The close association of micronutrients with COVID-19 DOI Creative Commons
Aimin Zhang, Yue Yin,

Jiashu Tian

и другие.

Heliyon, Год журнала: 2024, Номер 10(7), С. e28629 - e28629

Опубликована: Март 27, 2024

ObjectivesThe present study was conducted to explore the performance of micronutrients in prediction and prevention coronavirus disease 2019 (COVID-19).MethodsThis is an observational case-control study. 149 normal controls (NCs) 214 COVID-19 patients were included this Fat-soluble water-soluble vitamins determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, inorganic elements detected inductively coupled plasma-mass (ICP-MS) analysis. A logistic regression model based on six constructed using DxAI platform.ResultsMany dysregulated compared control (NC). 25-Hydroxyvitamin D3 [25(OH)D3], magnesium (Mg), copper (Cu), calcium (Ca) vitamin B6 (pyridoxic acid, PA) significantly independent risk factors for COVID-19. The consisted 25(OH)D3, Mg, Cu, Ca, B5 (VB5) PA developed, displayed a strong discriminative capability differentiate from NC individuals [area under receiver operating characteristic curve (AUROC) = 0.901]. In addition, had great predictive ability discriminating mild/normal (AUROC 0.883).ConclusionsOur showed that associated with COVID-19, our has potential clinical management will be useful screening high-risk population.

Язык: Английский

The prognostic role of micronutrient status and supplements in COVID-19 outcomes: A systematic review DOI Open Access
Evmorfia Pechlivanidou, Dimitriοs Vlachakis, Konstantinos Tsarouhas

и другие.

Food and Chemical Toxicology, Год журнала: 2022, Номер 162, С. 112901 - 112901

Опубликована: Фев. 25, 2022

Язык: Английский

Процитировано

23

Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review DOI Creative Commons
Anieli Golin, Alexey A. Tinkov, Michael Aschner

и другие.

Journal of Trace Elements in Medicine and Biology, Год журнала: 2022, Номер 75, С. 127099 - 127099

Опубликована: Ноя. 3, 2022

Язык: Английский

Процитировано

23

Metal-coding assisted serological multi-omics profiling deciphers the role of selenium in COVID-19 immunity DOI Creative Commons
Ying Zhou, Shuofeng Yuan, Fan Xiao

и другие.

Chemical Science, Год журнала: 2023, Номер 14(38), С. 10570 - 10579

Опубликована: Янв. 1, 2023

Uncovering how host metal(loid)s mediate the immune response against invading pathogens is critical for better understanding pathogenesis mechanism of infectious disease. Clinical data show that imbalance closely associated with severity and mortality COVID-19. However, it remains elusive metal(loid)s, which are essential elements all forms life multiple diseases if dysregulated, involved in COVID-19 pathophysiology immunopathology. Herein, we built up a metal-coding assisted multiplexed serological metallome immunoproteome profiling system to characterize links immunity. We found distinct features patients compared non-infected control subjects, may serve as biomarker disease diagnosis. Moreover, generated first correlation network between immunity mediators, unbiasedly uncovered strong association selenium interleukin-10 (IL-10). Supplementation cells resulted enhanced IL-10 expression B reduced induction proinflammatory cytokines CD4+ T cells. The selenium-enhanced production was confirmed be attributable activation ERK Akt pathways. further validated our cellular SARS-CoV-2-infected K18-hACE2 mice, supplementation alleviated SARS-CoV-2-induced lung damage characterized by decreased alveolar inflammatory infiltrates through restoration virus-repressed selenoproteins alleviate oxidative stress. Our approach can readily extended other understand defends regulation metallome.

Язык: Английский

Процитировано

11

Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma DOI Creative Commons
Kim Berlo, Weiming Xia,

Florentine Zwillich

и другие.

Scientific Reports, Год журнала: 2022, Номер 12(1)

Опубликована: Янв. 31, 2022

Abstract As the SARS-CoV-2 pandemic persists, methods that can quickly and reliably confirm infection immune status is extremely urgently critically needed. In this contribution we show combining laser induced breakdown spectroscopy (LIBS) with machine learning distinguish plasma of donors who previously tested positive for by RT-PCR from those did not, up to 95% accuracy. The samples were also analyzed LIBS-ICP-MS in tandem mode, implicating a depletion Zn Ba subjects inversely correlate CN lines LIBS spectra.

Язык: Английский

Процитировано

15

Crystal structure, Hirshfeld surface analysis, molecular modeling, electrochemical properties, and potential medicinal activity of a novel binuclear Co(II) complex DOI

Walid M. Elsheemy,

Ayman A. Abdel Aziz, Ramadan M. Ramadan

и другие.

