Cathepsin B induces kidney diseases through different types of programmed cell death

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 10, 2025

Cathepsin B (CTSB), a key cysteine protease, plays essential roles in physiological and pathological processes. As research progresses, interest how CTSB triggers different types of programmed cell death (PCD) to induce the onset development diseases is increasing. Several recent studies suggest that PCD mediated by play kidney diseases. In this review, we outline fundamental mechanisms which several discuss function various segments kidney. Moreover, explore possibilities prospects using as therapeutic target for

Язык: Английский

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Immunomodulatory mechanisms of low molecular weight peptides from Pinctada martensii: A network pharmacology and in vivo study on gut microbiota and immune function

Journal of Functional Foods, Год журнала: 2025, Номер 129, С. 106874 - 106874

Опубликована: Май 6, 2025

Язык: Английский

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A yak bone collagen‐derived antioxidant peptide with excellent stability alleviates UVA‐induced photoaging by activating the Keap1/Nrf2 signaling pathway

Journal of the Science of Food and Agriculture, Год журнала: 2025, Номер unknown

Опубликована: Май 9, 2025

Abstract Background Prolonged exposure to ultraviolet A (UVA) rays can trigger oxidative stress, leading skin photoaging. Our team previously identified four antioxidant peptides derived from yak bone collagen through bioinformatics prediction. The objective of this study was screen out one most promising application peptide molecular docking, in vitro activity verification and stability assessment, elucidate its mechanism action. Results results docking studies suggested that GGGPPGPM (P1) could effectively bind the key protein Keap1 signaling pathway. screening indicated P1 exhibited highest 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging (83.42 ± 3.07%) Fe 2+ chelating ability (69.25 6.10%) at a concentration 1 mg mL −1 . Additionally, with exception few conditions, retained more than 90% DPPH across wide range temperature, pH, metal ions typical processing aids. Cellular significantly reduced production reactive oxygen species malonaldehyde UVA‐damaged cells, elevated levels superoxide dismutase catalase. It found Keap1/Nrf2 pathway photoaging cells modulated under intervention, increasing expression NAD(P)H dehydrogenase quinone heme oxygenase‐1. In addition, notably enhanced mRNA level tissue inhibitor protease I decreased matrix metalloproteinase‐1. Conclusion These findings demonstrated presents therapeutic candidate for mitigating An animal model might be employed further examination corroborate these findings. © 2025 Society Chemical Industry.

Язык: Английский

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The use of β-glucans and other polysaccharides from edible fungi for improving obesity: A review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 318, С. 144898 - 144898

Опубликована: Июнь 3, 2025

Язык: Английский

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Didymin Ameliorates Dextran Sulfate Sodium (DSS)-Induced Ulcerative Colitis by Regulating Gut Microbiota and Amino Acid Metabolism in Mice

Metabolites, Год журнала: 2024, Номер 14(10), С. 547 - 547

Опубликована: Окт. 14, 2024

Didymin is a dietary flavonoid derived from citrus fruits and has been shown to have extensive biological functions, especially anti-inflammatory effects, but its mechanism unclear. The purpose of this study was investigate the potential didymin that alleviates ulcerative colitis.

Язык: Английский

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