SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Promote a Proinflammatory Activation Profile on Human Dendritic Cells DOI Creative Commons
Dante Barreda, César Santiago, Juan Rodríguez

и другие.

Cells, Год журнала: 2021, Номер 10(12), С. 3279 - 3279

Опубликована: Ноя. 23, 2021

Dendritic cells (DCs) are the most potent antigen-presenting cells, and their function is essential to configure adaptative immunity avoid excessive inflammation. DCs predicted play a crucial role in clinical evolution of infection by severe acute respiratory syndrome (SARS) coronavirus (CoV)-2. interaction with SARS-CoV-2 Spike protein, which mediates cell receptor binding subsequent fusion viral particle host cell, key step induce effective against this virus S protein-based vaccination protocols. Here we evaluated human response or fragment encompassing domain (RBD) challenge. Both proteins increased expression maturation markers, including MHC molecules costimulatory receptors. protein promotes activation signaling involved inflammation, MAPK, AKT, STAT1, NFκB, correlates secretion distinctive proinflammatory cytokines. Differences ACE2 along differentiation monocytes mature inter-donor were found. Our results show that inflammatory provides molecular links between individual variations degree virus.

Язык: Английский

COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials DOI
Seshadri Reddy Varikasuvu,

Balachandar Thangappazham,

Alekya Vykunta

и другие.

Expert Review of Anti-infective Therapy, Год журнала: 2022, Номер 20(6), С. 907 - 913

Опубликована: Янв. 28, 2022

Introduction Vitamin D levels have been reported to be associated with COVID-19 susceptibility, severity, and mortality events. We performed a meta-analysis of randomized controlled trials (RCTs) evaluate the use vitamin intervention on outcomes.Areas covered Literature search was conducted using PubMed, Cochrane library, ClinicalTrials.gov databases. included RCTs reporting control/placebo group in COVID-19. The study registered at PROSPERO: CRD42021271461.Expert opinion A total 6 551 patients were included. overall collective evidence pooling all outcomes across indicated beneficial (relative risk, RR = 0.60, 95% CI 0.40 0.92, Z 2.33, p 0.02, I2 48%). rates RT-CR positivity significantly decreased as compared non-vitamin groups (RR 0.46, 0.24 0.89, 2.31, 0%). Conclusively, supplemented are more likely demonstrate fewer ICU admission, events, RT-PCR positivity.

Язык: Английский

Процитировано

76
Geroscience and pathology: a new frontier in understanding age-related diseases DOI Creative Commons
Mónika Fekete, Dávid Major,

Ágnes Fehér

и другие.

Pathology & Oncology Research, Год журнала: 2024, Номер 30

Опубликована: Фев. 23, 2024

Geroscience, a burgeoning discipline at the intersection of aging and disease, aims to unravel intricate relationship between process pathogenesis age-related diseases. This paper explores pivotal role played by geroscience in reshaping our understanding pathology, with particular focus on These diseases, spanning cardiovascular cerebrovascular disorders, malignancies, neurodegenerative conditions, significantly contribute morbidity mortality older individuals. We delve into fundamental cellular molecular mechanisms underpinning aging, including mitochondrial dysfunction senescence, elucidate their profound implications for various Emphasis is placed importance assessing key biomarkers biological age within realm pathology. also scrutinize interplay senescence cancer biology as central area focus, underscoring its paramount significance contemporary pathological research. Moreover, we shed light integration anti-aging interventions that target processes, such senolytics, mitochondria-targeted treatments, influence epigenetic regulation domain pathology In conclusion, concepts research heralds transformative paradigm shift disease promises breakthroughs prevention treatment.

Язык: Английский

Процитировано

28
Immunosenescence and COVID-19 DOI Open Access
Jacek M. Witkowski, Tamàs Fülöp, Ewa Bryl

и другие.

Mechanisms of Ageing and Development, Год журнала: 2022, Номер 204, С. 111672 - 111672

Опубликована: Апрель 2, 2022

Язык: Английский

Процитировано

55
Risk factors for severe COVID-19 differ by age for hospitalized adults DOI Creative Commons
Sevda Molani, Patricia V. Hernandez, Ryan Roper

и другие.

Scientific Reports, Год журнала: 2022, Номер 12(1)

Опубликована: Апрель 28, 2022

Abstract Risk stratification for hospitalized adults with COVID-19 is essential to inform decisions about individual patients and allocation of resources. So far, risk models severe COVID outcomes have included age but not been optimized best serve the needs either older or younger adults. Models also need be updated reflect improvements in treatments. This retrospective study analyzed data from 6906 a community health system across five states western United States. were developed predict mechanical ventilation illness death one 56 days hospitalization, using clinical available within first hour after admission positive SARS-CoV-2 test. For seven-day interval, ≥ 18 < 50 years reached AUROC 0.81 (95% CI 0.71–0.91) 0.82 0.77–0.86). revealed differences statistical significance relative predictive value factors between including age, BMI, vital signs, laboratory results. In addition, patients, sex chronic comorbidities had lower than signs

Язык: Английский

Процитировано

43
Oral dysbiosis and its linkage with SARS-CoV-2 infection DOI Creative Commons
Abhishek Gupta, Shivang Bhanushali, Avinash Sanap

и другие.

