Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 27, 2023
Abstract
Background
Hypertension
is
a
kind
of
clinical
syndrome,
characterized
by
the
increase
systemic
arterial
pressure.
There
lack
identifiable
triggers
and
predictors
hypertensive
disease
in
response
to
treatment
at
rest
during
exercise.
In
this
study,
mathematical
model
was
used
screen
compare
indicators
related
changes
exercise
between
normotensive
individuals.
Methods
Blood
pressure
ultrasound-related
indicators,
blood
biochemical
metabolic
compounds
were
collected
logistic
regression
Principal
component
analysis
(PCA)
explore
differences
indexes
different
states
healthy
patients.
An
indicator
change
map
for
hypertension
established.
Results
The
results
reveal
that
not
only
oxidative
stress,
inflammatory
reaction
fatty
acid
oxidation,
but
also
involves
various
amino
metabolism.
defined
models
might
be
helpful
early
screening
future
studies
are
needed
their
value
on
prevention
control
hypertension.
Conclusion
research
shows
main
regulation
differ
significantly
normal
group
group.
key
ultrasound
while
those
metabolites
lactic
metabolism,
glycolysis,
aerobic
oxidation
lipid
Journal of Cachexia Sarcopenia and Muscle,
Год журнала:
2024,
Номер
15(5), С. 2175 - 2186
Опубликована: Авг. 21, 2024
The
pathophysiology
of
sarcopenia
is
complex
and
multifactorial
has
not
been
fully
elucidated.
impact
resistance
training
nutritional
support
(RTNS)
on
metabolomics
lipodomics
in
older
adults
with
remains
uncertain.
This
study
aimed
to
explore
potential
biomarkers
clinical
indicators
RTNS
sarcopenic
adults.
Nutrients,
Год журнала:
2023,
Номер
15(10), С. 2400 - 2400
Опубликована: Май 21, 2023
This
study
aimed
to
identify
the
serum
metabolites
associated
with
sarcopenic
risk
in
Japanese
patients
type
2
diabetes,
determine
effect
of
dietary
protein
intake
on
metabolic
profile,
and
examine
its
association
sarcopenia.
Ninety-nine
diabetes
were
included,
was
defined
as
low
muscle
mass
or
strength.
Seventeen
quantified
after
gas
chromatography–mass
spectrometry
analysis.
The
relationship
between
concerning
sarcopenia
analyzed,
factors
affecting
clarified.
Twenty-seven
classified
being
at
sarcopenia,
same
general
risk,
which
older
age,
a
longer
duration
disease,
lower
body
index.
Low
levels
leucine
glutamic
acid
significantly
strength
(p
=
0.002
p
<
0.001,
respectively),
also
0.001).
Lower
had
higher
odds
adjusted
for
age
HbA1c
(adjusted
OR
4.27,
95%
CI
1.07–17.11,
0.041),
but
not
leucine.
Leucine
can
serve
useful
biomarkers
highlighting
potential
targets
prevention.
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
The
proportion
of
the
elderly
population
is
gradually
increasing
as
a
result
medical
care
advances,
leading
to
subsequent
surge
in
geriatric
diseases
that
significantly
impact
quality
life
and
pose
substantial
healthcare
burden.
Sarcopenia,
characterized
by
age-related
decline
skeletal
muscle
mass
quality,
affects
considerable
portion
older
adults,
particularly
elderly,
can
adverse
outcomes
such
frailty,
fractures,
bedridden,
hospitalization,
even
mortality.
Skeletal
aging
accompanied
underlying
metabolic
changes.
Therefore,
elucidating
these
profiles
specific
mechanisms
holds
promise
for
informing
prevention
treatment
strategies
sarcopenia.
This
review
provides
comprehensive
overview
key
metabolites
identified
current
clinical
studies
on
sarcopenia
their
potential
pathophysiological
alterations
activity.
Besides,
we
examine
therapeutic
from
perspective
focused
regulation.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 19, 2024
Background
Untargeted
metabonomics
has
provided
new
insight
into
the
pathogenesis
of
sarcopenia.
In
this
study,
we
explored
plasma
metabolic
signatures
linked
to
a
heightened
risk
sarcopenia
in
cohort
study
by
LC-MS-based
untargeted
metabonomics.
Methods
nested
case–control
from
Adult
Physical
Fitness
and
Health
Cohort
Study
(APFHCS),
collected
blood
samples
30
new-onset
subjects
(mean
age
73.2
±
5.6
years)
healthy
controls
74.2
4.6
matched
age,
sex,
BMI,
lifestyle,
comorbidities.
An
metabolomics
methodology
was
employed
discern
metabolomic
profile
alterations
present
individuals
exhibiting
newly
diagnosed
Results
comparing
with
normal
controls,
comprehensive
analysis
using
liquid
chromatography-mass
spectrometry
(LC-MS)
identified
total
62
metabolites,
predominantly
comprising
lipids,
lipid-like
molecules,
organic
acids,
derivatives.
Receiver
operating
characteristic
(ROC)
curve
indicated
that
three
metabolites
hypoxanthine
(AUC=0.819,
95%
CI=0.711–0.927),
L-2-amino-3-oxobutanoic
acid
(AUC=0.733,
CI=0.598–0.868)
PC(14:0/20:2(11Z,14Z))
(AUC=
0.717,
CI=0.587–0.846)
had
highest
areas
under
curve.
Then,
these
significant
were
observed
be
notably
enriched
four
distinct
pathways,
namely,
“purine
metabolism”;
“parathyroid
hormone
synthesis,
secretion
action”;
“choline
metabolism
cancer”;
“tuberculosis”.
