Journal of Drug Delivery and Therapeutics,
Год журнала:
2025,
Номер
15(4), С. 126 - 132
Опубликована: Апрель 15, 2025
Medicinal
plants
are
an
integral
part
of
the
healthcare
system
in
Africa.
In
traditional
medicine,
a
mixture
Ipomoea
batatas
leaves
and
Milicia
excelsa
roots
is
used
to
treat
cancer,
mostly
breast
colon
cancer.
It
can
be
on
its
own
or
with
other
common
cancer
treatments.
While
popular
belief
assumes
that
medicinal
plants,
being
natural,
healthier
than
conventional
medicines,
scientific
studies
have
shown
induce
serious
adverse
effects
influence
patient's
prognosis.
order
regulate
use,
literature
review
information
available
composition,
toxicity
anti-cancer
properties
decoction
was
carried
out
December
2024.
To
date,
there
no
publications
anticancer
activity
extracts
roots.
However,
excelsa,
taken
separately,
very
rich
secondary
metabolites
which
been
effective
against
several
types
terms
toxicity,
best
tolerated
at
doses
10
100
mg/kg.
The
not
subject
repeated-dose
studies.
This
revealed
lack
data,
particularly
safety,
prevented
formulation
recommendations
concerning
use.
find
more
about
safety
effectiveness
using
research
needs
done.
Keywords:
Anticancer
activity,
batatas,
excelsa.
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 8, 2024
Abstract
This
study
evaluates
the
pharmacological
effects
of
iridoid
glucoside
loganic
acid,
a
plant
constituent
with
diverse
properties,
based
on
literature,
and
explores
underlying
cellular
mechanisms
for
treating
several
ailments.
Data
were
collected
from
reliable
electronic
databases,
including
PubMed,
Scopus,
Web
Science,
Google
Scholar,
etc.
The
results
demonstrated
anti‐inflammatory,
anti‐oxidant,
other
protective
acid
metabolic
diseases
disorders
such
as
atherosclerosis,
diabetes,
obesity,
in
addition
to
its
osteoprotective
anticancer
properties.
antioxidant
activity
demonstrates
capacity
protect
cells
oxidative
damage
mitigates
inflammation
by
reducing
inflammatory
cytokines
involving
TNF‐α
IL‐6,
substantially
upregulating
expression
PPAR‐γ/α,
decreasing
clinical
signs
inflammation‐related
conditions
related
hypertriglyceridemia
atherosclerosis.
Meanwhile,
inhibits
bone
loss,
exhibits
properties
increasing
mRNA
levels
synthesizing
genes
Alpl,
Bglap,
Sp7,
significantly
increases
osteoblastic
proliferation
preosteoblast
cells.
Loganic
is
an
anti‐metastatic
drug
that
reduces
MnSOD
expression,
EMT
metastasis,
prevents
migration,
proliferation,
invasion
hepatocellular
carcinoma
However,
additional
trials
are
required
assess
safety,
efficacy,
human
dose.
International Journal of Science and Research Archive,
Год журнала:
2024,
Номер
11(1), С. 2502 - 2539
Опубликована: Фев. 28, 2024
This
review
paper
has
highlighted
a
list
of
plants
containing
active
phytochemicals
with
anticancer
potential,
as
well
data
supporting
their
use
in
cancer
therapy,
animal
models,
and
pharmacological
properties.
Cancer
is
among
the
leading
causes
morbidity
mortality
worldwide.
disease
characterized
by
abnormal
cell
division
proliferation
that
result
from
disruption
molecular
signals
control
these
processes.
abnormal,
uncontrolled
cells
body.
The
when
malignant,
invade
various
parts
body
through
bloodstream.
spread
its
or
tissue
origin
to
another
healthy
part
tissues
organs
called
metastasis.
Some
regular
characteristics
cancers
are
apoptosis,
angiogenesis,
multiple
replication,
growth
signal
production,
insensitivity
anti-growth
These
features
make
have
continuous
growth,
long
time
survival
potential
normal
cells.
Moreover,
if
activities
not
blocked,
will
continue
increase,
overwhelm
finally
kill
patient
cancer.
Oncology
study
An
oncologist
doctor
who
treats
provides
medical
care
for
person
diagnosed
may
also
be
specialist.
Today,
despite
considerable
efforts,
still
remains
an
aggressive
killer
success
rate
therapies
diminished
toxicities,
drug
resistance,
recurrence
treatment
failure.
A
significant
challenge
associated
much
art
it
science.
Therefore,
there
constant
demand
develop
new,
effective,
affordable
drugs.
Several
factors,
such
environmental
habitual
activities,
genetic
etc.,
responsible
Many
patients
seek
alternative
and/or
complementary
treatments
because
high
death
linked
adverse
side
effects
chemotherapy,
radiation
immunotherapy,
surgery,
stem
therapy.
