Critical appraisal and narrative review of the literature in IVF/ICSI patients with adenomyosis and endometriosis DOI Creative Commons
Ramazan Mercan, Can Benlioğlu, Gülümser Ece AKSAKAL

и другие.

Frontiers in Reproductive Health, Год журнала: 2024, Номер 6

Опубликована: Дек. 24, 2024

Endometriosis and adenomyosis are prevalent causes of infertility, often coexisting in a significant proportion patients. Although endometriosis typically does not negatively impact assisted reproductive technology (ART) outcomes, the presence adenomyosis, mainly non-severe external forms, may slightly influence IVF/ICSI success rates. However, this is minimal result insignificant changes statistical analyses. Recent studies underscore critical role accurate diagnostic techniques, such as ultrasound or MRI, identifying severe characteristics, including diffuse involvement with junctional zone participation. This precise delineation reassuring, it essential for tailoring strategies to enhance rates reduce confounding effects particularly when coexists endometriosis. Strategic approaches, ultralong GnRH agonist protocols freeze-all strategies, provide advantages these scenarios. need extensive research vital understanding complex interactions between endometriosis, ART outcomes. ongoing exploration important cases where might significantly results.

Язык: Английский

Endometriosis and autoimmunity DOI

Luz P. Blanco,

Noemi Salmeri, Sarah M. Temkin

и другие.

Autoimmunity Reviews, Год журнала: 2025, Номер unknown, С. 103752 - 103752

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Scientific landscape and visualization analysis of the link between adenomyosis and infertility from 2000 to 2024 DOI Creative Commons

Qiaomei Yang,

Xinye Zheng,

Fuchun Zhong

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Фев. 19, 2025

Adenomyosis (AM) is a chronic disorder that significantly impacts women's health and quality of life worldwide, particularly by causing progressive impairment in fertility. This study aimed to summarize visualize the literature concerning AM-associated infertility using scientometric analysis. We conducted search Web Science™ Core Collection (WoSCC) database for "adenomyosis" "infertility" as topics from 2000 2024. The collected data were organized Microsoft Office Excel further Bibliometric analyses visualizations performed Origin, CiteSpace, VOSviewer, Bibliometrix package. A total 456 articles published across 153 journals, reflecting growing trend both cited articles. scholars with highest output Petraglia F., Chapron C., Pellicer A., while Fertility Sterility most publications' journal. China, United States, Italy ranked top three countries globally regarding relevant publications worldwide. 190 keywords divided into eight clusters primarily related pathogenesis, adverse factors affecting pregnancy, treatment methods, diagnostic disease progression, vitro fertilization (IVF) management, women, fertility management. Current hotspots this field include investigating potential mechanisms strategies, improving pregnancy outcomes patients infertility. highlights significant complex issue associated AM. Although management pharmacological treatments, assisted reproductive technologies (ART) have improved women AM, clinical translational research still warranted.

Язык: Английский

Процитировано

0
Causal Effect Between Natural Hair Color and Endometriosis in a European Population: A Two-Sample Mendelian Randomization DOI
Yuping Zhang, Ying Feng

Twin Research and Human Genetics, Год журнала: 2025, Номер unknown, С. 1 - 11

Опубликована: Фев. 25, 2025

Abstract Previous observational studies have suggested an association between natural hair color and the risk of endometriosis; however, causal relationship remains unclear. Here, we conducted a two-sample Mendelian randomization (MR) study to evaluate potential link endometriosis using 428 single nucleotide polymorphisms (SNPs) as genetic instruments derived from genomewide meta-analysis comprising over 4511 cases 227,260 controls European ancestry. Our findings indicate that dark brown is associated with decreased developing (dark IVW OR : 0.844, 95% CI [0.725, 0.984], p < .05). Conversely, lighter colors (red, blonde, light brown) did not demonstrate significant 0.568, [0.280, 1.15], = .117; red 1.058, [0.719, 1.558], .77; blonde OR: 1.158, [0.886, 1.514], .28; 1.306, [0.978, 1.743], .07). These results provide compelling MR evidence supporting risk. underscore need for larger scale randomized controlled trials delineate biological mechanisms driving endometriosis.

Язык: Английский

Процитировано

0
Prevalence of endometriosis in Mayer–Rokitansky–Küster–Hauser syndrome variants: a systematic review and meta-analysis DOI Creative Commons
Paolo Vercellini, Francesca Caprara, Martina Piccini

и другие.

