Vitamin E Improves Cellular and Structural Bone Histomorphometry in an Alcohol-Induced Osteoporosis Rat Model DOI Creative Commons
Norazlina Mohamed,

Seham Salem Ahmed Abukhadir,

Syed Alhafiz Syed Hashim

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1730 - 1730

Опубликована: Дек. 20, 2024

Background: Alcohol-induced osteoporosis is a significant health concern, impairing bone formation and enhancing resorption, thereby weakening skeletal integrity. This study examines the effects of palm vitamin E on histomorphometry in male rat model alcohol-induced osteoporosis. Methods: Three-month-old Sprague–Dawley rats were randomized into seven groups, with one baseline control group (BC) six experimental groups undergoing two-phase treatment. In first month, received normal saline, while intraperitoneal alcohol (3 g/kg) three times weekly. For subsequent two months, treatment continued (A), others olive oil (C), saline (AN), alpha-tocopherol (AA), or (AE) orally. Results: Femur histomorphometric analysis post-sacrifice showed that exposure significantly decreased osteoblastic activity impaired microarchitecture, evidenced by reduced Ob.S/BS, OS/BS, OV/BV, Tb.Th, BV/TV, Tb.N, alongside increased Oc.S/BS, ES/BS, Tb.Sp. Both improved parameters, showing superior efficacy except OV/BV. Conclusions: These findings suggest may offer therapeutic benefit for mitigating damage.

Язык: Английский

Vitamin E Improves Cellular and Structural Bone Histomorphometry in an Alcohol-Induced Osteoporosis Rat Model DOI Creative Commons
Norazlina Mohamed,

Seham Salem Ahmed Abukhadir,

Syed Alhafiz Syed Hashim

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1730 - 1730

Опубликована: Дек. 20, 2024

Background: Alcohol-induced osteoporosis is a significant health concern, impairing bone formation and enhancing resorption, thereby weakening skeletal integrity. This study examines the effects of palm vitamin E on histomorphometry in male rat model alcohol-induced osteoporosis. Methods: Three-month-old Sprague–Dawley rats were randomized into seven groups, with one baseline control group (BC) six experimental groups undergoing two-phase treatment. In first month, received normal saline, while intraperitoneal alcohol (3 g/kg) three times weekly. For subsequent two months, treatment continued (A), others olive oil (C), saline (AN), alpha-tocopherol (AA), or (AE) orally. Results: Femur histomorphometric analysis post-sacrifice showed that exposure significantly decreased osteoblastic activity impaired microarchitecture, evidenced by reduced Ob.S/BS, OS/BS, OV/BV, Tb.Th, BV/TV, Tb.N, alongside increased Oc.S/BS, ES/BS, Tb.Sp. Both improved parameters, showing superior efficacy except OV/BV. Conclusions: These findings suggest may offer therapeutic benefit for mitigating damage.

Язык: Английский

Процитировано

0