Effects of the Maximum Recommended Levels of Fumonisins in the EU on Oxylipin Profiles in the Liver and Brain of Chickens DOI Creative Commons
Philippe Guerre,

Elodie Lassallette,

Amélie Guerre

и другие.

Antioxidants, Год журнала: 2024, Номер 14(1), С. 19 - 19

Опубликована: Дек. 27, 2024

This study aimed to assess the effects of a diet containing 20.8 mg FB1 + FB2/kg over four and nine days on oxylipin (OL) profiles in liver brain chickens. A total 96 OLs, derived from seven polyunsaturated fatty acids (PUFAs) via cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 (P450), non-enzymatic pathways, were measured using HPLC-MS/MS. In liver, significant increase epoxide P450-derived OLs was detected by day 4, with smaller but notable increases COX- LOX-derived 9. These alterations independent whether parent PUFA ω6 or ω3. However, 18-carbon (C18) PUFAs, such as linoleic acid alpha-linolenic acid, showed greater compared those C20 C22 PUFAs. The diol/epoxide ratios decreased at days, suggesting that fumonisins did not induce an inflammatory response. brain, most discriminative ω3-PUFAs, including docosahexaenoic docosapentaenoic LOX pathway. By several arachidonic spanning all enzymatic became discriminative. general, 4 then returned initial levels. Taken together, these results show strong are both specific distinct.

Язык: Английский

Effects of the Maximum Recommended Levels of Fumonisins in the EU on Oxylipin Profiles in the Liver and Brain of Chickens DOI Creative Commons
Philippe Guerre,

Elodie Lassallette,

Amélie Guerre

и другие.

Antioxidants, Год журнала: 2024, Номер 14(1), С. 19 - 19

Опубликована: Дек. 27, 2024

This study aimed to assess the effects of a diet containing 20.8 mg FB1 + FB2/kg over four and nine days on oxylipin (OL) profiles in liver brain chickens. A total 96 OLs, derived from seven polyunsaturated fatty acids (PUFAs) via cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 (P450), non-enzymatic pathways, were measured using HPLC-MS/MS. In liver, significant increase epoxide P450-derived OLs was detected by day 4, with smaller but notable increases COX- LOX-derived 9. These alterations independent whether parent PUFA ω6 or ω3. However, 18-carbon (C18) PUFAs, such as linoleic acid alpha-linolenic acid, showed greater compared those C20 C22 PUFAs. The diol/epoxide ratios decreased at days, suggesting that fumonisins did not induce an inflammatory response. brain, most discriminative ω3-PUFAs, including docosahexaenoic docosapentaenoic LOX pathway. By several arachidonic spanning all enzymatic became discriminative. general, 4 then returned initial levels. Taken together, these results show strong are both specific distinct.

Язык: Английский

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