Bisphenol A and Its Emergent Substitutes: State of the Art of the Impact of These Plasticizers on Oxidative Stress and Its Role in Vascular Dysfunction DOI Creative Commons

José R. Palacios-Valladares,

Yesenia I. Martinez-Jimenez,

Vanessa Morillon-Torres

и другие.

Antioxidants, Год журнала: 2024, Номер 13(12), С. 1468 - 1468

Опубликована: Ноя. 29, 2024

The “One Health approach” has evidenced the significant impact of xenobiotic exposure to health, and humans are a relevant target for their toxic effects. Bisphenol A (BPA) exerts ubiquitous source in all ecosystems. Given its endocrine-disrupting harmful consequences on several countries have enforced new regulations reduce BPA. Cardiovascular diseases (CVDs) complex conditions that lead higher mortality worldwide, where family history, lifestyle, environmental factors, like BPA exposure, remarkable contribution. This chemical compound is most widely used plastic epoxy resin manufacturing been associated with effects human health. Therefore, new-generation bisphenols (NGBs) replacing use, arguing they do not harm Nonetheless, knowledge about whether NGBs secure options scanty. Although BPA’s organs systems documented, role CVDs yet be explored. review’s goals focused processes endothelial activation (EA)–endothelial dysfunction (ED), cornerstone development, bisphenols’ (BPs) these through oxidant antioxidant system alteration. Despite scarce evidence pro-oxidant NGBs, our review demonstrated comparable effect results from present suggest biological mechanisms explain BPs cardiotoxic stress ↔ inflammatory response EA ED → atherosclerotic plate coagulation promotion. Other contributing CVD development include altered lipid metabolism, ionic channels, different intracellular pathways, which contribute perpetuation concerted manner.

Язык: Английский

Liver and Pancreatic Toxicity of Endocrine-Disruptive Chemicals: Focus on Mitochondrial Dysfunction and Oxidative Stress DOI Open Access
Adina V. Lința,

Bogdan M. Lolescu,

C. Ilie

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7420 - 7420

Опубликована: Июль 6, 2024

In recent years, the worldwide epidemic of metabolic diseases, namely obesity, syndrome, diabetes and metabolic-associated fatty liver disease (MAFLD) has been strongly associated with constant exposure to endocrine-disruptive chemicals (EDCs), in particular, ones able disrupt various pathways. EDCs have a negative impact on several human tissues/systems, including metabolically active organs, such as pancreas. Among their deleterious effects, induce mitochondrial dysfunction oxidative stress, which are also major pathophysiological mechanisms underlying diseases. this narrative review, we delve into current literature EDC toxicity effects pancreatic tissues terms impaired function redox homeostasis.

Язык: Английский

Процитировано

8
A comprehensive review of medicinal plants and their beneficial roles in alleviating bisphenol A–induced organ toxicity DOI Creative Commons

Shabnam Dolatabadi,

Sara Rahimzadeh Oskuei,

Soghra Mehri

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Язык: Английский

Процитировано

0
Cinnamic Acid Abrogates Bisphenol A-induced Hepatotoxicity via Suppression of Pro-inflammatory Cytokine and Modulation of Gene Expressions of Antioxidant Enzymes in Rats DOI Creative Commons
Anne A. Adeyanju,

Emmanuel Ayomitide Akinwunmi,

Mojisola Esther Karigidi

и другие.

Toxicology Reports, Год журнала: 2025, Номер unknown, С. 101995 - 101995

Опубликована: Март 1, 2025

Bisphenol A (BPA) is regularly used to produce plastic products. Its hepatotoxicity has been unveiled. The effects of cinnamic acid on BPA exposure have not comprehensively studied, and the key mechanism action yet be unraveled. Rats were allocated into 5 groups. Group 1 (control) was given corn oil. 2 received for 14 consecutive days. 3 at 50 mg/kg in co-administration with while group 4 100 mg/kg, BPA. Cinnamic (CA) only (100 mg/kg) 5. significantly decreased catalase, glutathione-S-transferase, superoxide dismutase activities non-significantly diminished glutathione level. reduction gene expression catalase accompanied this. Our result showed significant elevation mRNA level tumor necrosis factor-α elevated malondialdehyde by alanine transaminase aspartate addition increased levels total cholesterol, triglycerides, very low-density lipoprotein reduced high-density reflected detrimental effect liver. results revealed that could alleviate pro-inflammatory cytokine oxidative stress downregulating gene. histopathological evaluation confirmed biochemical results. Hepatic alterations ameliorated when co-administered These findings suggest downregulation TNF-α induced may participate suppressing BPA-induced stress. This offers a new idea unmask underlying acid's interference hepatic damage.

