The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANES DOI Creative Commons

Qiaoli Ma,

Zhen Zou, Yanpeng Liu

и другие.

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Апрель 15, 2025

Objective This study investigates the correlation between Life’s Essential 8 (LE8), a cardiovascular health (CVH) metric, and frailty in middle-aged elderly individuals United States, also examining how depression mediates this relationship. Methods Participants from NHANES 2005-2018 were analyzed for correlations LE8 frailty, along with combined effects of using multiple logistic regression. Dose-response relationships assessed restricted cubic splines (RCS), mediation analysis explored depression’s role. Sensitivity subgroup analyses conducted result stability. Results The included 8,982 participants, 3,103 events. A higher score was significantly associated reduced risk adjusted odds ratios medium high CVH groups at 0.49 (95% CI: 0.40-0.58, p < 0.001) 0.21 0.13-0.33, 0.001), respectively. RCS model showed negative dose-response No significant association found depressed population, where mediated 32.13% Conclusion Maintaining good health, as measured by LE8, is key to reducing individuals. underscores importance assessments targeted programs improve quality life.

Язык: Английский

A two-year longitudinal study of the impact of cognitive status and depression on frailty status in older adults following hip fracture DOI

Yu-Hua Hsu,

Jersey Liang,

Ming‐Yueh Tseng

и другие.

Geriatric Nursing, Год журнала: 2025, Номер 62, С. 12 - 18

Опубликована: Фев. 5, 2025

Язык: Английский

Процитировано

0
The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANES DOI Creative Commons

Qiaoli Ma,

Zhen Zou, Yanpeng Liu

и другие.

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Апрель 15, 2025

Objective This study investigates the correlation between Life’s Essential 8 (LE8), a cardiovascular health (CVH) metric, and frailty in middle-aged elderly individuals United States, also examining how depression mediates this relationship. Methods Participants from NHANES 2005-2018 were analyzed for correlations LE8 frailty, along with combined effects of using multiple logistic regression. Dose-response relationships assessed restricted cubic splines (RCS), mediation analysis explored depression’s role. Sensitivity subgroup analyses conducted result stability. Results The included 8,982 participants, 3,103 events. A higher score was significantly associated reduced risk adjusted odds ratios medium high CVH groups at 0.49 (95% CI: 0.40-0.58, p < 0.001) 0.21 0.13-0.33, 0.001), respectively. RCS model showed negative dose-response No significant association found depressed population, where mediated 32.13% Conclusion Maintaining good health, as measured by LE8, is key to reducing individuals. underscores importance assessments targeted programs improve quality life.

Язык: Английский

Процитировано

0