Effects of Obesity on Female Fertility: Mechanisms, Clinical Consequences and Management Strategies

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(03), С. 1646 - 1653

Опубликована: Янв. 1, 2025

Язык: Английский

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Factors affecting the postoperative survival rate of obese Asian patients with endometrial cancer

Journal of Obstetrics and Gynaecology, Год журнала: 2025, Номер 45(1)

Опубликована: Март 26, 2025

The objective of this study was to explore the factors that influence overall survival in obese patients with endometrial cancer (EC). retrospective included EC who were treated between 2000 and April 2013. Subjects divided into following groups based on body mass index (BMI): non-obese (<24.0 kg/m2), overweight (24.0-28.0 kg/m2) (>28.0 kg/m2). Survival data estimated using Kaplan-Meier's curves compared log-rank statistics. A total 280 cases enrolled, including 22.5% group, 42.9% group 34.6% group. Among different BMI groups, diabetes have a lower rate (p = .041), menopause .021). significantly reduced if vascular thrombus lymph node metastasis found during operation < .001). Our suggest association menstrual status, intraoperative vasculature embolus affects postoperative survival. In all subjects, relevant independent prognostic obese.

Язык: Английский

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Formin INF2 supplementation alleviates cytoskeleton-based mitochondria defects for oocyte quality under obesity

Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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A Multidisciplinary Approach to Weight Management and Reproductive Care: A Retrospective Cohort Study on Weight Loss through Personalized and Patient-Centered Care

Опубликована: Апрель 14, 2025

Background Obesity is a highly prevalent chronic disease with significant and complex impact on reproduction. National guidelines recommend weight loss prior to pregnancy for patients obesity mitigate complications increase fertility; however, targeted, personalized interventions are limited. The objectives of this study describe the implementation multidisciplinary program designed specifically women reproductive disorders report differences in baseline characteristics outcomes between willing vs not defer attempts focus loss.Methods Retrospective cohort at university obesity. All participants from initiation (November 2021) through July 2023 were included analysis. Primary outcome was percent body 3 months. Secondary 6 months achievement > 5% 10% each time point.Results A total 237 majority (88.2%) desired pregnancy. 63.2% who postpone attempts/fertility treatments so that they could least Participants achieved significantly greater compared those continued (mean − 4.8% -2.5%, p = 0.004) more likely achieve (14.0% 2.20%, 0.031). Those by within first trying conceive (34.1% 7.7%, 0.004).Conclusions We development seeking management. An individualized approach management care results clinically especially among months.Trial Registration: Clinical trial number: applicable.

Язык: Английский

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When Weight Matters: How Obesity Impacts Reproductive Health and Pregnancy-A Systematic Review

Current Obesity Reports, Год журнала: 2025, Номер 14(1)

Опубликована: Апрель 16, 2025

Abstract Purpose of Review This systematic review evaluates the impact obesity on both male and female reproductive health, assisted technology (ART) outcomes, pregnancy-related complications, providing a comprehensive synthesis evidence. Recent Findings Obesity is critical factor adversely affecting ART success rates, pregnancy outcomes. studies indicate hormonal disruptions, metabolic syndrome, epigenetic modifications as central mechanisms linking to infertility adverse results. Summary A search adhering Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines included 35 studies, focusing obesity-related The highlights that disrupts balance, including reductions in sex hormone-binding globulin (SHBG) testosterone levels, alongside increased insulin resistance chronic inflammation. These impair ovarian function, endometrial receptivity, sperm quality, resulting prolonged time-to-pregnancy (TTP), reduced miscarriage risk. During pregnancy, maternal elevates risks gestational diabetes mellitus (GDM), preeclampsia, cesarean delivery while contributing neonatal such macrosomia intensive care unit (NICU) admissions. findings emphasize dual paternal offspring particularly through leading intergenerational dysfunction. underscores necessity preconception weight management, individualized protocols, tailored antenatal mitigate obesity’s effects Future research should focus understanding mechanisms, optimizing interventions individuals with obesity, conducting longitudinal impacts health. provides actionable insights guide clinical practices future investigations.

