Journal of Drug Delivery and Therapeutics,
Год журнала:
2025,
Номер
15(4), С. 126 - 132
Опубликована: Апрель 15, 2025
Medicinal
plants
are
an
integral
part
of
the
healthcare
system
in
Africa.
In
traditional
medicine,
a
mixture
Ipomoea
batatas
leaves
and
Milicia
excelsa
roots
is
used
to
treat
cancer,
mostly
breast
colon
cancer.
It
can
be
on
its
own
or
with
other
common
cancer
treatments.
While
popular
belief
assumes
that
medicinal
plants,
being
natural,
healthier
than
conventional
medicines,
scientific
studies
have
shown
induce
serious
adverse
effects
influence
patient's
prognosis.
order
regulate
use,
literature
review
information
available
composition,
toxicity
anti-cancer
properties
decoction
was
carried
out
December
2024.
To
date,
there
no
publications
anticancer
activity
extracts
roots.
However,
excelsa,
taken
separately,
very
rich
secondary
metabolites
which
been
effective
against
several
types
terms
toxicity,
best
tolerated
at
doses
10
100
mg/kg.
The
not
subject
repeated-dose
studies.
This
revealed
lack
data,
particularly
safety,
prevented
formulation
recommendations
concerning
use.
find
more
about
safety
effectiveness
using
research
needs
done.
Keywords:
Anticancer
activity,
batatas,
excelsa.
BMC Complementary Medicine and Therapies,
Год журнала:
2025,
Номер
25(1)
Опубликована: Фев. 11, 2025
The
present
study
aimed
to
perform
phytochemical
investigation
of
various
fractions
the
aerial
parts
Senecio
laetus
Edgew
for
its
bio-constitution
and
pharmacologically
evaluate
these
antioxidant
antiproliferative
activities
against
breast
cancer
(MCF-7)
colon
carcinoma
(HCT-116)
cell
lines.
Phytochemical
screening
characterization
compounds
was
carried
out
as
per
standard
procedures.
Extracts
were
subjected
GC-MS
analysis
identification
constituents.
activity
using
DPPH,
ferric
ion
reducing
power
assay,
nitric
oxide
radical
inhibition
assays.
In
vitro
extracts
MCF-7
(breast
cancer)
HCT-116
(colon
carcinoma)
lines
by
MTT
colony
formation
wound
healing
assay.
showed
presence
alkaloids,
flavonoids,
carbohydrates,
glycosides
(cardiac
anthraquinone),
tannins,
triterpenoids,
phenolic
compounds,
phytosterols.
54
compounds.
Ethyl
acetate
methanolic
extract
exhibited
maximum
amount
content
compared
dichloromethane
hexane
fractions.
Antioxidant
capacities
shown
highest
in
ethyl
found
be
concentration
dependent,
with
fraction
more
effective
than
both
results
indicate
that
S.
has
a
promising
potential
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 2645 - 2658
Опубликована: Март 1, 2025
The
potential
use
of
gold
nanoparticles
(AuNPs)
in
healthcare
research
has
increased
dramatically
recent
years,
owing
to
advancements
their
synthesis
techniques,
including
green
synthesis.
Although
Clerodendrum
trichotomum
is
a
popular
medicinal
plant
that
harbors
many
bioactive
phytochemicals
various
parts
the
world,
AuNPs
using
this
precious
still
under
investigation.
Therefore,
study
aimed
explore
from
C.
Thunberg
leaves
(CTT-AuNPs)
and
antibacterial
cytotoxic
properties.
were
synthesized
characterized
microscopic
spectroscopic
techniques.
A
serial
dilution
technique
was
used
determine
activity
CTT-AuNPs
against
two
bacterial
species,
Klebsiella
pneumoniae
Staphylococcus
aureus.
cytotoxicity
assay
carried
out
breast
cancer
cell
line
(MCF-7),
whereas
biocompatibility
test
performed
kidney
(293T).
Multiple
characterization
techniques
confirmed
successful
CTT-AuNPs.
average
size
19.1±2.2
nm.
results
revealed
showed
strong
S.
aureus
K.
pneumoniae,
which
further
live/dead
dual
staining
assay.
also
significantly
reduced
proliferation
MCF-7
cells
32.67%
at
120
µg/mL
after
24
hours
incubation.
These
green-synthesized
exhibited
excellent
cytobiocompatibility
with
293T
cells.
method
compared
chemically
AuNPs.
This
work
will
pave
way
for
production
biocompatible
can
be
different
disease
treatments.
