Comprehensive Quality Evaluation of Traditional Chinese Medicine Guanxinjing Capsule Based on Fingerprint and Multicomponent Simultaneous Quantitative Method
Journal of Separation Science,
Год журнала:
2025,
Номер
48(1)
Опубликована: Янв. 1, 2025
ABSTRACT
A
novel
dual‐wavelength
ultrahigh
performance
liquid
chromatography
(UHPLC)
fingerprint
was
established,
56
common
peaks
were
confirmed
and
attributed
to
the
source
of
medicinal
materials,
13
chromatographic
them
identified
by
UHPLC
quadrupole
time‐of‐flight
(Q‐TOF)‐MS/MS
UHPLC‐UV
method.
Furthermore,
a
simple
sensitive
HPLC‐quadrupole
trap
(Q‐TRAP)‐MS/MS
developed
for
simultaneous
determination
16
active
components
with
electrospray
ionization
(ESI)
switching
between
positive
negative
modes
in
single
run.
The
above
two
methods
successfully
applied
quality
evaluation
Guanxinjing
capsule
(GXJC).
Finally,
statistical
analysis
including
principal
component
(PCA),
hierarchical
cluster
(HCA),
orthogonal
partial
least
squares
discriminate
(OPLS‐DA)
applied,
variables
great
contribution
different
groups
samples
screened.
This
study
not
only
provides
rapid,
accurate,
comprehensive
qualitative
quantitative
method
GXJC
but
it
also
reference
workflow
other
traditional
Chinese
medicines.
Язык: Английский
Ultrasound-assisted extraction, optimization, and purification of total flavonoids from Daphnegenkwa and analysis of their antioxidant, anti-inflammatory, and analgesic activities
Ultrasonics Sonochemistry,
Год журнала:
2024,
Номер
111, С. 107079 - 107079
Опубликована: Сен. 23, 2024
Язык: Английский