Heliyon,
Год журнала:
2024,
Номер
10(7), С. e28629 - e28629
Опубликована: Март 27, 2024
ObjectivesThe
present
study
was
conducted
to
explore
the
performance
of
micronutrients
in
prediction
and
prevention
coronavirus
disease
2019
(COVID-19).MethodsThis
is
an
observational
case-control
study.
149
normal
controls
(NCs)
214
COVID-19
patients
were
included
this
Fat-soluble
water-soluble
vitamins
determined
by
liquid
chromatography-tandem
mass
spectrometry
(LC-MS/MS)
analysis,
inorganic
elements
detected
inductively
coupled
plasma-mass
(ICP-MS)
analysis.
A
logistic
regression
model
based
on
six
constructed
using
DxAI
platform.ResultsMany
dysregulated
compared
control
(NC).
25-Hydroxyvitamin
D3
[25(OH)D3],
magnesium
(Mg),
copper
(Cu),
calcium
(Ca)
vitamin
B6
(pyridoxic
acid,
PA)
significantly
independent
risk
factors
for
COVID-19.
The
consisted
25(OH)D3,
Mg,
Cu,
Ca,
B5
(VB5)
PA
developed,
displayed
a
strong
discriminative
capability
differentiate
from
NC
individuals
[area
under
receiver
operating
characteristic
curve
(AUROC)
=
0.901].
In
addition,
had
great
predictive
ability
discriminating
mild/normal
(AUROC
0.883).ConclusionsOur
showed
that
associated
with
COVID-19,
our
has
potential
clinical
management
will
be
useful
screening
high-risk
population.
Chemical Science,
Год журнала:
2023,
Номер
14(38), С. 10570 - 10579
Опубликована: Янв. 1, 2023
Uncovering
how
host
metal(loid)s
mediate
the
immune
response
against
invading
pathogens
is
critical
for
better
understanding
pathogenesis
mechanism
of
infectious
disease.
Clinical
data
show
that
imbalance
closely
associated
with
severity
and
mortality
COVID-19.
However,
it
remains
elusive
metal(loid)s,
which
are
essential
elements
all
forms
life
multiple
diseases
if
dysregulated,
involved
in
COVID-19
pathophysiology
immunopathology.
Herein,
we
built
up
a
metal-coding
assisted
multiplexed
serological
metallome
immunoproteome
profiling
system
to
characterize
links
immunity.
We
found
distinct
features
patients
compared
non-infected
control
subjects,
may
serve
as
biomarker
disease
diagnosis.
Moreover,
generated
first
correlation
network
between
immunity
mediators,
unbiasedly
uncovered
strong
association
selenium
interleukin-10
(IL-10).
Supplementation
cells
resulted
enhanced
IL-10
expression
B
reduced
induction
proinflammatory
cytokines
CD4+
T
cells.
The
selenium-enhanced
production
was
confirmed
be
attributable
activation
ERK
Akt
pathways.
further
validated
our
cellular
SARS-CoV-2-infected
K18-hACE2
mice,
supplementation
alleviated
SARS-CoV-2-induced
lung
damage
characterized
by
decreased
alveolar
inflammatory
infiltrates
through
restoration
virus-repressed
selenoproteins
alleviate
oxidative
stress.
Our
approach
can
readily
extended
other
understand
defends
regulation
metallome.
Scientific Reports,
Год журнала:
2022,
Номер
12(1)
Опубликована: Янв. 31, 2022
Abstract
As
the
SARS-CoV-2
pandemic
persists,
methods
that
can
quickly
and
reliably
confirm
infection
immune
status
is
extremely
urgently
critically
needed.
In
this
contribution
we
show
combining
laser
induced
breakdown
spectroscopy
(LIBS)
with
machine
learning
distinguish
plasma
of
donors
who
previously
tested
positive
for
by
RT-PCR
from
those
did
not,
up
to
95%
accuracy.
The
samples
were
also
analyzed
LIBS-ICP-MS
in
tandem
mode,
implicating
a
depletion
Zn
Ba
subjects
inversely
correlate
CN
lines
LIBS
spectra.
Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(11)
Опубликована: Июль 19, 2024
A
quinoxaline‐based
ligand,
6,7‐dimethyl‐2,3‐di(2‐pyridyl)quinoxaline
(Me
2
dpq),
and
its
unique
binuclear
Co(II)‐Me
dpq
complex
were
prepared
analyzed
using
single
crystal
X‐ray
diffraction
several
spectroscopy
techniques.
Hirshfeld
surface
analyses
also
used
to
clarify
the
Me
ligand
packing.
