The use of interleukin-10 (IL-10) and phosphorus levels as predictors of the time to improvement in COVID-19 patients: a prospective study

Egyptian Journal of Bronchology, Год журнала: 2024, Номер 18(1)

Опубликована: Окт. 7, 2024

Abstract Early detection of COVID-19 improves the chance recovery and helps identify high-risk patients. Our study aimed to statistically predict time improvement with admission data Methods : prospective cohort occurred between January September 2022 at Alexandria University Hospital’s outpatient clinic isolation department. We enrolled 43 patients after assessing their eligibility collecting baseline data. Results The mean age was 34.8 years (± 12.3). Most them were females (65.1%). oxygen saturation 95.2% 2.8). used linear regression how long it would take improve [time (days) = 1.186*P (mmol/L) + 0.010*IL-10 (pg/mL)]. Its diagnostic performance 0.723 (95% CI: 0.552–0.894), accurate predicting within a week but not longer delays; additionally, its positive negative predictive values 56.3% 85.2%, respectively. Conclusion recommend monitoring phosphorus interleukin-10 levels. time-to-improvement delay negatively correlated reduction in upon admission. Additionally, for every 0.84 meq/L increase or 100 pg/mL interleukin-10, there 1-day provided that other constant, coefficient determination 85.9%.

Язык: Английский

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Total network controllability analysis discovers explainable drugs for Covid-19 treatment

Biology Direct, Год журнала: 2023, Номер 18(1)

Опубликована: Сен. 5, 2023

Abstract Background The active pursuit of network medicine for drug repurposing, particularly combating Covid-19, has stimulated interest in the concept structural controllability cellular networks. We sought to extend this theory, focusing on defense rather than control cell against viral infections. Accordingly, we extended total and introduced hubs. Perturbing any hub may render uncontrollable by exogenous stimuli like infections, so hubs are ideal targets. Results developed an efficient algorithm identify all hubs, applying it a largest homogeneous human protein interactions, including interactions between SARS-CoV-2 proteins. Our method recognized 65 druggable with enriched antiviral functions. Utilizing these categorized potential drugs into four groups: anti-inflammatory agents, acting central nervous system, dietary supplements, compounds enhancing immunity. An exemplification our approach’s effectiveness, Fostamatinib, initially chronic immune thrombocytopenia, is now clinical trials treating Covid-19. Preclinical trial data demonstrated that Fostamatinib could reduce mortality rates, ICU stay length, disease severity Covid-19 patients. Conclusions findings confirm efficacy novel strategy leverages as This approach provides insights molecular mechanisms therapeutics making valuable tool interpretable discovery. new general applicable repurposing other diseases.

Язык: Английский

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Vitamin D: review of physiology and clinical uses

Minerva Endocrinology, Год журнала: 2023, Номер 48(1)

Опубликована: Март 1, 2023

Interest in vitamin D has increased within the scientific community due to impact of osteoporosis aging population. Vitamin receptors are present many tissues and low status been associated with diseases observational studies. There was hope that enhanced provision might help prevent treat some widespread disorders. Some these hopes have refuted by results recent large well-conducted randomized trials. This review provides an overview basic physiology update on evidence base for its clinical applications.

Язык: Английский

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Use of Incinerated Eggshells to Produce Pidan

Sustainability, Год журнала: 2022, Номер 14(11), С. 6797 - 6797

Опубликована: Июнь 1, 2022

Preserved eggs (pidans) are used in traditional Chinese cuisines. However, the alkaline conditions and metal ions generated during its preparation have caused some concerns. This study developed an innovative process for pidan processing using incinerated eggshell powder, abundant by-product that can generate a highly solution provide calcium (Ca2+). Either 0.5, 3, or 5% of powder was basic pickling. Different combinations ZnSO4 (0.175%), MgCl2 (0.08%), CuSO4 (0.16%) were added. Duck pickled 25 days at 25–27 °C, followed by 14 ripening. The processed containing 0.175% demonstrated closest physiochemical sensory characteristics to commercial pidans. Thus, results offer new technique manufacture pidans reduce harmful impact on human health environment.

Язык: Английский

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A Potential Role for Zinc to Enhance Treatment for Coronavirus Disease 2019 (COVID-19)?

Clinical Infectious Diseases, Год журнала: 2022, Номер 76(2), С. 192 - 193

Опубликована: Окт. 25, 2022

Язык: Английский

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A systematic review: The relationship of COVID-19 to iron, zinc, and vitamin D

Journal of Family Medicine and Primary Care, Год журнала: 2023, Номер 12(10), С. 2392 - 2400

Опубликована: Окт. 1, 2023

Primary care physicians are crucial in identifying SARS-CoV-2 infection and transferring suspected cases since they on the front lines of health care. Micronutrients used as an adjunctive treatment for viral respiratory infections. Because there is currently no effective antiviral therapy COVID-19, micronutrients such iron, zinc, vitamin D may be important survival critically ill patients.To establish emphasize a relationship between to COVID-19.PubMed database was articles selection. All relevant our review with topics regarding use zinc COVID-19 patients. We excluded other articles, which not related this field did match inclusion criteria. The data extracted according specific form double reviewed by group members.The search mentioned returned total 3614 studies that were included title screening. 2910 them abstract screening, lead exclusion 1064 articles. remaining 1846 publications full texts reviewed. full-text revision led 1812 studies, 34 enrolled final extraction.This study raised idea employing ingredients either protect patients or speed up recovery, decrease symptoms severity mortality rates.

