Associations of phthalates with NAFLD and liver fibrosis: A nationally representative cross-sectional study from NHANES 2017 to 2018 DOI Creative Commons
Xingying Chen,

Feng Tian,

Jianfeng Wu

и другие.

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Ноя. 22, 2022

Although phthalates are common environmental pollutants, few studies have focused on the relationship of exposure with non-alcoholic fatty liver disease (NAFLD) or fibrosis, and especially, alternative been questioned in recent years about whether they better choices. Thus, this study aimed to explore associations major NAFLD fibrosis.Data 1450 adults from National Health Nutrition Examination Survey (NHANES) 2017-2018 were collected. The urinary metabolite concentrations di-2-ethylhexyl phthalate (DEHP), diisononyl (DINP) diisodecyl (DIDP) detected. Controlled attenuation parameter (CAP) median stiffness measurement (LSM) acquired for quantitative diagnosis fibrosis by vibration-controlled transient elastography. Multivariate logistic regression analysis linear performed examine between fibrosis.After adjustment potential factors, prevalence was significantly elevated among those fourth quartile mono-(2-ethyl-5-carboxypentyl) (OR, 95%CI = 2.719, 1.296, 5.700, P 0.016), mono (2-ethyl-5-hydroxyhexyl) 2.073, 1.111, 3.867, 0.037). No significant association found NAFLD. similar result gained that MECPP still associated Ln CAP (Q4 vs. Q1: β, 0.067, 0.017, 0.118, 0.027). After same covariates, no logistics analysis.All all, higher is correlated DEHP but not DINP DIDP American adults. There defined as LSM ≥ 8 Kpa. Nevertheless, further research needed provide evidence causality.

Язык: Английский

Lycopene ameliorates DEHP exposure-induced renal pyroptosis through the Nrf2/Keap-1/NLRP3/Caspase-1 axis DOI
Muzi Li, Yi Zhao, Xueyan Dai

и другие.

The Journal of Nutritional Biochemistry, Год журнала: 2023, Номер 113, С. 109266 - 109266

Опубликована: Янв. 4, 2023

Язык: Английский

Процитировано

20
Lycopene ameliorates atrazine-induced spatial learning and memory impairments by inhibiting ferroptosis in the hippocampus of mice DOI

Shi‐Yong Zhu,

Jun-Ze Jiang,

Jia Lin

и другие.

Food and Chemical Toxicology, Год журнала: 2023, Номер 174, С. 113655 - 113655

Опубликована: Фев. 13, 2023

Язык: Английский

Процитировано

20
Cadmium aggravates the blood-brain barrier disruption via inhibition of the Wnt7A/β-catenin signaling axis DOI
Chenxi Li,

Milton Talukder,

Yaru Xu

и другие.

Environmental Pollution, Год журнала: 2023, Номер 324, С. 121400 - 121400

Опубликована: Март 4, 2023

Язык: Английский

Процитировано

20
Activation of Nrf2 and FXR via Natural Compounds in Liver Inflammatory Disease DOI Open Access
Marta Belka, Aleksandra Gostyńska, Maciej Stawny

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11213 - 11213

Опубликована: Окт. 18, 2024

Liver inflammation is frequently linked to oxidative stress and dysregulation of bile acid fatty metabolism. This review focuses on the farnesoid X receptor (FXR), a critical regulator homeostasis, its interaction with nuclear factor erythroid 2-related 2 (Nrf2), key modulator cellular defense against stress. The explores interplay between FXR Nrf2 in liver inflammatory diseases, highlighting potential therapeutic effects natural agonists. Specifically, compounds such as auraptene, cafestol, curcumin, fargesone A, hesperidin, lycopene, oleanolic acid, resveratrol, rutin, ursolic withaferin A are reviewed for their ability modulate both pathways. article discusses alleviate inflammation, stress, damage diseases metabolic-associated disease (MAFLD), cholestatic injury, viral hepatitis. In addition, we address molecular mechanisms driving including immune responses, accumulation, while also summarizing relevant experimental models. emphasizes promising targeting pathways using compounds, paving way future treatments diseases. Finally, limitations clinical application were indicated, further research directions proposed.

Язык: Английский

Процитировано

6
Atrazine-induced oxidative damage via modulating xenobiotic-sensing nuclear receptors and cytochrome P450 systems in cerebrum and antagonism of lycopene DOI
Xueyan Dai,

Jia Lin,

Shi‐Yong Zhu

и другие.

Food and Chemical Toxicology, Год журнала: 2022, Номер 170, С. 113462 - 113462

Опубликована: Окт. 8, 2022

Язык: Английский

Процитировано

24
Lycopene Attenuates Di(2-ethylhexyl) Phthalate-Induced Mitochondrial Damage and Inflammation in Kidney via cGAS–STING Signaling DOI
Muzi Li, Xueyan Dai, Yingxin Zhao

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2022, Номер 71(1), С. 569 - 579

Опубликована: Дек. 30, 2022

Di(2-ethylhexyl) phthalate (DEHP) is a highly harmful and persistent environmental pollutant. Due to its unique chemical composition, it frequently dissolves enters the environment endanger human animal health. Lycopene natural bioactive component that can potentially reduce risk of factor-induced chronic diseases. The present study sought explore role underlying mechanism lycopene (LYC) on DEHP-induced renal inflammatory response apoptosis. In this study, mice were orally treated with LYC (5 mg/kg BW/day) and/or DEHP (500 or 1000 for 28 days. Our results indicated prevented histopathological alterations ultrastructural injuries, including decreased mitochondrial membrane potential (ΔΨm), PINK1/Parkin pathway-mediated mitophagy, energetic deficit. When damaged mitochondria release DNA (mtDNA) into cytosol, alleviate inflammation apoptosis caused by exposure activating cyclic GMP-AMP synthase-stimulator interferon gene (cGAS-STING) signal pathway. Collectively, our data demonstrate mitophagy pathway then through cGAS-STING

Язык: Английский

Процитировано

24
Drinking alkaline mineral water confers diarrhea resistance in maternally separated piglets by maintaining intestinal epithelial regeneration via the brain-microbe-gut axis DOI Creative Commons
Jian Chen,

Bi-Chen Zhao,

Xueyan Dai

и другие.