Язык: Английский

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Association between a body shape index and female infertility: a cross-sectional study

BMC Women s Health, Год журнала: 2024, Номер 24(1)

Опубликована: Сен. 4, 2024

Язык: Английский

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Precision Interventions Targeting the Maternal Metabolic Milieu for Healthy Pregnancies in Obesity

Current Diabetes Reports, Год журнала: 2024, Номер 24(10), С. 227 - 235

Опубликована: Авг. 20, 2024

Язык: Английский

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The Interplay of Uterine Health and Obesity: A Comprehensive Review

Biomedicines, Год журнала: 2024, Номер 12(12), С. 2801 - 2801

Опубликована: Дек. 10, 2024

Uterine physiology encompasses the intricate processes governing structure, function, and regulation of uterus, a pivotal organ within female reproductive system. The escalating prevalence obesity has emerged as significant global health issue, profoundly impacting various facets well-being, including health. These effects extend to uterine structure influencing outcomes in women. They encompass alterations morphology, disruptions hormonal signaling, inflammatory processes. Insulin leptin, hormones regulating metabolism, energy balance, play crucial roles this context. chiefly governs glucose metabolism storage, while leptin regulates appetite expenditure. However, obesity, resistance both insulin can develop, function. Inflammation oxidative stress further exacerbate development dysfunction obesity. Chronic low-grade inflammation heightened stress, characteristic contribute metabolic tissue damage, uterus. Obesity significantly disrupts menstrual cycles, fertility, pregnancy accumulation excess adipose equilibrium, disturbs ovarian fosters irregularities, all which detrimentally impact

Язык: Английский

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Impact of psychological stress on ovarian function: Insights, mechanisms and intervention strategies (Review)

International Journal of Molecular Medicine, Год журнала: 2024, Номер 55(2)

Опубликована: Дек. 18, 2024

Mental stress may lead to ovarian dysfunction. Psychological disrupts function, leading adverse in vitro fertilization outcomes, premature insufficiency and decreased reserve. Furthermore, psychological caused by function infertility can exacerbate the mental burden. In animals, leads insufficiency, resulting in irregular estrous cycles The present study summarizes effects of psychogenic on underlying mechanisms, highlighting involvement hypothalamic‑pituitary‑adrenal, sympathetic‑adrenal‑medullary hypothalamic‑pituitary‑ovarian axes, as well neuroendocrine‑metabolic network. Moreover, review outlines intervention metabolic strategies for improving offering potential new approaches treating hypofunction. aims clarify understanding stress‑induced dysfunction propose alternative infertility.

Язык: Английский

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Reproductive toxicology: keeping up with our changing world

Frontiers in Toxicology, Год журнала: 2024, Номер 6

Опубликована: Окт. 11, 2024

Reproductive toxicology testing is essential to safeguard public health of current and future generations. Traditional toxicological male reproduction has focused on evaluating substances for acute toxicity the reproductive system, with fertility assessment as a main endpoint infertility adverse outcome. Newer studies in last few decades have significantly widened our understanding what represents an event toxicology, thus changed perspective constitutes toxicant, such endocrine disrupting chemicals that affect offspring intergenerational manner. Besides or congenital abnormalities, outcomes can present increased likelihood various problems offspring, including metabolic syndrome, neurodevelopmental like autism cancer predisposition, among others. To enable toxicologic accurately represent population, designs need model changing population characteristics exposure circumstances. Current trends increasing importance human include paternal age, associated decline nicotinamide adenine dinucleotide (NAD), higher prevalence obesity, both which are factors study design should account for. In this article, we highlighted some limitations standard protocols, expanding assessed by genetic epigenetic sperm parameters, potential recent developments, mixture testing, novel animal models, vitro systems organoids, multigenerational well silico modelling, machine learning artificial intelligence.

Язык: Английский

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