Severity of bronchopulmonary dysplasia and characteristics of neuro-motor development prior to acquisition of independent walking in very preterm and/or very low-birth-weight infants: A retrospective cohort study in a children's medical centre in Japan
Early Human Development,
Год журнала:
2025,
Номер
203, С. 106225 - 106225
Опубликована: Фев. 20, 2025
Язык: Английский
Prenatal inflammation exacerbates hyperoxia-induced neonatal brain injury
Journal of Neuroinflammation,
Год журнала:
2025,
Номер
22(1)
Опубликована: Фев. 28, 2025
Abstract
Background
Premature
born
infants
are
at
high
risk
to
develop
white
matter
injury
(WMI).
Hyperoxia
and
perinatal
inflammation
main
factors
for
preterm
birth
associated
brain
injury.
To
date
the
majority
of
experimental
studies
have
focused
on
isolated
insults.
However,
clinically,
WMI
is
a
multifactorial
disorder
caused
by
variety
triggers.
establish
clinically
relevant
rodent
model
WMI,
we
combined
prenatal
with
postnatal
hyperoxia
investigate
individual,
additive
or
synergistic
effects
inflammatory
processes,
myelination
grey
development.
Methods
At
embryonic
day
20,
pregnant
Wistar
rat
dams
received
either
single
intraperitoneal
injection
100
µg/
kg
lipopolysaccharide
(LPS)
sodium
chloride.
Offspring
were
exposed
(80%
O
2
)
normoxia
(21%
from
3
5.
Animals
sacrificed
immediately
after
6
days
later,
corresponding
term-equivalent
age.
White
development
neuroinflammatory
responses
investigated
cellular
molecular
levels
applying
immunohistochemistry,
western
blotting,
real
time
PCR
in
tissues
multiplex
protein
expression
analysis
serum
samples.
Results
Prenatal
resulted
reduced
body
weight
length
offspring,
accompanied
increased
leptin
term
equivalent
The
altered
parameters,
like
weight,
decreased
volume,
thinning
deep
cortical
layers
hypomyelination.
As
potential
underlying
mechanisms,
identified
severe
deficits
an
microglia
activation
elevated
cytokine
tissues,
while
peripheral
reduced.
Interestingly,
size
mainly
mediated
LPS,
independent
hyperoxia,
oligodendrocyte
degeneration
was
induced
inflammation.
pathological
changes,
including
size,
deficits,
expression,
detected.
Conclusion
results
aggravated
compared
insults,
making
it
ideal
improve
our
understanding
complex
pathophysiology
evaluate
urgently
needed
therapies.
Язык: Английский
Beta-3 Adrenoceptor Agonism Protects the Enteric Nervous Tissue Against Hyperoxia-Induced Damage
Cells,
Год журнала:
2025,
Номер
14(7), С. 475 - 475
Опубликована: Март 21, 2025
The
beta-3
adrenergic
receptor
(β3-AR),
whose
expression
is
modulated
by
oxygen
levels,
was
found
to
play
a
key
role
in
organ
maturation,
and
its
agonism
reported
mitigate
hyperoxia-induced
large
bowel
damage
preventing
hypoplasia,
preserving
epithelial
integrity,
vascularization,
the
neurochemical
coding
colonic
myenteric
plexus.
This
study
explored
effects
of
β3-AR
hyperoxia-related
alterations
on
ileal
enteric
nervous
system
(ENS).
Sprague–Dawley
rat
pups
were
reared
under
normoxia
or
hyperoxia
(85%)
during
first
two
weeks
after
birth
treated
not
with
agonist
BRL37344
at
1,
3,
6
mg/kg.
Hyperoxia
caused
an
imbalance
inhibitory
nitrergic
excitatory
cholinergic
neurons
both
submucosal
plexuses
decreased
amounts
plexus
that
S100β+
GFAP+
glial
cells
Administration
3
mg/kg
preserved
neuronal
chemical
partially
prevented
loss
cells,
while
it
did
counteract
loss.
Our
findings
indicate
potential
as
new
therapeutic
strategy
for
ENS
alterations.
Язык: Английский
Caffeine: The Story beyond Oxygen-Induced Lung and Brain Injury in Neonatal Animal Models—A Narrative Review
Antioxidants,
Год журнала:
2024,
Номер
13(9), С. 1076 - 1076
Опубликована: Сен. 3, 2024
Caffeine
is
one
of
the
most
commonly
used
drugs
in
intensive
care
to
stimulate
respiratory
control
mechanisms
very
preterm
infants.
Respiratory
instability,
due
degree
immaturity
at
birth,
results
apnea
prematurity
(AOP),
hyperoxic,
hypoxic,
and
intermittent
hypoxic
episodes.
Oxidative
stress
cannot
be
avoided
as
a
direct
reaction
leads
neurological
developmental
deficits
even
higher
prevalence
diseases
further
development
premature
Due
proven
antioxidant
effect
caffeine
early
use,
largely
protective
effects
on
clinical
outcomes
can
observed.