The
crystallized
in
triclinic
P‐1
space
group
exhibited
a
distorted
trigonal
bipyramidal
geometry
around
cobalt(II)
ion.
Each
Co(II)
ion
coordinated
through
two
N
donor
centers
from
pyridyl
quinoxaline
rings
along
with
terminal
Cl
bridged
atoms.
binding
properties
of
CT‐DNA
studied
by
techniques,
namely
UV–Vis
spectroscopy,
fluorescence
quenching,
viscosity
measurements,
thermal
denaturation,
gel
electrophoresis.
interaction
tests
demonstrated
that
both
parent
bind
DNA
an
intercalative
way.
antioxidant
studies
novel
illustrated
significant
activity
against
DPPH
•
radicals.
vitro
cytotoxic
effect
Co(II)‐complex
on
MCF‐7
Hep‐G2
tumor
cell
lines
was
evaluated
MTT
assay.
showed
had
superior
toward
tested
lines.
Molecular
docking
synthesized
compounds
employed
figure
out
way
they
would
associate
biologically
macromolecular
target
B‐DNA
(PDB:
1BNA).
Thus,
this
study
is
anticipated
provide
opportunities
for
successful
utilization
many
medical
domains.
Agriculture,
Год журнала:
2025,
Номер
15(11), С. 1149 - 1149
Опубликована: Май 27, 2025
Selenium
(Se)
is
essential
for
human
health,
but
it
interacts
with
cadmium
(Cd).
However,
there
has
been
little
focus
on
developing
soil
health
evaluation
models
based
the
interaction
between
Se
and
heavy
metals,
or
transport
of
Cd
in
oilseed
rape.
Through
detection,
was
found
that
Yuanzhou
District
mostly
Se-rich
(average
0.62
mg
kg−1).
Correlation
analysis
showed
a
positive
correlation
content
(r
=
0.62,
p
<
0.01)
organic
matter
0.60,
0.01).
A
score
model
developed
performed
well,
indicating
can
be
used
to
estimate
relevant
scores.
Furthermore,
natural
rice
ranges
from
0.07
0.28
kg−1,
overall
enrichment
ability
rape
stronger
than
rice.
According
analysis,
significantly
correlated
stems
0.49,
0.37,
0.05).
As
result,
this
study
suggests
using
rice/oilseed
intercropping
farming
transfer
into
reduce
PLoS ONE,
Год журнала:
2023,
Номер
18(5), С. e0285606 - e0285606
Опубликована: Май 22, 2023
Background
Iron
plays
a
key
role
in
human
immune
responses;
however,
the
influence
of
iron
deficiency
on
coronavirus
disease
2019
(COVID-19)
vaccine
effectiveness
is
unclear.
Aim
To
assess
BNT162b2
messenger
RNA
COVID-19
preventing
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
infection
and
COVID-19–related
hospitalization
death
individuals
with
or
without
deficiency.
Methods
This
large
retrospective,
longitudinal
cohort
study
analyzed
real-world
data
from
Maccabi
Healthcare
Services
database
(covering
25%
Israeli
residents).
Eligible
adults
(aged
≥
16
years)
received
first
dose
between
December
19,
2020,
February
28,
2021,
followed
by
second
as
per
approved
label.
Individuals
were
excluded
if
they
had
SARS-CoV-2
before
vaccination,
hemoglobinopathy,
cancer
diagnosis
since
January
been
treated
immunosuppressants,
pregnant
at
time
vaccination.
Vaccine
was
assessed
terms
incidence
rates
confirmed
real-time
polymerase
chain
reaction
assay,
relative
risks
hospitalization,
mortality
(ferritin
<30
ng/mL
transferrin
saturation
<20%).
The
two-dose
protection
period
Days
7
to
28
after
Results
Data
184,171
(mean
[standard
deviation;
SD]
age
46.2
[19.6]
years;
81.2%
female)
versus
1,072,019
[SD]
46.9
[18.0]
46.2%
known
analyzed.
91.9%
(95%
confidence
interval
[CI]
83.7–96.0%)
92.1%
CI
84.2–96.1%)
for
those
(
P
=
0.96).
Of
patients
deficiency,
hospitalizations
occurred
19
100,000
during
reference
(Days
1–7
dose),
period,
respectively.
Mortality
comparable
groups:
2.2
(4/181,012)
population
1.8
(19/1,055,298)
Conclusions
suggest
that
>90%
effective
3
weeks
irrespective
iron-deficiency
status.
These
findings
support
use
populations
