Stimulus-Responsive Targeted Lutein Nanoparticles for the Alleviation of Blue Light-Induced Retinal Degeneration DOI

Kangjing Liu,

Yuan Shen, Shiguo Chen

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Май 12, 2025

Growing concern about the prolonged exposure to blue light on eye health has driven interest in bioactive substances that can help protect eyes. In this study, a type of mitochondrion targeted lutein nanoparticles with potential hydrogen (pH) and reactive oxygen species (ROS)-responsive capabilities was designed prepared for retinal degeneration caused by light. Lutein were initially using self-assembly method based (3-carboxypentyl) (triphenyl) phosphonium modified casein-mannose (CAS-Man) conjugates. Subsequently, 3-aminobenzeneboronic acid sodium alginate surrounded surface generate hydrophilic corona. The exhibited pH- ROS-responsive release properties showed good mitochondrial ability after 4 h incubation, Pearson's correlation coefficient 0.88. Visual electrophysiology results indicated alleviated damage improving dark adaptation, preserving vascular microcirculation, enhancing optic nerve conduction function. Fluorescein fundus angiography significantly decreased vessel percentage area 6.93 ± 0.32%, average length 0.59-fold, number junctions 0.88-fold exposure. effectively protected mice from light-induced reducing ROS production retina 1.44-fold inhibiting cellular apoptosis 2.29-fold. These findings suggested pH provided strategy mitigating degeneration.

Язык: Английский

Stimulus-Responsive Targeted Lutein Nanoparticles for the Alleviation of Blue Light-Induced Retinal Degeneration DOI

Kangjing Liu,

Yuan Shen, Shiguo Chen

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Май 12, 2025

Growing concern about the prolonged exposure to blue light on eye health has driven interest in bioactive substances that can help protect eyes. In this study, a type of mitochondrion targeted lutein nanoparticles with potential hydrogen (pH) and reactive oxygen species (ROS)-responsive capabilities was designed prepared for retinal degeneration caused by light. Lutein were initially using self-assembly method based (3-carboxypentyl) (triphenyl) phosphonium modified casein-mannose (CAS-Man) conjugates. Subsequently, 3-aminobenzeneboronic acid sodium alginate surrounded surface generate hydrophilic corona. The exhibited pH- ROS-responsive release properties showed good mitochondrial ability after 4 h incubation, Pearson's correlation coefficient 0.88. Visual electrophysiology results indicated alleviated damage improving dark adaptation, preserving vascular microcirculation, enhancing optic nerve conduction function. Fluorescein fundus angiography significantly decreased vessel percentage area 6.93 ± 0.32%, average length 0.59-fold, number junctions 0.88-fold exposure. effectively protected mice from light-induced reducing ROS production retina 1.44-fold inhibiting cellular apoptosis 2.29-fold. These findings suggested pH provided strategy mitigating degeneration.

Язык: Английский

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