Human Reproduction, Год журнала: 2025, Номер unknown

Опубликована: Март 23, 2025

In patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS; population), is the presence of functional endometrium (FE) in uterine remnants (URs) (exposure), compared absence FE UR/absence UR (comparison), associated a higher prevalence endometriosis (outcome)? The aggregate was considerably MRKHS (MRKHSFE+) than those without (MRKHSFE-). pathogenesis not fully understood. finding pelvic one main objections to retrograde menstruation (RM) hypothesis. recent advent high-resolution ultrasonography and magnetic resonance imaging (MRI) allowed reliable preoperative identification concealed within UR, histopathological examination after removal no longer only means verifying mucosal component. A similar MRKHSFE+ MRKHSFE- patients, as assessed by ultrasound (US) and/or MRI, would essentially rule out RM/implantation theory, whereas substantially challenge embryonic remnants/coelomic metaplasia This systematic review restricted full-length, English-language articles published peer-reviewed journals between 1 January 1980 June 2024. electronic PubMed Embase databases were searched keyword 'endometriosis' used combination 'Mayer-Rokitansky-Küster-Hauser syndrome', 'Müllerian agenesis', 'uterine 'vaginal anomalies', 'female genital malformations'. References from relevant publications screened, PubMed's 'similar articles' 'cited by' functions used. Studies selected if they reported or investigated US MRI histology surgical removal, surgically confirmed endometriosis. Case series case reports deemed eligible for inclusion. specifically stating intent search reporting results histological examinations excluded. Two reviewers independently abstracted data. risk bias using tool devised ascertain methodological quality reports. total 102 studies (29 73 reports), comprising 666 whom verified included. Endometriosis detected 71 participants (10.7%; 95% CI, 8.5-13.2%), its 8.6% (51/593; 6.6-11.2%) 27.4% (20/73; 18.4-38.6%) (P<0.0001). When considering 19 ≥10 participants, proportion 3.4% (41/1219; 2.5-4.5%). Among endometriosis, 64 had coexisting FE, seven evidence did have UR. 32.0% subgroup (64/200; 25.9-38.8%) 1.5% (7/466; 0.7-3.1%) UR/without At meta-analysis series, overall estimates were, respectively, 16.8% (95% 1.8-38.5%) 0% 0-0%). order evaluate association we also conducted that included both FE+ FE- patients. significantly increased observed (overall odds ratio estimate 12.0; 5.1-28.3%). score (median score, 4 points; interquartile range, 3-5 points) 3 2-4 points). Due uncontrolled non-experimental study design, are an selection, performance, detection, attrition, bias. cases purportedly systematically performed erroneous findings reported, anatomical description at surgery incomplete inconsistent, diagnosis missing questionable, precise microscopic features always described. Whether (exposure) truly absent all these whether lesions diagnosed (outcome) indeed true disease, seems uncertain. Our should raise awareness importance accurately assessing performing biopsies visually Considering high bias, detection allegedly few last four decades be interpreted tout court proof coelomic metaplasia/embryonic theory. No funding received this review. P.Ve. member Editorial Board Human Reproduction Open, Journal Obstetrics Gynaecology Canada, International Acta Obstetricia et Gynecologica Scandinavica; has royalties Wolters Kluwer chapters on management clinical decision support resource UpToDate; maintains public private gynaecological practice. E.S. Editor-in-Chief Open; discloses payments Ferring research grants honoraria Merck-Serono lectures; P.Vi. Co-Editor-in-Chief Uterine Disorders. All other authors declare conflict interest. protocol registered PROSPERO (registration number, CRD42024512351).

Язык: Английский

Процитировано

0
Potential anatomical determinants of retrograde menstruation: a comprehensive narrative review DOI
Paolo Vercellini, Martina Piccini, Francesca Caprara

и другие.

Reproductive BioMedicine Online, Год журнала: 2024, Номер 49(4), С. 104345 - 104345

Опубликована: Июнь 21, 2024

Язык: Английский

Процитировано

1
From Diagnosis to Fertility: Optimizing Treatment of Adenomyosis for Reproductive Health DOI Open Access
Hanna Kim, Emily H. Frisch, Tommaso Falcone

и другие.

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(16), С. 4926 - 4926

Опубликована: Авг. 21, 2024

Adenomyosis is a benign gynecologic disorder that had previously not been well studied or understood. However, it now become more common diagnosis with long-standing implications especially for fertility. In this literature review, the pathophysiology and along management options uterine preservation fertility definitive are reviewed. While there better understanding of adenomyosis, still research needed to fully elucidate best ways patients in those seeking

Язык: Английский

Процитировано

1
Effects of pretreatment strategies on fertility outcomes in patients with adenomyosis DOI Creative Commons
Gaby Moawad, Youssef Youssef, Arrigo Fruscalzo

и другие.

Frontiers in Reproductive Health, Год журнала: 2024, Номер 6

Опубликована: Дек. 9, 2024

Adenomyosis is a commonly encountered pathology in women of reproductive age and frequently coexists with infertility. The effect adenomyosis on fertility, particularly

Язык: Английский

Процитировано

1
Critical appraisal and narrative review of the literature in IVF/ICSI patients with adenomyosis and endometriosis DOI Creative Commons
Ramazan Mercan, Can Benlioğlu, Gülümser Ece AKSAKAL

и другие.

Frontiers in Reproductive Health, Год журнала: 2024, Номер 6

Опубликована: Дек. 24, 2024

Endometriosis and adenomyosis are prevalent causes of infertility, often coexisting in a significant proportion patients. Although endometriosis typically does not negatively impact assisted reproductive technology (ART) outcomes, the presence adenomyosis, mainly non-severe external forms, may slightly influence IVF/ICSI success rates. However, this is minimal result insignificant changes statistical analyses. Recent studies underscore critical role accurate diagnostic techniques, such as ultrasound or MRI, identifying severe characteristics, including diffuse involvement with junctional zone participation. This precise delineation reassuring, it essential for tailoring strategies to enhance rates reduce confounding effects particularly when coexists endometriosis. Strategic approaches, ultralong GnRH agonist protocols freeze-all strategies, provide advantages these scenarios. need extensive research vital understanding complex interactions between endometriosis, ART outcomes. ongoing exploration important cases where might significantly results.

Язык: Английский

Процитировано

0