Origanum syriacum oil-loaded carboxymethyl chitosan polyelectrolyte nanoparticles: Box–Behnken design optimization of nano-encapsulation, physicochemical, and therapeutic properties

Polymer Bulletin, Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Язык: Английский

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Plant secondary metabolites-mediated plant defense against bacteria and fungi pathogens

Plant Physiology and Biochemistry, Год журнала: 2024, Номер 217, С. 109224 - 109224

Опубликована: Окт. 20, 2024

Язык: Английский

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Aromatic Herbs as a Source of Bioactive Compounds: An Overview of Their Antioxidant Capacity, Antimicrobial Activity, and Major Applications

Molecules, Год журнала: 2025, Номер 30(6), С. 1304 - 1304

Опубликована: Март 14, 2025

Many aromatic herbs are conventionally used for flavoring various foods, but receive wide attention because of the variety health-related properties. The can be either fresh or as dried powders and in form extracts, essential oils, purified metabolites. In this review, main functional properties, terms antioxidant antimicrobial applications some commonly from Lamiaceae family, discussed. Herbs like oregano, rosemary, sage, thyme, summer savory, marjoram, basil possess high levels bioactive phytochemicals. They particularly rich phenolic acids, flavones, diterpenes, flavanones, with beneficial effects. phytochemical profile plants is highly influenced by genetic factors, environmental conditions, their interaction. cases extracts extraction method has a strong effect on final composition herb products. Most these related to antioxidant, antimicrobial, particular, oils have multiple fields food, feed, pharmaceutical, cosmetics, biopesticides, textile industries.

Язык: Английский

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Pharmacokinetics and Toxicity Study of a Single Intravenous Dose of Distilled Extract of Zanthoxylum piperitum in ICR Mice

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

This study aimed to investigate the pharmacokinetics and acute toxicity of a single intravenous dose distilled Zanthoxylum piperitum (deZP) extract in ICR mice. The focus was on understanding absorption, distribution, elimination Terpinen-4-ol, major active component deZP, as well assessing its safety at administered dose. mice were deZP (2.4 mg/kg), plasma concentrations Terpinen-4-ol measured using LC-MS/MS various time points. Pharmacokinetic parameters such Cmax, Tmax, half-life, clearance rate calculated. In addition, clinical signs, mortality, biochemical markers monitored evaluate toxicity. rapidly absorbed, reaching peak concentration (Cmax) 609.0 ng/mL within 0.083 hours (Tmax). It exhibited short half-life 0.168 high 194.1 L/h/kg. No mortality or significant signs observed. Biochemical parameters, including liver kidney function markers, remained normal ranges, indicating that well-tolerated. pharmacokinetic profile suggests rapid absorption while assessment indicates good tolerability tested These findings provide foundation for further exploration deZP's therapeutic potential.

Язык: Английский

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Anti-Hyperalgesic Effect of Isopulegol Involves GABA and NMDA Receptors in a Paclitaxel-Induced Neuropathic Pain Model

Pharmaceuticals, Год журнала: 2025, Номер 18(2), С. 256 - 256

Опубликована: Фев. 14, 2025

Background: Neuropathic pain can be triggered by chemotherapy drugs such as paclitaxel (PTX). Management of is limited drugs' ineffectiveness and adverse effects. Isopulegol (ISO) a monoterpene present in the essential oils several aromatic plants has promising pharmacological activities. Objectives: to evaluate antinociceptive activity ISO PTX-induced neuropathic model. Methods: toxicity was evaluated healthy cancerous cells. Behavioral assessments were performed using von Frey acetone tests. We investigated involvement GABAergic pathway, NMDA, TNF-α, release GABA glutamate presence ISO. Results: showed little or no cytotoxicity U87 MDA-MB-231 In both acute subacute treatment, at doses 25, 50, 100 mg/kg (* p < 0.05) increased mechanical nociceptive threshold animals compared control group reduced thermal sensitivity. Its action reversed pre-treatment with flumazenil potentiated NMDA antagonist, MK-801. TNF-α levels tests carried out. Conclusions: shows low neuronal cells its association PTX generated synergism cytotoxic action. The effect due activation antagonism receptors involves stabilization plasma membranes leading an imbalance neurotransmitters, favoring GABA-mediated inhibition over glutamatergic excitation.