Journal of Advanced Research, Год журнала: 2022, Номер 52, С. 29 - 43

Опубликована: Дек. 17, 2022

Diarrhea has the fourth-highest mortality rate of all diseases and causes a large number infant deaths each year. The maternally separated (MS) piglet (newly weaned piglet) is an excellent model to investigate treatment diarrhea in infants. Drinking alkaline mineral water potential be therapeutic gastrointestinal disorders, particularly diarrhea, but supporting evidence from system studies mechanisms involved have yet reported.This study aims determine whether drinking confers resistance MS piglets under weaning stress what fundamental are.MS were used create stress-induced intestinal disorder-diarrhea susceptibility model. A total 240 randomly divided into two groups (6 pens/group 20 piglets/pen). IPEC-J2 cell line was for vitro evaluation. An complex (AMC) employed, its effect on hypothalamus-pituitary-adrenocortical (HPA) axis, gut microbes, morphology, epithelial (IEC) proliferation differentiation investigated using variety experimental methodology.AMC reduced by inhibiting HPA ameliorating microbiota structure, stimulating IEC differentiation. Apparently, brain-microbe-gut axis linked with AMC conferring piglets. Mechanistically, decreased hormones (COR Hpt) secretion suppressing which then increased abundance beneficial microbes; accordingly, maintained promoted stem cells (ISC) goblet Paneth activating Wnt/β-catenin signaling pathway. In absence (in vitro), activated LPS-induced inhibition significantly Lgr5 + cells, whereas had no differentiation.Drinking maintaining regeneration via axis; thus, this provides prevention strategy young mammals at risk diarrhea.

Язык: Английский

Процитировано

23
Nano-Selenium Antagonized Cadmium-Induced Liver Fibrosis in Chicken DOI
Xiaohan Sun,

Mei‐Wei Lv,

Yingxin Zhao

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2022, Номер 71(1), С. 846 - 856

Опубликована: Дек. 21, 2022

Cadmium is a global ecological toxic pollutant; in animals, hepatotoxic fibrosis caused by bioaccumulation of Cd through food chains. We determined the path nano-Se antagonism Cd-induced hepatocyte pyroptosis targeting APJ-AMPK-PGC1α pathway, using an vivo model hepatotoxicity. All 1-day-old chicks were treated with (140 mg/kg BW/day) and/or (0.3 or 0.6 for 90 days. The result showed that (1.55 ± 0.148) activated NLRP3 inflammasome 49.903% as compared to Con group (1.034 0.008) release (2.824 0.057). Compared (1.010 0.021), Kupffer cells 219.109% more activate astrocytes resulting 185.149% hepatic fibrosis. However, degree H-Se + (1.252 0.056) was 56.5278% (p < 0.001) lower than (2.880 0.124). Therefore, this study established pyroptotic hepatocytes and could be targeted antagonizing toxicity, which reveals potential new approach treatment liver triggered pollution.

Язык: Английский

Процитировано

23
Hepatotoxic response of perfluorooctane sulfonamide (PFOSA) in early life stage zebrafish (Danio rerio) is greater than perfluorooctane sulfonate (PFOS) DOI
Rongrong Xuan,

Xiaojian Qiu,

Jiazhen Wang

и другие.

Journal of Hazardous Materials, Год журнала: 2023, Номер 461, С. 132552 - 132552

Опубликована: Сен. 14, 2023

Язык: Английский

Процитировано

16
Low-dose phthalates promote breast cancer stem cell properties via the oncogene ΔNp63α and the Sonic hedgehog pathway DOI Creative Commons
Wanshuang Cao,

Meng-jiu Zhao,

Yue Chen

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 252, С. 114605 - 114605

Опубликована: Фев. 6, 2023

The omnipresence of human phthalate (PAE) exposure is linked to various adverse health issues, including breast cancer. However, the effects low-dose PAE on cancer stem cells (BCSCs) and underlying mechanism remain unexplored.BCSCs from cell lines (MDA-MB-231 MCF-7) were enriched using a tumorsphere formation assay. Gene protein expression was detected by measurement quantitative real-time reverse transcription PCR, western blot, immunofluorescence assays. Transient transfection assays used evaluate involvement Gli1, signaling pathway molecule ΔNp63α, an oncogene in influencing PAE-induced characteristics BCSCs.PAE (butylbenzyl phthalate, BBP; di-butyl DBP; di-2-ethylhexyl DEHP) 10-9 M significantly promoted ability BCSCs. Breast spheroids with had higher levels BCSC marker mRNA expression, activated sonic hedgehog (SHH) pathway, increased oncogene, ΔNp63α. Furthermore, suppression SHH attenuated PAEs And overexpression ΔNp63α enhanced BCSCs, while low inhibited promotion BCSCs pathway.Low-dose properties ΔNp63α- SHH-dependent manner. influence its relevance for lowest observed effect concentrations requires further investigation, precise needs be explored.

Язык: Английский

Процитировано

15