Medicinal
could
possess
effective
compounds
used
adjuvants
existing
chemotherapy
improve
efficacy
reduce
drug-induced
toxicity;
chemotherapy-induced
nausea
vomiting
patients’
quality
life.
Cell
caused
whole
plant
extracts
via
apoptosis.
However,
majority
been
researched
prevention
rather
than
treatment,
resulting
low
uptake
practice.
Prevention
certainly
attractive
management
strategy.
Thus
might
possible
process
carcinogenesis
along
lifestyle.
ACS Omega,
Год журнала:
2024,
Номер
9(10), С. 11200 - 11216
Опубликована: Фев. 29, 2024
Medicinally
valuable
components
derived
from
natural
resources
are
highly
desirable
as
prospective
alternatives
to
synthetic
drugs
treat
fatal
diseases,
such
cancer
and
diabetes
mellitus.
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(5), С. 3150 - 3163
Опубликована: Фев. 20, 2024
Abstract
Polysaccharides
from
non‐conventional
sources,
such
as
fruits,
have
gained
significant
attention
recently.
Aegle
marmelos
(Bael),
a
fruit,
is
an
excellent
source
of
biologically
active
components
with
potential
indigenous
therapeutic
and
food
applications.
Apart
polyphenolic
components,
this
mucilaginous
polysaccharides.
are
one
the
major
bael
having
high
amount
galactose
glucuronic
acid,
which
contributes
to
its
properties.
Therefore,
review
emphasizes
conventional
emerging
techniques
polysaccharide
extraction
fruit.
Insight
into
attributes
their
techno‐functional
properties,
characterization
fruit
polysaccharide,
emulsifying
binding
reduction
hazardous
dyes,
application
polysaccharides
in
film
formation,
nanocomposite,
biological
activities
discussed.
This
also
systematically
overviews
relationship
between
techniques,
structural
characteristics,
activities.
Additionally,
recommendations,
future
perspectives,
new
valuable
insight
towards
better
utilization
been
given
importance,
can
be
promoted
long
term.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Март 1, 2024
A
novel
halotolerant
actinobacterium,
designated
as
RG38
T
,
capable
of
producing
black
extracellular
melanin
pigment
on
SP2
agar,
was
isolated
from
the
roots
Tagetes
patula
.
Comparative
analysis
16S
rRNA
gene
sequence
revealed
highest
similarity
to
Streptomyces
collinus
NBRC
12759
(99.3%).
Phylogenetic
showed
that
strain
clustered
within
genus
forming
a
monophyletic
cluster
with
its
close
relatives.
The
average
nucleotide
identity
(ANI),
digital
DNA–DNA
hybridization
(dDDH),
and
amino-acid
(AAI)
values
between
related
species
were
below
standard
threshold
for
prokaryotic
delineation.
DNA
G
+
C
content
determined
be
73.3%.
genome
size
measured
7,150,598
bp
comprising
17
contigs
encompassed
6,053
protein
coding
genes.
AntiSMASH
whole
35
putative
biosynthetic
clusters
(BGCs)
responsible
various
secondary
metabolites.
Among
these
clusters,
two
exhibited
100%
chromomycin
A3,
albaflavenone,
anthracimycin,
respectively.
These
compounds
reported
possess
significant
anticancer
antibacterial
activities.
LC–MS-based
analysis,
coupled
further
isolation
studies,
confirmed
production
chromomycins
A2
(1),
A3
(2),
their
derivatives,
along
antibiotic
findings
underscore
potential
this
resource
discovery
diverse
antimicrobial
compounds.
This
study
is
first
report
an
compound
medicinal
plant
T.
Based
polyphasic
study,
unexplored
habitat
high
new
natural
products
represents
Accordingly,
we
propose
name
tagetis
sp.
nov.
species,
type
(=KCTC
49624
=
TBRC
15113
).
Applied Sciences,
Год журнала:
2025,
Номер
15(2), С. 925 - 925
Опубликована: Янв. 18, 2025
Clinopodium
vulgare
L.
is
a
valuable
medicinal
plant
with
various
beneficial
effects
on
health.
In
this
study,
water
extracts
from
the
aerial
part
of
wild
and
in
vitro
cultured
C.
plants
were
obtained.
The
polyphenol,
flavonoid
content
antioxidant
activity
as
well
their
antitumor
efficiency
against
panel
cell
lines
analyzed.
ability
to
inhibit
cancer
migration
induce
apoptosis
tumor
cells
was
examined
by
wound
healing
assay
fluorescence
microscopic
methods.
effect
cycle
progression
analyzed
flow
cytometry.
presented
results
show
that
similar
even
exceeded
plants.
viability
assays
demonstrate
selective
anticancer
extract
significant
inhibition
proliferation
motility.
microscopy
analyses
indicate
related
both
antiproliferative
proapoptotic
effects.
These
obtained
micropropagation
cultivated
ex
are
promising
candidates
for
drug
therapy.
