Frontiers in Psychiatry,
Год журнала:
2025,
Номер
16
Опубликована: Май 14, 2025
Background
Appetite
loss
is
common
in
major
depressive
disorder
(MDD).
However,
the
psychosocial
and
biological
mechanisms
behind
appetite
remain
unclear,
particularly
adolescent
MDD
population.
Therefore,
this
study
aimed
to
examine
links
between
clinical
symptoms
as
well
inflammatory
cytokines
levels
Methods
Between
January
December
2021,
included
171
depressed
adolescents.
A
range
of
scales
were
used
assess
patients’
symptoms,
including
depression
severity,
negative
life
events,
insomnia,
alexithymia.
Additionally,
plasma
measured,
interleukin
(IL)-1β,
IL-6,
IL-10,
IL-17A
tumor
necrosis
factor-α
(TNF-α).
Results
The
prevalence
among
adolescents
with
was
high
76.0%.
Univariate
analyses
showed
that
patients
had
higher
scores
Hamilton
Depression
Scale
(HAMD),
interpersonal
relationships,
pressure,
punishment,
sense
loss,
Insomnia
Severity
Index
(ISI)
difficulty
identifying
feelings,
Log
IL-6
(all
p
<
0.05)
Furthermore,
regression
revealed
independently
associated
HAMD
score
(OR
=
1.158,
95%
CI
1.091-1.229,
0.001),
punishment
1.117,
1.039-1.201,
0.003),
level
5.041,
1.137-22.344,
0.033).
Conclusion
Adolescents
face
an
elevated
risk
which
may
correlate
such
severity
level.
Healthcare
professionals
should
target
these
factors,
inflammation,
mitigate
loss.
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Март 10, 2025
Introduction
Depression
is
a
psychological
condition
characterized
by
persistent
low
mood.
This
study
investigates
the
relationship
between
depressive
symptoms
and
food
preferences
in
undergraduate
students.
Methods
A
cross-sectional
design
was
employed
among
502
students
at
Zanjan
University
of
Medical
Sciences.
Data
collection
included
validated
questionnaires
on
preferences,
depression
levels
(Beck
Inventory),
physical
activity
(IPAQ),
along
with
anthropometric
measurements.
Food
were
analyzed
for
six
groups:
grains,
fruits,
vegetables,
dairy,
meat/fish,
snacks.
severity
categorized
into
based
BDI
scores:
normal
(1–9),
mild
(10–16),
borderline
(17–20),
moderate
(21–30),
severe
(31–40),
very
(41–63).
risk
defined
as
odds
belonging
to
higher
Beck
Inventory
(BDI)
category.
Results
Participants
had
lower
vegetables
but
Adjusted
analyses
revealed
that
fruits
(OR:
0.79;
95%
CI:
0.68–0.98)
0.81;
0.71–0.94)
significantly
associated
reduced
risk,
while
snack
increased
1.28;
1.03–1.68).
However,
association
grain
not
statistically
significant
after
adjustment
0.82;
0.74–1.03).
Conclusion
These
findings
highlight
bidirectional
link
diet
mental
health,
underscoring
importance
dietary
interventions
health
strategies.
World Journal of Psychiatry,
Год журнала:
2025,
Номер
15(5)
Опубликована: Апрель 30, 2025
BACKGROUND
The
assessment
of
nutritional
status
in
non-dialysis
elderly
patients
with
chronic
kidney
disease
(CKD)
and
comorbid
depression
is
clinically
important.
Determining
key
determinants
this
population
significantly
improves
management
strategies
assists
these
overcome
the
disease.
AIM
To
investigate
factors
influencing
CKD
depression.
METHODS
This
study
retrospectively
collected
clinical
data
182
admitted
at
Tangdu
Hospital,
Air
Force
Medical
University,
from
January
2022
to
June
2023.
participants
were
categorized
based
on
presence
malnutrition
into
nutritionally
normal
group
(n
=
97)
85).
two
groups
subjected
unifactorial
multifactorial
regression
analyze
among
participants.
Data
included
sex,
age,
body
mass
index
(BMI),
percentage
fat,
basal
metabolic
rate
(BMR),
blood
urea
nitrogen
(BUN),
creatinine
(Cr),
albumin
(Alb),
hemoglobin
(Hb),
pre-albumin
(PA),
patient-generated
subjective
global
assessment,
Patient
Health
Questionnaire-9
(PHQ-9)
score
identify
depressive
symptoms.
