Promising Schiff bases in antiviral drug design and discovery

Medicinal Chemistry Research, Год журнала: 2023, Номер 32(6), С. 1063 - 1076

Опубликована: Май 10, 2023

Язык: Английский

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Twice-Daily Oral Zinc in the Treatment of Patients With Coronavirus Disease 2019: A Randomized Double-Blind Controlled Trial

Clinical Infectious Diseases, Год журнала: 2022, Номер 76(2), С. 185 - 191

Опубликована: Ноя. 3, 2022

Zinc supplementation has been considered a potential therapy for coronavirus disease 2019 (COVID-19). We aimed to examine zinc efficacy in adult patients with COVID-19 infection.We conducted prospective, randomized, double-blind, placebo-controlled multicenter trial. Patients who were tested positive without end-organ failure randomized oral (n = 231) or matching placebo 239) 15 days. The primary combined outcome was death due intensive care unit (ICU) admission ≤30 days after randomization. Secondary outcomes included length of hospital stay inpatients and duration symptoms COVID-19-related hospitalization outpatients.190 (40.4%) ambulatory 280 (59.6%) hospitalized. Mortality at 30 6.5% the group 9.2% (OR: .68; 95% CI .34-1.35); ICU rates were, respectively, 5.2% 11.3% .43; .21-.87). Combined lower versus .58; .33-.99). Consistent results observed prespecified subgroups aged <65 years, those comorbidity, needed oxygen baseline. Length shorter (difference: 3.5 days; 2.76-4.23) inpatient group; decreased treatment outpatients 1.9 .62-2.6). No severe adverse events during study.Our showed that, patients, can decrease 30-day death, rate shorten symptom duration. Clinical Trials Registration. ClinicalTrials.gov, NCT05212480.

Язык: Английский

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Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta-analysis

Clinical Nutrition ESPEN, Год журнала: 2022, Номер 51, С. 120 - 127

Опубликована: Сен. 9, 2022

Язык: Английский

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The Significance of Zinc in Patients with Chronic Liver Disease

Nutrients, Год журнала: 2022, Номер 14(22), С. 4855 - 4855

Опубликована: Ноя. 17, 2022

Zinc is an essential trace element for the maintenance of life because it acts as a center activity or cofactor hundreds enzymes. deficiency causes variety symptoms, including anemia, dermatitis, stomatitis, alopecia, bedsores, decreased appetite, impaired growth, gonadal dysfunction, susceptibility to infection, and taste disorders, etc. In March 2017, zinc acetate hydrate, which had been approved Wilson disease in Japan, received additional indication hypozincemia. Hypozincemia frequently observed patients with chronic liver (CLD), especially cirrhosis, has recently shown that hypozincemia closely related development fibrosis increased risk carcinogenesis, addition appearance various subjective symptoms. Moreover, CLD may be associated sarcopenia (i.e., decrease muscle strength mass) frailty vulnerability), receive much attention these days. It assumed treatment hydrate will become widespread CLD. also have potential improving This review primarily outlines significance

Язык: Английский

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Effect of the vitamin D supplementation on clinical outcomes and inflammatory status in COVID-19 patients: an umbrella review

BMC Nutrition, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 29, 2025

The role of vitamin D supplementation in modulating clinical outcomes and inflammatory responses COVID- 19 patients has garnered significant interest. This umbrella review consolidates current evidence to evaluate the association between 19-related outcomes. A comprehensive search was conducted across multiple databases identify relevant systematic reviews meta-analyses. Studies assessing impact on disease severity, mortality, hospitalization, markers were included. Methodological quality assessed using standardized tools. findings suggest that may be associated with reduced mortality improved patients. Several studies reported a decrease markers, such as C-reactive protein interleukin- 6, following supplementation. However, variations study design, dosage regimens, baseline status limit generalizability results. Vitamin appears have potential improving Nevertheless, due heterogeneity among studies, further high-quality randomized controlled trials are warranted confirm these findings.

Язык: Английский

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Role of micronutrients in the modulation of immune system and platelet activating factor in patients with COVID-19; a narrative review

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Сен. 15, 2023

Background Dietary micronutrients may play important roles in the improvement of immune responses against SARS-CoV-2. This study aimed to assess effect on platelet activating factor (PAF) and immunity with a special focus coronavirus disease 2019 (COVID-19). Methods All paper published English effects including fat soluble vitamins, water minerals PAF, immunity, COVID-19 were collected from online valid databases. Results Vitamin A modulate expression PAF-receptor gene patients COVID-19. D inflammatory response through influencing PAF pathway. E improve related heart injuries by exert anti-PAF activities. C status have anti-inflammatory micro-thrombotic SARS-CoV-2 patients. Furthermore, some trace elements such as copper, selenium, iron key strengthens inactivate acetyl hydrolase. Conclusion narrative review highlighted importance function modulation Further longitudinal studies are warranted.

