic Hypothesis DOI
Kioko Guzmán‐Ramos, Daniel Osorio‐Gómez, Federico Bermúdez‐Rattoni

и другие.

Neuroscience, Год журнала: 2022, Номер 497, С. 308 - 323

Опубликована: Май 30, 2022

Язык: Английский

Процитировано

11
Carving the senescent phenotype by the chemical reactivity of catecholamines: An integrative review DOI

Aleksei G. Golubev

Ageing Research Reviews, Год журнала: 2022, Номер 75, С. 101570 - 101570

Опубликована: Янв. 18, 2022

Язык: Английский

Процитировано

8
Neurochemical mechanisms of perfluoroalkyl substances (PFAS) neurotoxic action DOI
Josephine M. Brown-Leung, Jason R. Cannon

Advances in neurotoxicology, Год журнала: 2023, Номер unknown, С. 367 - 398

Опубликована: Янв. 1, 2023

Язык: Английский

Процитировано

4
Investigating metabolic dysregulation in serum of triple transgenic Alzheimer’s disease male mice: implications for pathogenesis and potential biomarkers DOI Creative Commons
Hongbin Zhuang, Xueshan Cao, Xiaoxiao Tang

и другие.

Amino Acids, Год журнала: 2024, Номер 56(1)

Опубликована: Фев. 5, 2024

Abstract Alzheimer’s disease (AD) is a multifactorial neurodegenerative that lacks convenient and accessible peripheral blood diagnostic markers effective drugs. Metabolic dysfunction one of AD risk factors, which leaded to alterations various metabolites in the body. Pathological changes brain can be reflected are expected explain mechanisms or candidate biomarkers. The aim this study was investigate targeted within mouse model, with purpose exploring mechanism potential Targeted metabolomics used quantify 256 serum triple transgenic (3 × Tg-AD) male mice. Compared controls, 49 differential represented dysregulation purine, pyrimidine, tryptophan, cysteine methionine glycerophospholipid metabolism. Among them, adenosine, serotonin, N-acetyl-5-hydroxytryptamine, acetylcholine play key role regulating neural transmitter network. alteration S-adenosine- l -homocysteine, -methionine, trimethylamine-N-oxide mice served as indicator risk. results revealed serum, suggesting metabolic periphery may related disturbances neuroinhibition, serotonergic system, sleep function, cholinergic gut microbiota. This provides novel insights into several pathways AD, presenting avenues for future research development

Язык: Английский

Процитировано

1
Genetically predicted circulating levels of glycine, glutamate, and serotonin in relation to the risks of three major neurodegenerative diseases: A Mendelian randomization analysis DOI Creative Commons
Ruizhuo Li,

Mengjuan Deng,

Yuhong Lin

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2022, Номер 14

Опубликована: Сен. 7, 2022

It has been previously postulated that blood neurotransmitters might affect risks of neurodegenerative diseases. Here, a Mendelian Randomization (MR) study was conducted to explore whether genetically predicted concentrations glycine, glutamate and serotonin were associated with Alzheimer's disease (AD), Parkinson's (PD), amyotrophic lateral sclerosis (ALS). From three genome-wide association studies European ancestry, single nucleotide polymorphisms strongly selected as genetic instrumental variables. Corresponding summary statistics also obtained from the latest meta-analyses AD, PD ALS. The inverse-variance weighted MR multiple sensitivity analyses performed evaluate causal effects levels on statistical significance threshold set at P < 0.0056 using Bonferroni-correction, while 0.05 considered suggestive evidence for association. There elevated higher AD risks. odds ratio (OR) 1.311 [95% confidence interval (CI), 1.087-1.580; = 0.004] per one standard deviation increase in concentrations. support protective effect (OR 0.607; 95% CI, 0.396-0.932; 0.022). Genetically glycine not risk 1.145; 0.939-1.396; 0.180). Besides, indicated no roles or In conclusion, provided supporting increased lower Triangulating across further designs is still warranted elucidate role

Язык: Английский

Процитировано

5
The Anti-Aggregative Peptide KLVFF Mimics Aβ1-40 in the Modulation of Nicotinic Receptors: Implications for Peptide-Based Therapy DOI Creative Commons
Hanna Trebesova, Guendalina Olivero, Mario Marchi

и другие.

Biomedicines, Год журнала: 2022, Номер 10(9), С. 2231 - 2231

Опубликована: Сен. 8, 2022

In recent years, the inhibition of beta-amyloid (Aβ) aggregation has emerged as a potential strategy for Alzheimer's disease. KLVFF, small peptide corresponding to aminoacidic sequence 16-20 Aβ, reduces Aβ fibrillation dose dependently. Therefore, toxic and functional characterization its brain activity is fundamental clarifying therapeutic role. Accordingly, we studied modulatory role KLVFF on cholinergic receptors regulating dopamine noradrenaline release in rat synaptosomes. Nicotinic dopaminergic nerve terminals nucleus acccumbens are inhibited by which closely resembles full-length Aβ1-40. Moreover, entrapped synaptosomes does not modify nicotinic receptor's function, suggesting that external binding receptor required activity. The agent desformylflustrabromine counteracts effect. Remarkably, muscarinic hippocampus completely insensitive KLVFF. Based our findings, mimics Aβ1-40 negative modulator specific subtypes affecting transmission brain. new pharmacological strategies using anti-aggregative properties need be evaluated interference with receptor-mediated transmission.

Язык: Английский

Процитировано

3