After
admitting
hospital,
5
mL
peripheral
serum
was
withdrawn,
centrifuge
operated
3500
rpm/minute
a
centrifugal
radius
10
cm
for
minutes,
collected,
Alb,
Hb,
PA,
BUN,
Cr
levels
detected
using
fully
automatic
biochemical
analyzer.
results
assessed
Statistical
Package
Social
Sciences
version
21.0
conducting
technical
analyses.
Metric
are
presented
as
mean
±
standard
error
replaced
t
-test.
Count
expressed
case
counts
percentages
χ
2
test.
Effective
modeled
logistic
return
modeling.
RESULTS
BMI,
BMR,
lower
than
group.
Furthermore,
BUN
levels,
PHQ-9
scores,
anxiety
symptoms
greater
nutrition
group,
statistically
significant
differences
(P
<
0.05).
Multiple
factorial
interpretations
revealed
PA
CONCLUSION
Serum
all
depression;
hence,
interventions
can
be
targeted
above
characteristics.
Biomedicines,
Год журнала:
2025,
Номер
13(5), С. 1129 - 1129
Опубликована: Май 7, 2025
Background/Objectives:
Major
depressive
disorder
(MDD)
is
a
major
global
health
concern
that
intimately
linked
to
neuroinflammation,
oxidative
stress,
mitochondrial
dysfunction,
and
complicated
metabolic
abnormalities.
Traditional
antidepressants
frequently
fall
short,
highlighting
the
urgent
need
for
new,
safer,
more
acceptable
therapeutic
techniques.
Phytochemicals,
i.e.,
natural
derived
from
plants,
are
emerging
as
powerful
plant-based
therapies
capable
of
targeting
many
pathogenic
pathways
at
same
time.
Summary:
This
narrative
review
synthesizes
evidence
preclinical
clinical
studies
on
efficacy
phytochemicals
such
curcumin,
polyphenols,
flavonoids,
alkaloids
in
lowering
depressed
symptoms.
Consistent
data
show
these
substances
have
neuroprotective,
anti-inflammatory,
antioxidant
properties,
altering
neuroimmune
interactions,
reducing
damage,
improving
resilience.
Particularly,
polyphenols
flavonoids
great
potential
because
their
capacity
penetrate
blood–brain
barrier,
inhibit
cytokine
activity,
encourage
neuroplasticity
mediated
by
brain-derived
neurotrophic
factor
(BDNF).
Despite
promising
results,
heterogeneity
study
designs,
phytochemical
formulations,
patient
demographics
highlights
importance
thorough,
standardized
studies.
Conclusions:
identifies
compelling
adjuvant
or
independent
depression
treatment,
providing
multimodal
mechanisms
enhanced
tolerability.
Additional
research
into
improved
dosage,
pharmacokinetics,
long-term
safety,
integrative
therapy
approaches
essential.
Using
phytotherapeutics
could
considerably
improve
holistic
customized
care,
encouraging
new
routes
neuroscience
psychiatry.
Frontiers in Psychiatry,
Год журнала:
2025,
Номер
16
Опубликована: Май 14, 2025
Background
Appetite
loss
is
common
in
major
depressive
disorder
(MDD).
However,
the
psychosocial
and
biological
mechanisms
behind
appetite
remain
unclear,
particularly
adolescent
MDD
population.
Therefore,
this
study
aimed
to
examine
links
between
clinical
symptoms
as
well
inflammatory
cytokines
levels
Methods
Between
January
December
2021,
included
171
depressed
adolescents.
A
range
of
scales
were
used
assess
patients’
symptoms,
including
depression
severity,
negative
life
events,
insomnia,
alexithymia.
Additionally,
plasma
measured,
interleukin
(IL)-1β,
IL-6,
IL-10,
IL-17A
tumor
necrosis
factor-α
(TNF-α).
Results
The
prevalence
among
adolescents
with
was
high
76.0%.
Univariate
analyses
showed
that
patients
had
higher
scores
Hamilton
Depression
Scale
(HAMD),
interpersonal
relationships,
pressure,
punishment,
sense
loss,
Insomnia
Severity
Index
(ISI)
difficulty
identifying
feelings,
Log
IL-6
(all
p
<
0.05)
Furthermore,
regression
revealed
independently
associated
HAMD
score
(OR
=
1.158,
95%
CI
1.091-1.229,
0.001),
punishment
1.117,
1.039-1.201,
0.003),
level
5.041,
1.137-22.344,
0.033).
Conclusion
Adolescents
face
an
elevated
risk
which
may
correlate
such
severity
level.
Healthcare
professionals
should
target
these
factors,
inflammation,
mitigate
loss.