Microbiological Research, Год журнала: 2022, Номер 261, С. 127055 - 127055

Опубликована: Май 4, 2022

Язык: Английский

Процитировано

32
SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147 DOI Creative Commons

Shaimaa Shouman,

Nada Elkholy,

Alaa E. Hussien

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 4, 2024

T lymphocytes play a primary role in the adaptive antiviral immunity. Both lymphocytosis and lymphopenia were found to be associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While indicates an active anti-viral response, is sign of poor prognosis. T-cells, essence, rarely express ACE2 receptors, making cause cell depletion enigmatic. Moreover, emerging strains posed immunological challenge, potentially alarming for next pandemic. Herein, we review how possible indirect direct key mechanisms could contribute SARS-CoV-2-associated-lymphopenia. The fundamental mechanism inflammatory cytokine storm elicited by viral infection, which alters host metabolism into more acidic state. This "hyperlactic acidemia" together suppresses T-cell proliferation triggers intrinsic/extrinsic apoptosis. SARS-CoV-2 infection also results shift from steady-state hematopoiesis stress hematopoiesis. Even low expression, presence cholesterol-rich lipid rafts on activated T-cells may enhance entry syncytia formation. Finally, indicate participation other receptors or auxiliary proteins that can work alone concert mechanisms. Therefore, address CD147-a novel route-for its new variants. CD147 not only expressed but it interacts co-partners orchestrate various biological processes. Given these features, appealing candidate pathogenicity. Understanding molecular cellular behind SARS-CoV-2-associated-lymphopenia will aid discovery potential therapeutic targets improve resilience our immune system against this rapidly evolving virus.

Язык: Английский

Процитировано

7
Severity of coronavirus disease 19: Profile of inflammatory markers and ACE (rs4646994) and ACE2 (rs2285666) gene polymorphisms in Iraqi patients DOI
Zainab Mahmood, Hula Y. Fadhil, Thaer Ali Hussein

и другие.

Meta Gene, Год журнала: 2022, Номер 31, С. 101014 - 101014

Опубликована: Янв. 10, 2022

Язык: Английский

Процитировано

26
Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework DOI Open Access
Laure‐Alix Clerbaux, Maria Cristina Albertini, Núria Amigó

и другие.

Journal of Clinical Medicine, Год журнала: 2022, Номер 11(15), С. 4464 - 4464

Опубликована: Июль 31, 2022

Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows that outcomes are markedly heterogeneous between patients. This requires identifying the and understanding how they mechanistically influence COVID-19. Here, we describe eleven selected (age, sex, genetic factors, lipid disorders, heart failure, gut dysbiosis, diet, vitamin D deficiency, air pollution exposure to chemicals) by applying Adverse Outcome Pathway (AOP), which well-established in regulatory toxicology. framework aims model sequence of events leading an adverse health outcome. Several linear AOPs depicting pathways from binding virus ACE2 up observed have been developed integrated into a network offering unique overview mechanisms underlying disease. As SARS-CoV-2 infectibility activity major starting points inflammatory response central development COVID-19, evaluated those intrinsic extrinsic modulate processes impacting outcomes. Applying this AOP-aligned approach enables identification current knowledge gaps orientating for further research allows propose biomarkers identify high-risk also facilitates expertise synergy different disciplines address public issues.

Язык: Английский

Процитировано

23
The Coverage and Acceptance Spectrum of COVID-19 Vaccines among Healthcare Professionals in Western Tanzania: What Can We Learn from This Pandemic? DOI Creative Commons
Eveline T. Konje, Namanya Basinda, Anthony Kapesa

и другие.

Vaccines, Год журнала: 2022, Номер 10(9), С. 1429 - 1429

Опубликована: Авг. 30, 2022

The vaccination rate against COVID-19 remains low in developing countries due to vaccine hesitancy. Vaccine hesitancy is a public health threat curbing pandemic globally. Healthcare professionals have been found play critical role advocacy and promotion campaigns the general population. A cross sectional study was conducted initial months of roll out program Tanzania determine acceptance rate, perceived barriers, cues for actions. total 811 healthcare participated from 26 facilities western Tanzania. World Health Organization (WHO) questionnaire adopted with minor modifications capture local contexts used data collection. Only (18.5%) had received 29%. majority (62%) participants were stage issues related lack effective communication reliable information regarding efficacy safety. In this era pandemic, there need engage involve figures opinion leaders through transparent dialogue clarify vaccine-related safety, quality, efficacy. These strategies will reduce misconception, mistrust, improve uptake among eventually

Язык: Английский

Процитировано

23
Potential interaction between the oral microbiota and COVID-19: a meta-analysis and bioinformatics prediction DOI Creative Commons
Li Tan,

Meng‐Mei Zhong,

Qiong Liu

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13

Опубликована: Июнь 7, 2023

The purpose of this study was to evaluate available evidence on the association between human oral microbiota and coronavirus disease 2019 (COVID-19) summarize relevant data obtained during pandemic.

Язык: Английский

Процитировано

14