Язык: Английский

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The Role of Nutraceuticals in the Prevention and/or Treatment of COVID-19: An Umbrella Review

CAND Journal, Год журнала: 2023, Номер 30(4), С. 66 - 80

Опубликована: Дек. 28, 2023

Background: To identify the results of published review literature regarding nutraceuticals, including probiotics, melatonin, poly-unsaturated fatty acids (PUFAs), quercetin, N-acetyl cysteine (NAC), and propolis as they relate to prevention and/ or treatment COVID-19 (CV) and/or long COVID (long CV) outline key areas consider for clinical application further research. Methods: This paper is part a six-part umbrella which progresses from living review. incorporates systematic reviews narrative nutraceuticals. A live search occurred monthly in PubMed Google Scholar May 2022 2023. Assessing Methodological Quality Systematic Reviews Version 2 (AMSTAR-2) scoring assessed quality, while Scale Assessment Narrative Review Articles (SANRA) guidelines evaluated reviews. Only those studies that were relevant nutraceuticals outlined above addressed CV extracted each Results: Fifteen 16 included this Studies indicate may be beneficial improving rate recovery various symptoms, conversion parameters such duration hospital stay risk intensive care unit (ICU) admission, an improvement laboratory tests. Conclusion/Summary: The broad antioxidant, anti-inflammatory, antiviral, immune modulatory characteristics make reasonable choices Of discussed above, NAC, quercetin greatest potential benefit CV.

Язык: Английский

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Minerals and Antioxidant Micronutrients Levels and Clinical Outcome in Older Patients Hospitalized for COVID-19 during the First Wave of the Pandemic

Nutrients, Год журнала: 2023, Номер 15(6), С. 1516 - 1516

Опубликована: Март 21, 2023

Excessive inflammatory response has been implicated in severe respiratory forms of coronavirus disease 2019 (COVID-19). Trace elements such as zinc, selenium, and copper are known to modulate inflammation immunity. This study aimed assess the relationships between antioxidant vitamins mineral trace levels well COVID-19 severity older adults hospitalized. In this observational retrospective cohort study, copper, vitamin A, β-carotene, E were measured 94 patients within first 15 days hospitalization. The outcomes in-hospital mortality secondary or COVID-19. A logistic regression analysis was conducted test whether minerals independently associated with severity. (average age 78 years), (46%) lower zinc (p = 0.012) β-carotene < 0.001) concentrations, (15%) 0.009), selenium 0.014), 0.001), 0.002) concentrations. analysis, remained (aOR 2.13, p 0.018) death 0.165, 0.021) Low plasma concentrations poor prognosis people hospitalized

Язык: Английский

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Interim Report on a Live Review of Systematic Reviews of Natural Health Products and Natural Therapies in the Prevention and/or Treatment of COVID-19

CAND Journal, Год журнала: 2023, Номер 30(1), С. 3 - 15

Опубликована: Март 30, 2023

Objective: This living review of systematic reviews investigates the types and volume research pertaining to natural health products therapies as they relate prevention and/or treatment COVID-19 post-COVID syndrome. Methods: A monthly search for published peer-reviewed topic was initiated May 2022 is ongoing. Using a keyword strategy with clear inclusion exclusion criteria, summary studies included, overall outcome focus were assessed. Results: total 225 encompassing 5,636 randomized controlled trials (49.8%, n=112), observational (21.3%, n=48), clinical (20.4%, n=46), other (12%, n=27) included. Of those, 28.9% (n=65) focused on prevention, 67.6% (n=152) treatment, 3.1% (n=8) post-COVID. The reviewed included herbal medicine, vitamins, minerals, products, therapies, 83.5% (n=188) all stating positive beneficial potential or therapy investigated. Conclusion: concludes that there growing interest in respect infections addressing disease severity mortality, especially adjunct conventional medical intervention. Nonetheless, lack high-quality evidence consistency reporting across large breadth management options.

Язык: Английский

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Association between Average Vitamin D Levels and COVID-19 Mortality in 19 European Countries—A Population-Based Study

Nutrients, Год журнала: 2023, Номер 15(22), С. 4818 - 4818

Опубликована: Ноя. 17, 2023

Early epidemic reports have linked low average 25(OH) vitamin D levels with increased COVID-19 mortality. However, there has been limited updated research on and its impact This study aimed to update the initial report studying link between deficiency mortality by using multi-country data in 19 European countries up middle of June 2023. for included this were downloaded from Our World Data 1 March 2020, 14 2023, statistical analysis. The collected conducting a literature review. A generalized estimation equation model was used data. Compared ≤50 nmol/L, greater than 50 nmol/L had lower rates (RR = 0.794, 95% CI: 0.662–0.953). statistically significant negative Spearman rank correlation observed We also found significantly high levels. Randomized trials supplementation are needed. In meantime, issue use should be debated relation ongoing discussions national post-COVID-19 resilience against future pandemics.

Язык: Английский

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