Язык: Английский

Процитировано

0
Removal of bisphenol A at full-scale wastewater treatment plants and antagonistic effects of chlorogenic acid on it DOI
Runlan Yu, Peng Li

International Journal of Environmental Science and Technology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 5, 2025

Язык: Английский

Процитировано

0
Human circulatory proteome interaction, oxidative stress-associated signalling and cardiovascular implications during titanium dioxide nanoparticle (TiO2-NP) exposure DOI
Gobichettipalayam Balasubramaniam Maadurshni, Balamurali Mahalakshmi, M. Nagarajan

и другие.

Molecular Omics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The increasing exposure to nanoparticles raises a concern over their toxicity.

Язык: Английский

Процитировано

0
Endocrine disrupting chemical Bisphenol A and its association with cancer mortality: a prospective cohort study of NHANES DOI Creative Commons
Ying Yuan, Qian Chen, Xiaorong Ding

и другие.

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Фев. 23, 2024

Introduction There is evidence suggesting that Bisphenol A (BPA) associated with increased all-cause mortality in adults. However, the specific nature of relationship between BPA exposure and cancer remains relatively unexplored. Methods The National Health Nutrition Examination Survey (NHANES) dataset was used to recruit participants. Urinary assessed using liquid chromatography-mass spectrum (LC–MS). Through use multivariable Cox proportional hazard regressions constrained cubic splines, relationships urine death from all causes were investigated. Results This study has a total 8,035 participants, 137 died cancers after 7.5-year follow-up. median level 2.0 g/mL. levels not independently mortality. For mortality, second quartile’s multivariable-adjusted ratio 0.51 (95% confidence interval: 0.30 0.86; p = 0.011) compared lowest quartile. restricted splines showed association nonlinear (p for nonlinearity 0.028) inflection point 1.99 ng/mL. Conclusion U-shaped risk lower less than ng/mL higher

Язык: Английский

Процитировано

3
Construction of an Adverse Outcome Pathway for the Cardiac Toxicity of Bisphenol A by Using Bioinformatics Analysis DOI Creative Commons

L. Zhang,

Lin Tian,

Baofang Liang

и другие.

Toxicology, Год журнала: 2024, Номер 509, С. 153955 - 153955

Опубликована: Сен. 19, 2024

Bisphenol A (BPA), a common endocrine disruptor, has shown cardiovascular toxicity in several epidemiological studies, as well vivo and vitro experimental studies. However, the related adverse outcome pathway (AOP) of BPA remains unraveled. This study aimed to develop an AOP for cardiac through bioinformatics analysis. The interactions among BPA, genes, phenotypes, were retrieved from databases, including Comparative Toxicogenomics Database, Computational Toxicology, DisGeNet, MalaCards. target genes part phenotypes obtained by Venn analysis literature screening. Gene Ontology Kyoto Encyclopedia Genes Genomes enrichment performed using DAVID online tool obtain other phenotypes. hypotheses exposure heart disease established evaluated comprehensively quantitative weight evidence (QWOE) method. included ESR2, MAPK1, TGFB1, ESR1, contraction, muscle cellular Ca

Язык: Английский

Процитировано

1
Bisphenol A and Its Emergent Substitutes: State of the Art of the Impact of These Plasticizers on Oxidative Stress and Its Role in Vascular Dysfunction DOI Creative Commons

José R. Palacios-Valladares,

Yesenia I. Martinez-Jimenez,

Vanessa Morillon-Torres

и другие.

Antioxidants, Год журнала: 2024, Номер 13(12), С. 1468 - 1468

Опубликована: Ноя. 29, 2024

The “One Health approach” has evidenced the significant impact of xenobiotic exposure to health, and humans are a relevant target for their toxic effects. Bisphenol A (BPA) exerts ubiquitous source in all ecosystems. Given its endocrine-disrupting harmful consequences on several countries have enforced new regulations reduce BPA. Cardiovascular diseases (CVDs) complex conditions that lead higher mortality worldwide, where family history, lifestyle, environmental factors, like BPA exposure, remarkable contribution. This chemical compound is most widely used plastic epoxy resin manufacturing been associated with effects human health. Therefore, new-generation bisphenols (NGBs) replacing use, arguing they do not harm Nonetheless, knowledge about whether NGBs secure options scanty. Although BPA’s organs systems documented, role CVDs yet be explored. review’s goals focused processes endothelial activation (EA)–endothelial dysfunction (ED), cornerstone development, bisphenols’ (BPs) these through oxidant antioxidant system alteration. Despite scarce evidence pro-oxidant NGBs, our review demonstrated comparable effect results from present suggest biological mechanisms explain BPs cardiotoxic stress ↔ inflammatory response EA ED → atherosclerotic plate coagulation promotion. Other contributing CVD development include altered lipid metabolism, ionic channels, different intracellular pathways, which contribute perpetuation concerted manner.

Язык: Английский

Процитировано

1