Conclusion
The
current
investigation
elucidates
perturbations
hold
promise
as
potential
biomarkers,
offering
avenues
for
exploring
underlying
pathological
mechanisms
associated
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Sarcopenia
(SP),
an
age‐associated
condition
marked
by
muscle
weakness
and
loss
has
been
strongly
connected
with
metabolic
factors
according
to
substantial
evidence.
Nevertheless,
the
causal
correlation
between
SP
serum
metabolites,
biological
signaling
pathways
involved,
is
still
not
well
understood.
We
performed
a
bidirectional
two‐sample
Mendelian
randomization
(MR)
analysis
examine
relationships
1091
levels
309
ratios
of
metabolites
traits,
alongside
investigating
relevant
pathways.
Additionally,
we
explored
differential
expression
plasma
potential
in
animal
model
SP.
When
was
utilized
as
outcome,
identified
11
robust
associations
seven
metabolite
levels/ratios
SP‐related
traits
using
Bonferroni's
correction
(threshold:
p
<
0.05).
verified
stable
association
glycine
validation.
As
for
reverse
MR
analysis,
there
were
strong
remaining
after
multiple
contrast
correction.
pathway
showed
that
metabolism,
insulin
resistance,
cAMP
may
contribute
connection
validation
various
datasets
observations
metabolomics
suggests
metabolism
Our
results
indicate
biosignaling
could
serve
important
circulatory
biomarkers
screening
prevention
clinical
settings.
they
represent
molecules
future
exploration
mechanisms
selection
drug
targets.
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Март 12, 2025
The
intricate
relationship
between
bile
acid
metabolism
and
skeletal
muscle
function
has
emerged
as
a
crucial
area
of
research
in
metabolic
health.
This
review
synthesizes
current
evidence
highlighting
the
fundamental
role
acids
key
signaling
molecules
homeostasis
their
therapeutic
potential
muscle-related
disorders.
Recent
advances
molecular
biology
metabolomics
have
revealed
that
acids,
beyond
classical
lipid
absorption,
essential
regulators
mass
through
multiple
pathways,
particularly
via
nuclear
receptor
FXR
membrane
TGR5.
Clinical
studies
demonstrated
significant
associations
altered
profiles
wasting
conditions,
while
experimental
elucidated
underlying
mechanisms
linking
to
protein
synthesis,
energy
metabolism,
regeneration
capacity.
We
critically
examine
emerging
strategies
targeting
including
receptor-specific
agonists,
microbiome
modulators,
personalized
interventions
based
on
individual
profiles.
Additionally,
we
discuss
novel
diagnostic
approaches
utilizing
acid-based
biomarkers
early
detection
monitoring
also
addresses
challenges
standardization
clinical
translation
promising
future
directions
this
rapidly
evolving
field.
Understanding
acid-muscle
axis
may
provide
new
opportunities
for
developing
targeted
therapies
age-related
loss
diseases.
Metabolites,
Год журнала:
2025,
Номер
15(5), С. 334 - 334
Опубликована: Май 19, 2025
Background:
Walking
ability
is
important
for
the
quality
of
life
older
adults.
A
self-reported
walking
index
(WAI)
covering
difficulty
and
ease
captures
a
broader
spectrum
in
healthy
persons.
Methods:
Using
metabolomics
Health,
Aging
Body
Composition
study,
we
identified
Year
2
metabolites
cross-sectionally
longitudinally
related
to
WAI
(0–9,
higher
scores
indicate
better
ability)
using
probabilistic
models
multinomial
logistic
models,
respectively.
Results:
Among
2334
participants
(mean
age
74.6
years,
51%
women,
37%
Black),
27%
scored
0–5,
36%
6–8,
9
at
2.
Over
4
52%
maintained
stable
WAI,
6%
improved,
while
42%
declined
(22%
1–2
points
20%
>2
decline).
We
81
significantly
associated
with
both
poorer
concurrent
faster
decline,
including
acylcarnitine
species,
shorter-chain
saturated
diglycerides
triglycerides,
TCA
cycle
intermediates
(cis-aconitic,
fumaric,
malic
acids),
lower
phospholipids
levels.
Eighteen
additional
were
only
decline:
short-chain
triglycerides
energy
metabolism
markers
(ATP/ADP/AMP)
margaric
acid
glycine
Notably,
those
improved
despite
baseline
lifestyles,
showed
more
favorable
metabolic
profiles
than
others.
Conclusions:
Metabolites
linked
metabolism,
as
well
inflammation
protein
catabolism,
mobility
function.
Some
might
be
particularly
early
detection
adults
risk
decline.
Metabolic
may
also
help
identify
individuals
(i.e.,
improving
WAI)
greater
resilience
lifestyle
factors
health
conditions.
Metabolites,
Год журнала:
2024,
Номер
14(7), С. 379 - 379
Опубликована: Июль 7, 2024
Over
the
millennia,
patterns
of
food
consumption
have
changed;
however,
foods
were
always
whole
foods.
Ultra-processed
(UPFs)
been
a
very
recent
development
and
become
primary
source
for
many
people.
The
purpose
this
review
is
to
propose
hypothesis
that,
forsaking
evolutionary
dietary
environment,
its
complex
milieu
compounds
resulting
in
an
extensive
metabolome,
contributes
chronic
disease
modern
humans.
This
metabolome
may
contributed
success
early
hominins.
based
on
following
assumptions:
(1)
promote
health,
(2)
essential
nutrients
cannot
explain
all
benefits
foods,
(3)
UPFs
are
much
lower
phytonutrients
other
compared
(4)
diets
more
diverse
metabolome.
Evidence
will
be
presented
support
hypothesis.
Nutrition
matter
systems
biology,
investigating
as
humans,
help
elucidate
hidden
connections
between
diet
health.
effect
also
shape
future
guidelines,
define
healthy
