A standardized chamuangone enriched extract from Garcinia cowa Roxb. leaves shows acute and sub-acute safety

Journal of Ethnopharmacology, Год журнала: 2024, Номер 335, С. 118625 - 118625

Опубликована: Июль 23, 2024

Язык: Английский

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Prediction of ADMET profile and anti-inflammatory potential of chamuangone

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 23, 2025

Chamuangone, a compound extracted from the leaves of Garcinia cowa, exhibits various biological activities. Yet, its absorption, distribution, metabolism, excretion, and toxicity (ADMET) profile as well anti-inflammatory effects in macrophages remain unexplored. In this study, we employed computational tool to predict ADMET chamuangone performed molecular docking simulations assess interactions with key proteins involved inflammatory pathways. Additionally, vitro experiments using lipopolysaccharide (LPS)-induced RAW264.7 were evaluate effects. The present findings suggest that has favorable properties, interacts strongly major inflammation, activity LPS-induced macrophages, making it promising agent.

Язык: Английский

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A standardized chamuangone enriched extract shows anticancer efficacy in allograft models of metastatic breast cancer

Journal of Functional Foods, Год журнала: 2025, Номер 127, С. 106730 - 106730

Опубликована: Март 15, 2025

Язык: Английский

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Cytotoxic prenylated xanthone derivatives from the twigs of Garcinia cowa

Natural Product Research, Год журнала: 2024, Номер unknown, С. 1 - 9

Опубликована: Окт. 25, 2024

A new prenylated xanthone, kaennacowanol D (

Язык: Английский

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