Applied Organometallic Chemistry, Год журнала: 2024, Номер 38(11)

Опубликована: Июль 19, 2024

A quinoxaline‐based ligand, 6,7‐dimethyl‐2,3‐di(2‐pyridyl)quinoxaline (Me 2 dpq), and its unique binuclear Co(II)‐Me dpq complex were prepared analyzed using single crystal X‐ray diffraction several spectroscopy techniques. Hirshfeld surface analyses also used to clarify the Me ligand packing. The crystallized in triclinic P‐1 space group exhibited a distorted trigonal bipyramidal geometry around cobalt(II) ion. Each Co(II) ion coordinated through two N donor centers from pyridyl quinoxaline rings along with terminal Cl bridged atoms. binding properties of CT‐DNA studied by techniques, namely UV–Vis spectroscopy, fluorescence quenching, viscosity measurements, thermal denaturation, gel electrophoresis. interaction tests demonstrated that both parent bind DNA an intercalative way. antioxidant studies novel illustrated significant activity against DPPH • radicals. vitro cytotoxic effect Co(II)‐complex on MCF‐7 Hep‐G2 tumor cell lines was evaluated MTT assay. showed had superior toward tested lines. Molecular docking synthesized compounds employed figure out way they would associate biologically macromolecular target B‐DNA (PDB: 1BNA). Thus, this study is anticipated provide opportunities for successful utilization many medical domains.

Язык: Английский

Процитировано

3

Health Assessment of Natural Selenium-Rich Soil in Yuanzhou District Based on Selenium–Cadmium Principal Factors and the Accumulation of Selenium and Cadmium in the Area Crops DOI Creative Commons
Ning He,

Yu-Ting Su,

Fang Huang

и другие.

Agriculture, Год журнала: 2025, Номер 15(11), С. 1149 - 1149

Опубликована: Май 27, 2025

Selenium (Se) is essential for human health, but it interacts with cadmium (Cd). However, there has been little focus on developing soil health evaluation models based the interaction between Se and heavy metals, or transport of Cd in oilseed rape. Through detection, was found that Yuanzhou District mostly Se-rich (average 0.62 mg kg−1). Correlation analysis showed a positive correlation content (r = 0.62, p < 0.01) organic matter 0.60, 0.01). A score model developed performed well, indicating can be used to estimate relevant scores. Furthermore, natural rice ranges from 0.07 0.28 kg−1, overall enrichment ability rape stronger than rice. According analysis, significantly correlated stems 0.49, 0.37, 0.05). As result, this study suggests using rice/oilseed intercropping farming transfer into reduce

Язык: Английский

Процитировано

0

A negative combined effect of exposure to maternal Mn-Cu-Rb-Fe metal mixtures on gestational anemia, and the mediating role of creatinine in the Guangxi Birth Cohort Study (GBCS): Twelve machine learning algorithms DOI

Yuen Zhong,

Yu Bao,

Hong Cheng

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 300, С. 118418 - 118418

Опубликована: Май 31, 2025

Язык: Английский

Процитировано

0

Trace element homeostasis in the neurological system after SARS-CoV-2 infection: Insight into potential biochemical mechanisms DOI Open Access
Jemmyson Romário de Jesus, Rodrigo Moretto Galazzi, Cícero Alves Lopes Júnior

и другие.

Journal of Trace Elements in Medicine and Biology, Год журнала: 2022, Номер 71, С. 126964 - 126964

Опубликована: Фев. 26, 2022

Язык: Английский

Процитировано

14

Association of trace element status in COVID-19 patients with disease severity DOI Open Access
Tamer Bego, Neven Meseldžić, Besim Prnjavorac

и другие.

Journal of Trace Elements in Medicine and Biology, Год журнала: 2022, Номер 74, С. 127055 - 127055

Опубликована: Авг. 4, 2022

Язык: Английский

Процитировано

11

Iron deficiency and the effectiveness of the BNT162b2 vaccine for SARS-CoV-2 infection: A retrospective, longitudinal analysis of real-world data DOI Creative Commons
Lilac Tene,

Avraham Karasik,

Gabriel Chodick

и другие.

PLoS ONE, Год журнала: 2023, Номер 18(5), С. e0285606 - e0285606

Опубликована: Май 22, 2023

Background Iron plays a key role in human immune responses; however, the influence of iron deficiency on coronavirus disease 2019 (COVID-19) vaccine effectiveness is unclear. Aim To assess BNT162b2 messenger RNA COVID-19 preventing severe acute respiratory syndrome 2 (SARS-CoV-2) infection and COVID-19–related hospitalization death individuals with or without deficiency. Methods This large retrospective, longitudinal cohort study analyzed real-world data from Maccabi Healthcare Services database (covering 25% Israeli residents). Eligible adults (aged ≥ 16 years) received first dose between December 19, 2020, February 28, 2021, followed by second as per approved label. Individuals were excluded if they had SARS-CoV-2 before vaccination, hemoglobinopathy, cancer diagnosis since January been treated immunosuppressants, pregnant at time vaccination. Vaccine was assessed terms incidence rates confirmed real-time polymerase chain reaction assay, relative risks hospitalization, mortality (ferritin <30 ng/mL transferrin saturation <20%). The two-dose protection period Days 7 to 28 after Results Data 184,171 (mean [standard deviation; SD] age 46.2 [19.6] years; 81.2% female) versus 1,072,019 [SD] 46.9 [18.0] 46.2% known analyzed. 91.9% (95% confidence interval [CI] 83.7–96.0%) 92.1% CI 84.2–96.1%) for those ( P = 0.96). Of patients deficiency, hospitalizations occurred 19 100,000 during reference (Days 1–7 dose), period, respectively. Mortality comparable groups: 2.2 (4/181,012) population 1.8 (19/1,055,298) Conclusions suggest that >90% effective 3 weeks irrespective iron-deficiency status. These findings support use populations

Язык: Английский

Процитировано

6