Язык: Английский

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Total network controllability analysis discovers explainable drugs for Covid-19 treatment

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Июль 14, 2023

Background The active pursuit of network medicine for drug repurposing, particularly combating Covid-19, has stimulated interest in the concept structural control capability cellular networks. We sought to extend this theory, focusing on defense rather than cell against viral infections. Accordingly, we extended controllability total and introduced hubs. Perturbing any hub may render uncontrollable by exogenous stimuli like infections, so hubs are ideal targets. Results developed an efficient algorithm identify all hubs, applying it largest homogeneous human protein interactions, including interactions between SARS-CoV-2 proteins. Our method recognized 65 druggable with enriched antiviral functions. Utilizing these categorized potential drugs into four groups: anti-inflammatory agents, acting central nervous system, dietary supplements, compounds enhancing immunity. An exemplification our approach's effectiveness, Fostamatinib, a initially chronic immune thrombocytopenia, is now clinical trials treating Covid-19. Preclinical trial data demonstrated that Fostamatinib could reduce mortality rates, ICU stay length, disease severity Covid-19 patients. Conclusions findings confirm efficacy novel strategy leverages as This approach provides insights molecular mechanisms therapeutics making valuable tool interpretable discovery.

Язык: Английский

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Vitamins for the Prevention and/or Treatment of COVID-19: An Umbrella Review

CAND Journal, Год журнала: 2023, Номер 30(4), С. 15 - 31

Опубликована: Дек. 28, 2023

Objective: This umbrella review synthesizes the existing literature on role of vitamins for COVID-19 prevention and management. The objective is to elucidate potential preventive therapeutic dimensions these vitamins, highlight clinical applicability, identify avenues future research. Methods: A systematic search was conducted using PubMed Google Scholar, with predefined key words each vitamin combined COVID-19-related terms. Narrative reviews were included, following Cochrane guidelines. AMSTAR scoring used assess quality, while SANRA guidelines evaluate narrative reviews. Data extraction, synthesis, reference overlap conducted. Findings: (n=14) revealed preclinical benefits A, B group, C, D, E (no research K found) in management, immune modulation anti-inflammatory responses. Of (n=44), none included or E. Some exhibited potential, significant associations between C supplementation reduced severity. Many findings also found D deficiency heightened risks, as well promising effects supplementation. Conclusion: Vitamins hold mechanistic rationale combating COVID-19, suggested by In reviews, underscores its severity, show adjunct therapies. highlights comprehensive efficacy addressing challenges that warrant further investigation.

Язык: Английский

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The Role of Minerals in COVID-19: An Umbrella Review

CAND Journal, Год журнала: 2023, Номер 30(4), С. 5 - 14

Опубликована: Дек. 28, 2023

Background: This umbrella review aims to synthesize the existing literature on preventive and therapeutic benefits of minerals zinc, selenium, iron, copper, magnesium, phosphorus, calcium in context COVID-19 prevention management. The objective is highlight clinical applicability identify avenues future research. Methods: A systematic search was conducted PubMed Google Scholar databases using predefined keywords for each mineral combined with COVID-19–related terms. Narrative reviews were included, following Cochrane guidelines. AMSTAR scoring used assess quality, while SANRA guidelines evaluate narrative reviews. Data extraction synthesis performed, reference overlap analysis (see Table S1 supplemental material). Results: highlighted range properties including antimicrobial, antiviral, antioxidant, anti-inflammatory, immune-modulating essential role they play treatment many conditions, acute respiratory conditions such as COVID-19. that deficiency key are associated increased risk infection decreased rate recovery. Iron supplementation may be beneficial functional anemia common those Zinc shorten duration olfactory dysfunction. Conclusion/Summary: Deficiency increase decrease recovery it relates Supplementation correction iron selenium deficiencies improve outcomes immune responses COVID-19."

Язык: Английский

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Exploring micronutrient supplements in disease conditions: are they effective?

Journal of Food Nutrition and Diet Science, Год журнала: 2024, Номер unknown, С. 1 - 17

Опубликована: Янв. 26, 2024

Nutrition is essential for the health and well-being of all living beings sourced from foods different origins types. Most importantly, food must contain carbohydrates, proteins, fat, vitamins minerals in a balanced form to achieve optimum benefits. Vitamins minerals, also known as micronutrients, are characterised by their nature, quantity role normal metabolic activities. In humans, micronutrients exclusively obtained or supplements. addition, vitamin D3 synthesized de novo with aid sunlight, while B K gut resident bacteria. Micronutrients play an important disease states have become most widely used dietary supplements world. However, how effective they against diseases controversial conflicting reports continue emerge, especially where insufficient data available. This review highlights micronutrient alleviation communicable non-communicable diseases. Data were retrieved literature databases including African Journal Online, Google Scholar, PubMed Web Science, among others, hits on nutrients, mineral supplements: Only relevant information 1993-2023 (30 years) was considered. As these supplementations generally beneficial, it worthy note that treatment still limited data.

Язык: Английский

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