This
also
impressively
observed
experimental
studies
application
oxidative
stress-adapted
rodent
models
damage
developing
brain
lungs.
However,
shows
undesirable
outside
these
oxygen
toxicity
injury
models.
review
hypoxic/hypoxic-ischemic,
models,
but
negative
organism
when
administered
without
exogenous
stress.
The
narrative
analysis
benefits
cerebral
pulmonary
infant
supports
use
should
given
critical
consideration
considering
treatment
beyond
recommended
corrected
gestational
age.
Язык: Английский
Unveiling the Emerging Role of Extracellular Vesicle–Inflammasomes in Hyperoxia-Induced Neonatal Lung and Brain Injury
Cells,
Год журнала:
2024,
Номер
13(24), С. 2094 - 2094
Опубликована: Дек. 18, 2024
Extremely
premature
infants
are
at
significant
risk
for
developing
bronchopulmonary
dysplasia
(BPD)
and
neurodevelopmental
impairment
(NDI).
Although
BPD
is
a
predictor
of
poor
outcomes,
it
currently
unknown
how
contributes
to
brain
injury
long-term
NDI
in
pre-term
infants.
Extracellular
vesicles
(EVs)
small,
membrane-bound
structures
released
from
cells
into
the
surrounding
environment.
EVs
involved
inter-organ
communication
diverse
pathological
processes.
Inflammasomes
large,
multiprotein
complexes
that
part
innate
immune
system
responsible
triggering
inflammatory
responses
cell
death.
Apoptosis-associated
speck-like
protein
containing
caspase
recruitment
domain
(ASC)
pivotal
inflammasome
assembly
activating
caspase-1.
Activated
caspase-1
cleaves
gasdermin
D
(GSDMD)
release
30
kD
N-terminal
can
form
membrane
pores,
leading
lytic
death,
also
known
as
pyroptosis.
cleave
pro-IL-1β
pro-IL-18
their
active
forms,
which
be
rapidly
through
GSDMD
pores
induce
inflammation.
Recent
evidence
has
emerged
activation
inflammasomes
associated
with
neonatal
lung
injury,
inhibition
reduces
hyperoxia-induced
injury.
Additionally,
multiple
studies
have
demonstrated
hyperoxia
stimulates
lung-derived
contain
cargos.
Adoptive
transfer
these
circulation
normal
mice
rats
induces
This
review
focuses
on
EV–inflammasomes’
roles
mediating
lung-to-brain
crosstalk
via
EV-dependent
EV-independent
mechanisms
critical
BPD,
pathogenesis.
EV–inflammasomes
will
discussed
potential
therapeutic
targets
Язык: Английский
MicroRNA Expression Profiles in the Neonatal Rat Hippocampus Exposed to Normobaric Hyperoxia
Open Journal of Pediatrics,
Год журнала:
2024,
Номер
14(06), С. 1038 - 1049
Опубликована: Янв. 1, 2024
Язык: Английский
β3‐Adrenoceptor Agonism to Mimic the Biological Effects of Intrauterine Hypoxia: Taking Great Strides Toward a Pharmacological Artificial Placenta
Medicinal Research Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
ABSTRACT
At
different
stages
of
life,
from
embryonic
to
postnatal,
varying
oxygen
concentrations
modulate
cellular
gene
expression
by
enhancing
or
repressing
hypoxia‐inducible
transcription
factors.
During
embryonic/fetal
these
genes
encode
proteins
involved
in
adapting
a
low‐oxygen
environment,
including
the
induction
specific
enzymes
related
glycolytic
metabolism,
erythropoiesis,
angiogenesis,
and
vasculogenesis.
However,
fluctuate
during
intrauterine
enabling
tissue‐specific
differentiation
processes.
Fetal
well‐being
is
thus
closely
linked
physiological
benefits
dynamically
hypoxic
environment.
Premature
birth
entails
precocious
exposure
immature
fetus
more
oxygen‐rich
environment
compared
womb.
As
result,
preterm
newborns
face
condition
relative
hyperoxia,
which
alters
postnatal
development
organs
contributes
prematurity‐related
diseases.
until
recently,
molecular
mechanism
high
tension
normal
fetal
remained
unclear.
In
this
review,
we
discuss
research
trajectory
followed
our
group,
suggests
that
early
relatively
hyperoxic
may
impair
neonates
due
reduced
β
3
‐adrenoceptor.
Additionally,
explore
how
impairments
could
be
prevented
through
pharmacological
stimulation
remaining
β3‐adrenoceptors.
Recent
preclinical
studies
demonstrate
‐adrenoceptor
can
decouple
hyperoxia
its
harmful
effects,
offering
glimpse
possibility
recreating
conditions
typical
even
after
premature
birth.
Язык: Английский