CCL5 Induces a Sarcopenic-like Phenotype via the CCR5 Receptor
Antioxidants,
Год журнала:
2025,
Номер
14(1), С. 84 - 84
Опубликована: Янв. 13, 2025
Sarcopenia
corresponds
to
a
decrease
in
muscle
mass
and
strength.
CCL5
is
new
myokine
whose
expression,
along
with
the
CCR5
receptor,
increased
sarcopenic
muscle.
Therefore,
we
evaluated
whether
induce
sarcopenic-like
effect
on
skeletal
tissue
cultured
cells.
Electroporation
tibialis
anterior
(TA)
of
mice
was
used
overexpress
CCL5.
The
TA
muscles
were
analyzed
by
measuring
fiber
diameter,
content
sarcomeric
proteins,
gene
expression
E3-ligases.
C2C12
myotubes
single-isolated
flexor
digitorum
brevis
(FDB)
fibers
also
treated
recombinant
(rCCL5).
participation
using
antagonist
maraviroc
(MVC).
Protein
structural
analyses
performed.
results
showed
that
overexpression
led
sarcopenia
reducing
strength
mass,
muscle-fiber
protein
content,
upregulating
same
phenotype
observed
FDB
fibers.
We
reactive
oxygen
species
(ROS)
production
carbonylated
denoting
oxidative
stress
induced
When
antagonized,
effects
produced
rCCL5
prevented.
In
conclusion,
report
for
first
time
novel
exerts
through
receptor.
Язык: Английский
ICU-acquired weakness in critically ill patients at risk of malnutrition: risk factors, biomarkers, and early enteral nutrition impact
World Journal of Emergency Medicine,
Год журнала:
2025,
Номер
16(1), С. 51 - 51
Опубликована: Янв. 1, 2025
This
study
aimed
to
explore
the
risk
factors
associated
with
intensive
care
unit-acquired
weakness
(ICU-AW)
in
critically
ill
patients
at
of
malnutrition
and
evaluate
efficacy
early
enteral
nutrition
(EEN)
role
biomarkers
managing
ICU-AW.
retrospective,
observational
cohort
included
180
admitted
emergency
unit
First
Affiliated
Hospital
Xiamen
University
from
January
2022
December
2023.
Patients
were
divided
into
ICU-AW
group
non-ICU-AW
according
whether
they
developed
ICU-AW,
or
categorized
EEN
parenteral
(PN)
groups
nutritional
support.
was
diagnosed
using
Medical
Research
Council
score.
The
primary
outcome
occurrence
significant
age,
sex,
type
therapy,
mechanical
ventilation
(MV),
body
mass
index
(BMI),
blood
urea
nitrogen
(BUN),
creatinine
(Cr)
levels
(P<0.05).
PN
earlier
than
did
group,
a
difference
observed
(log-rank
P<0.001).
Among
for
mean
prealbumin
(PAB)/C-reactive
protein
(CRP)
ratio
had
highest
diagnostic
accuracy
(area
under
curve
[AUC]
0.928,
95%
confidence
interval
[95%
CI]
0.892-0.946),
surpassing
Cr/BUN
(AUC
0.740,
CI
0.663-0.819)
transferrin
0.653,
0.574-0.733).
Independent
include
female
advanced
PN,
MV,
lower
BMI,
elevated
BUN
Cr
levels.
may
potentially
delay
onset,
PAB/CRP
be
an
effective
marker
this
condition.
Язык: Английский
Risk factors and predictive modeling in a US population with sarcopenia: a propensity score cohort study
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 26, 2025
Sarcopenia,
characterized
by
loss
of
muscle
mass
and
strength,
particularly
affects
older
adults
is
linked
to
increased
morbidity
mortality.
The
study
aimed
investigate
the
relationship
between
biomarkers,
including
hemoglobin
(Hb),
lactate
dehydrogenase
(LDH),
Systemic
Immune-Inflammation
Index
(SII),
sarcopenia
in
US
population.
Utilizing
NHANES
data
from
2003
2018,
analyzed
5,615
participants,
categorizing
them
based
on
quartiles
Hb,
SII,
LDH
levels.
It
employed
logistic
regression
models
assess
these
biomarkers
risk,
adjusting
for
various
confounders.
High
levels
LDH,
Hb
SII
were
significantly
associated
with
sarcopenia,
higher
risk
highest
quartile.
AUC
all
indicators
predicting
was
0.925
(sensitivity
0.925;
specificity
0.743).
concludes
that
elevated
are
significant
emphasizing
role
inflammation
its
development
potential
markers
early
detection
intervention.
Язык: Английский
Impact of Glucose Profile, Fasting Insulin, and Renal Function on Sarcopenia in Elderly at Single Centered Nursing Home: A Cross-Sectional Structural Equation Model Analysis
Journal of Multidisciplinary Healthcare,
Год журнала:
2025,
Номер
Volume 18, С. 1393 - 1404
Опубликована: Март 1, 2025
Background:
Sarcopenia,
characterized
by
a
progressive
decline
in
muscle
mass
and
strength,
poses
significant
public
health
challenges
for
the
elderly,
impacting
physical
performance
quality
of
life.
This
study
aims
to
investigate
associations
between
glucose
profile,
fasting
insulin,
renal
function,
strength
among
elderly
residents
single-centered
nursing
home
Indonesia,
identifying
potential
biomarkers
sarcopenia.
Methods:
A
cross-sectional
analysis
was
conducted
on
31
Santa
Anna
Nursing
Home,
with
measured
using
handgrip
dynamometry
biochemical
parameters
evaluated
through
standardized
laboratory
methods.
Results:
Structural
Equation
Modeling-Partial
Least
Squares
(SEM-PLS)
revealed
strong
negative
correlations
profile
(β
=
−
0.683,
p
<
0.01)
insulin
0.208,
0.05)
while
function
showed
moderate
positive
relationship
0.295,
0.05).
Conclusion:
These
findings
highlight
as
critical
predictors
sarcopenia,
offering
pathways
early
detection
targeted
interventions.
Future
research
should
explore
longitudinal
assessments
molecular
mechanisms
refine
sarcopenia
prevention
strategies
aging
populations.
Keywords:
biomarkers,
Язык: Английский