Язык: Английский

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Changes in volatile flavor compounds and metabolites during processing of ginger milk curd from buffalo milk by GC-IMS and LC-MS

Food Research International, Год журнала: 2025, Номер 209, С. 116230 - 116230

Опубликована: Март 17, 2025

Язык: Английский

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An Overview of the Chemical Compositions and Biological Activities of Essential Oils from Selected Zingiber Species (Zingiberaceae)

Natural Product Communications, Год журнала: 2025, Номер 20(3)

Опубликована: Март 1, 2025

Zingiber Mill. is the second-largest genus of Zingiberaceae family. The members this are known for their diverse applications in food, cosmetics, pharmaceuticals, and healthcare fields due to richness bioactive components found essential oils (EOs). This study aims provide information about EOs’ chemical composition biological activities from 23 species. A literature survey was performed via scientific databases, including PubMed, Scopus, Web Science, Google Scholar, ethnobotanical textbooks. Clustering analysis conducted using Unweighted Pair Group Method with Arithmetic Mean (UPGMA) construct phylogenetic trees. Various studies have revealed that β -pinene, α -caryophyllene, -elemene, bicyclogermacrene, sabinene, camphene, linalool, ( E )-nerolidol, terpinen-4-ol, 1,8-cineole, humulane-1,6-dien-3-ol, -phellandrene, zerumbone representative ingredients EOs. Pharmacologically, current results recorded several species related antioxidant Z. plicatum ), antimicrobial rubens , castaneum nitens tamii magang densissimum cornubracteatum nudicarpum ottensii recurvatum vuquangense eberhardtii skornickovae anti-larvicidal mekongense neotruncatum collinsii antidiabetic atroporphyreus anticancer cytotoxic ) properties. Cluster showed had highest phytochemical similarity, followed by . Additionally, dendrogram offers crucial insights into relationships among species, highlighting similarities between leaves, stems, rhizomes, roots, inflorescences, fruits. first report highlight recent bioactivity assessments summarize EO different parts promising modern medicine.

Язык: Английский

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Biological Activities of Essential Oils and Hydrolates from Different Parts of Croatian Sea Fennel (Crithmum maritimum L.)

Biomolecules, Год журнала: 2025, Номер 15(5), С. 666 - 666

Опубликована: Май 4, 2025

The traditional nutritional use of sea fennel (Crithmum maritimum L.) has been rediscovered and reestablished, making this halophyte plant a prominent ingredient in coastal cuisine subject interest various scientific disciplines, including pharmacy medicine. first objective study was to identify the volatile profiles essential oils (EOs) hydrolates derived from leaves, flowers, fruits using gas chromatography–mass spectrometry. A total 25 different volatiles were identified EOs 63 hydrolates. Limonene most abundant component (74.85%, 74.30%, 67.41%, respectively), while hydrolates, it terpinen-4-ol leaves (27.8%) flowers (36.7%) (Z)-carveol (11.4%). second investigate biological activities samples. antioxidant choline inhibitory generally low, with flower hydrolate providing inhibition both enzymes leaf highest antiradical activity. cytotoxic also investigated. human breast adenocarcinoma cell line MDA-MB-23 sensitive against fruits, reaching IC50 after 48 72 h, respectively. exhibited activity effective h. MCF-7 fruit EOs, reached at all tested periods. Overall, results highlight as rich source bioactive compounds that have significant potential for greater utilization nutraceutical pharmaceutical industries.

Язык: Английский

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Improving Ancha tea aroma quality via innovative processing: Characterization of key odorants by GC–MS, GC-O, Sensomics, and Chemometrics

Food Chemistry, Год журнала: 2025, Номер 486, С. 144681 - 144681

Опубликована: Май 9, 2025

Язык: Английский

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Decoding the Secrets of Odor‐Active Compounds in Dark Tea

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2025, Номер 24(3)

Опубликована: Май 1, 2025

ABSTRACT Dark tea has received growing attention in recent years due to its distinctive aroma and potential health benefits. The overall profile of dark is determined by the combined effects diverse odor‐active compounds (OACs). However, comprehensive studies on these remain limited. Beyond role sensory perception, could also exert physiological functions? Existing research primarily focused benefits non‐volatile components tea, such as polyphenols, polysaccharides, theanine. OACs influence processes via olfactory receptors (ORs) remains underexplored literature. Accordingly, we systematically classify comprehensively review OACs. Furthermore, examine OAC–OR interactions, encompassing not only their roles recognition emotion regulation nasal ORs but therapeutic applications mediated non‐nasal ORs. Interestingly, our findings reveal that follow a “structure‐similarity–function‐convergence” trend both bioactivity aromatic properties. Specifically, structurally similar impart analogous profiles may share comparable functions. This phenomenon provides new insights into flavor compounds. enhances understanding systematically, for first time, explores health‐related functions interactions between It offers future integrative food shed light synergistic odor bioactive regulation.

Язык: Английский

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