Life,
Год журнала:
2025,
Номер
15(3), С. 406 - 406
Опубликована: Март 5, 2025
Berries
from
the
Vaccinium
genus,
known
for
their
rich
array
of
bioactive
metabolites,
are
recognized
antioxidant,
anti-inflammatory,
and
anticancer
properties.
These
compounds,
including
anthocyanins,
flavonoids,
phenolic
acids,
have
attracted
significant
attention
potential
health
benefits,
particularly
in
cancer
prevention
treatment.
Gastric
(GC),
a
leading
cause
cancer-related
deaths
worldwide,
remains
challenging
to
treat,
especially
its
advanced
stages.
This
study
investigates
therapeutic
species
GC
treatment
using
computational
methods.
RNA
sequencing
revealed
upregulated
genes
associated
with
GC,
while
network
pharmacology
molecular
docking
approaches
identified
strong
interactions
between
cyanidin
3-O-glucoside
(C3G),
key
metabolite.
Furthermore,
dynamics
simulations
HSP90AA1-C3G
complex
demonstrated
stable
binding
structural
integrity,
suggesting
that
C3G
may
inhibit
HSP90AA1,
protein
involved
progression.
findings
highlight
offering
novel
approach
by
targeting
pathways.
research
provides
valuable
insights
into
role
berries
as
natural
therapeutics,
supporting
integration
future
gastric
strategies.
Despite
progress
in
traditional
treatment
methods,
the
overall
survival
rate
for
oral
squamous
cell
carcinoma
(OSCC)
remains
limited.
Consequently,
it
is
essential
to
investigate
alternative
therapeutic
strategies
enhance
patient
outcomes.
This
review
highlights
potential
role
of
plant
extracts
as
chemo
preventive
agents
cancer
treatment.
A
systematic
was
conducted
following
PRISMA
guidelines,
involving
an
extensive
literature
search
from
databases
such
PubMed,
Scopus,
Embase,
Web
science,
Cochrane
and
CINAHL
which
included
studies
2010
2024
that
explored
anticancer
medicinal
plants
OSCC
Data
extraction
focused
on
species,
parts
used,
extract
type,
active
components,
dosage,
lines
or
animal
models
used.
Risk
bias
assessed
using
OHAT
tool
ROBINS-I
vitro
studies.
total
12
were
included,
examining
Allium
sativum
(garlic),
Crocus
sativus
(saffron),
Curcuma
longa
(turmeric),
Scutellariabaicalensis
(Baikal
skullcap),
etc.,
These
demonstrated
bioactive
components
like
allicin,
curcumin,
baicalin
significantly
inhibited
proliferation
induced
apoptosis.
However,
there
substantial
variability
dose
concentrations
required,
ranging
1
µg/mL
garlic
50
mg/mL
saffron
nanoparticles.
The
risk
assessment
indicated
four
had
a
moderate
risk,
while
one
low
bias,
indicating
methodological
rigor.
Plant
Vitis
vinifera
present
promising,
less
toxic
treatment,
with
be
integrated
into
conventional
chemotherapeutic
regimens.
While
in-vitro
are
encouraging,
further
clinical
trials
among
humans
necessary
confirm
their
efficacy
safety
settings.
Applied Sciences,
Год журнала:
2025,
Номер
15(6), С. 3251 - 3251
Опубликована: Март 17, 2025
Medicinal
plants
are
well-known
for
synthesizing
a
wide
range
of
bioactive
compounds
used
mainly
in
the
pharmaceutical,
food
and
cosmetic
industries.
The
therapeutic
use
Passiflora
species
Europe
began
17th
century,
but
few
studies
have
been
carried
out
on
caerulea
L.
This
is
versatile
plant,
an
herbaceous
climber,
belonging
to
Passifloraceae
family.
In
past,
P.
has
as
sedative
agent,
recent
years,
scientific
focused
exploring
its
functionality
pharmacological
use.
Phytochemical
analysis
revealed
several
classes
phytochemical
components,
some
which
promising
biological
potential.
Recent
confirmed
potential
by
demonstrating
vivo
anxiolytic
antistress
effects
well
antimicrobial,
antioxidant,
anticonvulsant,
analgesic
gastroprotective
activities.
While
these
findings
encouraging,
there
limited
research
conducted
profiling,
biosafety
molecular
mechanisms
activity
extracts
from
review
aims
summarize
analyze
data
activities
caerulea,
including
action
individual
applications.
