Journal of Reproductive Immunology, Год журнала: 2020, Номер 140, С. 103146 - 103146
Опубликована: Май 19, 2020
Язык: Английский
American Journal of Obstetrics and Gynecology, Год журнала: 2020, Номер 224(3), С. 251 - 257
Опубликована: Окт. 19, 2020
Bacterial vaginosis, pelvic inflammatory disease, and endometritis are infections of the genital tract that can lead to many adverse health outcomes, including infertility. vaginosis is characterized by a lower prevalence lactobacilli higher anaerobic bacteria, Gardnerella vaginalis, Megasphaera spp., Atopobium vaginae. Endometritis disease caused ascension pathogenic bacteria uterus, although mechanisms which they do so unclear. chronic endometritis, have been linked infertility in retrospective prospective trials. Similarly, causes bacterial endometritis-related likely multifactorial stem from inflammation, immune targeting sperm antigens, presence toxins, increased risk sexually transmitted infections. Diagnosis treatment before attempting conception may be important components preconceptional care for symptomatic women improve outcomes natural assisted reproduction.
Язык: Английский
Процитировано
245
Microbiome, Год журнала: 2022, Номер 10(1)
Опубликована: Янв. 4, 2022
Abstract Background Previous evidence indicates associations between the female reproductive tract microbiome composition and outcome in infertile patients undergoing assisted reproduction. We aimed to determine whether endometrial microbiota is associated with outcomes of live birth, biochemical pregnancy, clinical miscarriage or no pregnancy. Methods Here, we present a multicentre prospective observational study using 16S rRNA gene sequencing analyse fluid biopsy samples before embryo transfer cohort 342 asymptomatic for infection treatments. Results A dysbiotic profile composed Atopobium , Bifidobacterium Chryseobacterium Gardnerella Haemophilus Klebsiella Neisseria Staphylococcus Streptococcus was unsuccessful outcomes. In contrast, Lactobacillus consistently enriched birth Conclusions Our findings indicate that useful biomarker predict outcome, offering an opportunity further improve diagnosis treatment strategies.
Язык: Английский
Процитировано
194
Fertility and Sterility, Год журнала: 2020, Номер 115(1), С. 45 - 53
Опубликована: Окт. 16, 2020
Процитировано
144
Biomolecules, Год журнала: 2020, Номер 10(4), С. 593 - 593
Опубликована: Апрель 11, 2020
Current knowledge suggests that the uterus harbours its own microbiota, where microbes could influence uterine functions in health and disease; however, core microbial composition host-microbial relationships remain to be fully elucidated. Different studies are indicating, based on next-generation sequencing techniques, dysbiosis associated with several gynaecological disorders, such as endometriosis, chronic endometritis, dysfunctional menstrual bleeding, endometrial cancer, infertility. Treatments using antibiotics probiotics and/or prebiotics for being applied. Nevertheless there is no unified protocol assessing optimal treatment established dysbiosis. With this review we outline (mostly bacteria) identified microbiome studies, current treatments offered bacterial clinical setting, future possibilities pro- transplants modifying composition.
Язык: Английский
Процитировано
140
Fertility and Sterility, Год журнала: 2021, Номер 115(3), С. 546 - 560
Опубликована: Фев. 11, 2021
Язык: Английский
Процитировано
133
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(1), С. 485 - 485
Опубликована: Янв. 1, 2022
Changes in the female genital tract microbiome are consistently correlated to gynecological and obstetrical pathologies, dysbiosis can impact reproductive outcomes during fertility treatment. Nonetheless, a consensus regarding physiological core inside uterine cavity has not been reached due myriad of study limitations, such as sample size experimental design variations, influence endometrial bacterial communities on human reproduction remains debated. Understanding healthy microbiota how changes its composition affect would potentially allow personalized treatment through management assisted therapies, ultimately leading improvement clinical outcomes. Here, we review current knowledge it relates conception.
Язык: Английский
Процитировано
80
JBRA, Год журнала: 2022, Номер unknown
Опубликована: Янв. 1, 2022
Endometritis is defined as an infection or inflammation of the endometrium.Endometritis two types: acute and chronic.Acute endometritis symptomatic endometrium, which upon examination with a microscope shows micro-abscess neutrophil invasion in superficial endometrium.One its most common manifestations postpartum endometritis.Chronic silent disease usually diagnosed on workup secondary amenorrhoea infertility.An important cause chronic tuberculosis, especially developing nations.Chronic have been associated poor reproductive outcomes.Worse outcomes reported for individuals endometritis.This scoping review impact fertility.
Язык: Английский
Процитировано
70
Reproductive Medicine and Biology, Год журнала: 2018, Номер 18(1), С. 40 - 50
Опубликована: Ноя. 1, 2018
Abstract Background The female reproductive tract contains an active microbiome comprising mainly bacteria from the Lactobacillus genus, which is associated with a healthy state. However, spatio‐temporal fluctuations of this that occur in response to internal and external factors may impact physiology organs even lead pathological states. Methods Current literature covering summarized contextualized review. Main findings This review presents current knowledge about bacterial composition lower upper as well microbiota on women's health reproduction. We place special focus endometrial infertility assisted technologies. Conclusion assessment adds new microbiological perspective human reproduction, pregnancy, onset life, highlighting importance considering evaluation microbial communities improve personalized care medicine health.
Язык: Английский
Процитировано
123
Fertility and Sterility, Год журнала: 2019, Номер 112(1), С. 162 - 173.e2
Опубликована: Май 16, 2019
Язык: Английский
Процитировано
99
Mediators of Inflammation, Год журнала: 2019, Номер 2019, С. 1 - 10
Опубликована: Май 21, 2019
Studies suggest that persisting intrauterine bacterial infectious conditions such as chronic endometritis potentially impair the embryo implantation process. The microbial environment in female reproductive tract, however, remains largely undetermined infertile patients with a history of repeated failure (RIF). Using next-generation sequencing, we aimed to characterize microbiota endometrial fluid (EF) and vaginal secretions (VS) women RIF. Twenty-eight RIF eighteen undergoing first vitro fertilization-embryo transfer attempt (the control group) were enrolled study. On days 6-8 luteal phase natural, oocyte-pickup, or hormone replacement cycle, paired EF VS samples obtained separately. Extracted genomic DNA was pyrosequenced for V4 region 16S ribosomal RNA using sequencer. had higher α -diversity broader species than both groups. analysis UniFrac distance matrices between also revealed significantly different clustering. Additionally, microbiota, but not showed significant variation community composition group group. Burkholderia detected any detectable quarter To our best knowledge, this is study investigating
Язык: Английский
Процитировано
95