Research Progress of Flavonoids in Spinal Cord Injury: Therapeutic Mechanisms and Drug Delivery Strategies DOI
Shizhe Li, Shutao Gao, Yukun Hu

и другие.

Phytotherapy Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Spinal cord injury (SCI) is a serious neurological disease with an extremely high disability rate. Most patients show loss of motor and sensory functions below the level injury. Current treatment protocols are based on early surgical decompression pharmacotherapy. However, efficacy these interventions suboptimal. Due to its complex pathophysiological mechanisms difficulty central nervous system (CNS) regeneration, exploring effective therapeutic remains daunting. Flavonoids secondary metabolites unique plants that have attracted attention in recent years for their potential now commonly used inflammation, tumors, other diseases. For SCI, related studies still exploring; some compounds, such as quercetin, fisetin, hesperetin, shown good anti-inflammatory anti-apoptotic properties, which help restore function injured spinal cord. flavonoids exhibit certain disadvantages, including poor solubility, low bioavailability, inability achieve long-term controlled release. Some proposed drug delivery strategies-including nanoparticles, hydrogels, collagen scaffolds-to enhance efficacy. In this paper, we summarize strategies SCI by searching relevant literature propose future research directions provide new ideas multimodal SCI.

Язык: Английский

Melatonin attenuates spinal cord injury by regulating ferroptosis through the Nrf2/HO-1/GPX4 pathway DOI Creative Commons

Zhengxi Yu,

Dingwei Wu, Tengbin Shi

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Abstract Spinal cord injury (SCI) is one of the most devastating and catastrophic types injury, with high rates mortality disability. Ferroptosis has become target many major incurable human diseases. By inhibiting ferroptosis, melatonin (MT) can reduce damage in various organs, but protective effect MT on SCI not been reported yet. The modified Ellen's method was used to establish an rat model. spinal neurons recovery motor function were observed. In vitro experiments, oxygen-glucose deprivation/reoxygenation (OGD/R) model established by using mouse hippocampal neuron (HT22) cells simulate ischemia-reperfusion injury. A ferroptosis directly induced Erastin also used. nuclear factor erythroid 2-related 2 (Nrf2) inhibitor ML 385 further detect mechanism through which inhibits protects neuronal cells. Our study demonstrates that rats, promote behavior injured tissue after SCI. Under electron microscope, inhibited rescued damaged mitochondria, partially restored mitochondrial structure. ML385, Nrf2 inhibitor, reversed effects MT. Overall, may alleviate early activating Nrf2/heme oxygenase-1(HO-1)/glutathione peroxidase 4 (GPX 4) pathway.

Язык: Английский

Процитировано

0
Research Progress of Flavonoids in Spinal Cord Injury: Therapeutic Mechanisms and Drug Delivery Strategies DOI
Shizhe Li, Shutao Gao, Yukun Hu

и другие.

Phytotherapy Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Spinal cord injury (SCI) is a serious neurological disease with an extremely high disability rate. Most patients show loss of motor and sensory functions below the level injury. Current treatment protocols are based on early surgical decompression pharmacotherapy. However, efficacy these interventions suboptimal. Due to its complex pathophysiological mechanisms difficulty central nervous system (CNS) regeneration, exploring effective therapeutic remains daunting. Flavonoids secondary metabolites unique plants that have attracted attention in recent years for their potential now commonly used inflammation, tumors, other diseases. For SCI, related studies still exploring; some compounds, such as quercetin, fisetin, hesperetin, shown good anti-inflammatory anti-apoptotic properties, which help restore function injured spinal cord. flavonoids exhibit certain disadvantages, including poor solubility, low bioavailability, inability achieve long-term controlled release. Some proposed drug delivery strategies-including nanoparticles, hydrogels, collagen scaffolds-to enhance efficacy. In this paper, we summarize strategies SCI by searching relevant literature propose future research directions provide new ideas multimodal SCI.

Язык: Английский

Процитировано

0