Smoking as a causative factor in chronic kidney disease: a two-sample Mendelian randomization study

Renal Failure, Год журнала: 2025, Номер 47(1)

Опубликована: Янв. 21, 2025

Smoking is widely acknowledged for its harmful effects on multiple organs. However, specific causal relationship with chronic kidney disease (CKD) remains uncertain. This study applied bivariate analysis and two-sample Mendelian randomization (MR) methods to examine the association between various smoking behaviors – initiation, cessation, age at cigarettes smoked per day, lifetime CKD, using genome-wide data. The inverse variance weighted (IVW) method was primary analytical tool, supported by sensitivity analyses, pleiotropy assessments, mediation analyses. External validation conducted independent datasets. results revealed positive associations CKD initiation (Pivw = 1.8 × 10−2, OR 1.192), earlier 2.3 10−3, 1.481), day 8.8 1.216), 10−7, 2.445). In contrast, cessation demonstrated a protective effect against 4.0 10−12, 0.791). aligned findings, absence of significant heterogeneity confirmed robustness MR analysis. Additionally, mediated factors such as body mass index, cardiovascular disease, hypertension, type 2 diabetes. These findings identify contributing factor suggest that reducing prevalence could significantly lower incidence in population.

Язык: Английский

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Emerging Roles of Long Non‐Coding RNAs in Cardiovascular Diseases

Journal of Cellular and Molecular Medicine, Год журнала: 2025, Номер 29(5)

Опубликована: Март 1, 2025

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Over past decade, studies have demonstrated that circulating long non-coding RNAs (lncRNAs)-recognised for their stability ease detection-serve as crucial regulators potential biomarkers in multiple diseases. LncRNAs regulate key processes, including endothelial function, vascular remodelling, myocardial hypertrophy, all which influence CVD progression. Additionally, lncRNAs display cell-, tissue-, disease-specific expression patterns, making them ideal therapeutic targets or tools. This review presents a comprehensive overview current understanding CVDs, examining mechanisms action recent research advances. It also addresses use diagnostic prognostic markers, well applications RNA therapeutics novel treatment strategies.

Язык: Английский

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Risk of and Factors Influencing the Progression from Acute to Recurrent Acute to Chronic Pancreatitis

Pancreatology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Atractylenolide I Inhibits Nicotine-Induced Macrophage Pyroptosis and Alleviates Atherogenesis by Suppressing the TLR4/ROS/TXNIP/NLRP3 Pathway

Metabolites, Год журнала: 2025, Номер 15(5), С. 329 - 329

Опубликована: Май 15, 2025

Background/Objectives: Studies have shown that Atractylenolide I (AT-I) can exert anti-inflammatory and anti-oxidative effects, protecting against the development of various kinds cardiovascular diseases. However, whether AT-I prevents nicotine-induced atherogenesis is unknown. This study was designed to explore effects on macrophage pyroptosis progression atherosclerosis. Methods: RT-qPCR Western blot were used detect mRNA protein levels TXNIP pyroptosis-related factors in THP-1-derived macrophages. ELISA secretion pro-inflammatory cytokines. Hoechst/PI double-staining assay assess plasma membrane integrity. The ROS kit, LDH release caspase-1 activity kit production, release, activity. Oil Red O, HE, Masson staining evaluate lipid accumulation, lesion size, plaque stability HFD-fed apoE-/- mice. Results: treatment significantly decreased expression, disrupted integrity, down-regulated cytokines secretion, thereby inhibiting In addition, production expression TLR4 TXNIP. Lentivirus overexpression or TXNIP, pre-treatment with agonist, mainly reversed anti-pyroptotic nicotine-treated Additionally, administering mice markedly up-regulation proteins aortas. Enzymatic methods suggested improved dyslipidemia inflammation vivo. showed alleviated increased stability. Conclusions: Taken together, be regarded as a potential phytomedicine protects atherosclerosis triggered by nicotine.

Язык: Английский

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Comprehensive profile of circRNAs in formaldehyde induced heart development

Food and Chemical Toxicology, Год журнала: 2022, Номер 162, С. 112899 - 112899

Опубликована: Фев. 26, 2022

Язык: Английский

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