Androgens as the “old age stick” in skeletal muscle

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 3, 2025

Язык: Английский

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Association of hematological parameters and inflammatory indices with sarcopenia in the United States and China: a cross-sectional study

European journal of medical research, Год журнала: 2025, Номер 30(1)

Опубликована: Апрель 15, 2025

In this study, we examined the association between hematological parameters and inflammatory indices sarcopenia in general population of United States China. The cross-sectional study was conducted using data from National Health Nutrition Examination Survey (NHANES) (2011-2014) Affiliated Hospital Anhui Medical University (2022-2024). We employed weighted restricted cubic spline (RCS) plots multivariable logistic regression analyses to explore with prevalence American Chinese populations. A total 8805 participants NHANES, 2598 individuals First were included our analysis. populations, roughly J-shaped curve detected RCS for mean platelet volume platelet-to-lymphocyte ratio risk sarcopenia. Additionally, positively linearly associated white blood cells, lymphocytes platelet, while it inversely cell volume. demonstrated a nonlinear some parameters, need focus more on body could provide better prevention strategies

Язык: Английский

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Identification of novel pathways and immune profiles related to sarcopenia

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Апрель 17, 2023

Sarcopenia is a progressive deterioration of skeletal muscle mass strength and function.To uncover the underlying cellular biological mechanisms, we studied association between sarcopenia's three stages patient's ethnicity, identified gene regulatory network based on motif enrichment in upregulated set sarcopenia, compared immunological landscape among sarcopenia stages.We found that (S) was associated with GnRH, neurotrophin, Rap1, Ras, p53 signaling pathways. Low (LMM) patients showed activated pathways VEGF signaling, B-cell receptor ErbB T-cell signaling. physical performance (LMM_LP) lower scores apoptosis, HIF-1 adaptive immune response Five common genes DEGs elastic net regression model, TTC39DP, SLURP1, LCE1C, PTCD2P1, OR7E109P, were expressed S healthy controls. SLURP1 LCE1C highest expression levels sarcopenic Chinese descent than Caucasians Afro-Caribbeans. Gene analysis top yielded top-scoring regulon containing GATA1, GATA2, GATA3 as master regulators nine predicted direct target genes. Two locomotion: POSTN SLURP1. TTC39DP upregulation better prognosis stronger profile patients. The worse weaker profile.This study provides new insight into prospects evaluates age sarcopenia-related modifications muscle.

Язык: Английский

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The impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer after curative surgery

BMC Cancer, Год журнала: 2023, Номер 23(1)

Опубликована: Июль 10, 2023

Abstract Background The impact of sarcopenia on the outcome patients with left-sided colon and rectal cancer has not been exhaustively investigated. Thus, present study was performed to evaluate effect cancer. Methods Patients pathologically diagnosed stage I, II III or who had undergone curative surgery between January 2008 December 2014 were retrospectively reviewed. psoas muscle index (PMI) identified by 3D-image analysis computed tomographic images criterion used diagnose sarcopenia. cut-off value recommended Hamaguchi (PMI < 6.36 cm 2 /m for men 3.92 women) adopted confirm diagnosis According PMI, each patient divided into group (SG) nonsarcopenia (NSG). Then, SG compared NSG in terms postoperative outcomes. Results Among 939 included, 574 (61.1%) confirmed have preoperative Initially, it demonstrated that significantly different from most baseline characteristics except a lower body mass (BMI) ( P 0.001), larger tumour size 0.001) more weight loss (more than 3 kg last three months) = 0.033). longer hospital stay after 0.040), intraoperative blood transfusions 0.035), higher incidence anastomotic fistula 0.027), surgical site infection (SSI) 0.037) hypoalbuminemia 0.022), 30-day mortality 0.042) 90-day 0.041). worse overall survival (OS) 0.016) recurrence-free (RFS) 0.036) NSG. Subsequently, Cox regression revealed an independent predictive factor OS 0.0211, HR 1.367, 95% CI: 1.049–1.782) RFS 0.045, 1.299, 1.006–1.677). Conclusion Preoperative adversely affects cancer, nutrition supplementation may help us improve their long-term short-term

Язык: Английский

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Prognostic Value of Body Composition and Systemic Inflammatory Markers in Patients with Locally Advanced Cervical Cancer Following Chemoradiotherapy

Journal of Inflammation Research, Год журнала: 2023, Номер Volume 16, С. 5145 - 5156

Опубликована: Ноя. 1, 2023

Abnormal changes in body composition and systemic inflammation response have been associated with poor survival of cancer patients. Our study was to explore the prognostic value association between indicators markers among patients locally advanced cervical (LACC) who underwent concurrent chemoradiotherapy (CCRT).We retrospectively reviewed medical records LACC treated 2016 2019. Subcutaneous, visceral intra-muscular adipose index (SAI, VAI IMAI) skeletal muscle (SMI) were derived from computed tomography (CT). Kaplan-Meier analysis Univariate multivariate Cox analyses used evaluate survival. A nomogram constructed assess value.The included 196 CCRT. According multivariable analyses, IIIC1r (P = 0.045), high immune-inflammation (SII) 0.004), sarcopenia 0.008), SAI 0.016) 0.001) significantly risk factors for overall (OS). showed that low lymphocyte-to-monocyte ratio (LMR) had longer OS than those LMR 0.023). The neutrophil-to-lymphocyte (NLR) non-sarcopenic better 0.022). Low 0.019) or IMAI combined SII a favorable OS. calibration plots predicting 3-year 5-year rates close ideal models.Inflammation closely abnormal fat distribution. reliable

Язык: Английский

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