From Cell Architecture to Mitochondrial Signaling: Role of Intermediate Filaments in Health, Aging, and Disease
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1100 - 1100
Опубликована: Янв. 27, 2025
The
coordination
of
cytoskeletal
proteins
shapes
cell
architectures
and
functions.
Age-related
changes
in
cellular
mechanical
properties
have
been
linked
to
decreased
tissue
dysfunction.
Studies
also
found
a
relationship
between
mitochondrial
function
the
cytoskeleton.
Cytoskeleton
inhibitors
impact
quality
function,
including
motility
morphology,
membrane
potential,
respiration.
regulatory
cytoskeleton
on
functions
are
involved
pathogenesis
several
diseases.
Disassembly
axon’s
release
neurofilament
fragments
documented
during
neurodegeneration.
However,
these
can
be
related
impairments,
spanning
from
reduced
altered
bioenergetics.
Herein,
we
discuss
recent
research
highlighting
some
pathophysiological
roles
disassembly
aging,
neurodegeneration,
neuromuscular
diseases,
with
focus
studies
that
explored
intermediate
filaments
signaling
as
relevant
contributors
health
disease.
Язык: Английский
Biology of sex differences in frailty and aging: Where are we?
Experimental Gerontology,
Год журнала:
2025,
Номер
unknown, С. 112711 - 112711
Опубликована: Фев. 1, 2025
Язык: Английский
Clinical presentations and outcomes of respiratory tract infections in an Australian cohort of centenarians
Internal Medicine Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Abstract
Centenarians
are
a
rapidly
growing
patient
population.
Little
is
known
about
their
clinical
responses
to
respiratory
tract
infections.
This
study
examines
cohort
of
centenarians
admitted
tertiary
centre
with
multiplex
polymerase
chain
reaction‐confirmed
infections
characterise
characteristics
and
management
outcomes
better.
Despite
multiple
comorbidities
frailty,
the
overall
mortality
rate
appeared
favourable.
Язык: Английский
1H-NMR-based metabolomics identifies disrupted betaine metabolism as distinct serum signature of pre-frailty
npj Aging,
Год журнала:
2025,
Номер
11(1)
Опубликована: Апрель 12, 2025
Increasing
evidence
suggests
that
frailty
results
from
a
complex
age-associated
metabolic
decline.
Here,
we
investigated
the
serum
metabolomic
profile
of
well-characterized
cohort
elderly
subjects
encompassing
whole
fit-to-frail
continuum.
Enrichment
analyses
revealed
dysregulation
amino
acids
and
energy
metabolism
in
both
pre-frail
frail
participants.
Remarkably,
upregulated
betaine
levels
emerged
as
specific
biochemical
signature
females,
holding
promise
for
development
novel
targeted
interventions.
Язык: Английский
Sex differences in brain iron deposition and microglial ferritin in Alzheimer's disease
Science Progress,
Год журнала:
2025,
Номер
108(2)
Опубликована: Апрель 1, 2025
Objective
Iron
is
the
most
abundant
metal
in
human
brain,
and
plays
a
crucial
role
many
biological
processes.
However,
disruptions
brain
iron
metabolism
can
lead
to
buildup,
which
occurs
with
aging
linked
several
disorders,
including
Alzheimer's
disease.
Microglia,
brain's
resident
immune
cells,
have
highest
capacity
store
iron,
stored
intracellularly
within
ferritin
complexes.
Importantly,
women
are
at
higher
risk
of
developing
disease
experience
faster
progression
compared
men.
Methods
We
used
postmortem
samples
from
patients
small
vessel
both
sexes
for
immunohistochemical
studies.
Samples
were
stained
Prussian
blue
method
visualize
deposits
antibodies
against
microglia
marker
Iba1
light
chain.
Results
Our
study
reveals
that
number
levels
chain
positively
correlated
men
disease,
but
negatively
women.
There
no
correlation
between
deposition
sexes.
Conclusions
These
results
could
inform
more
tailored
approaches
treatment
management
based
on
sex-specific
differences
microglial
storage
capacity.
Язык: Английский