Journal of the American Oil Chemists Society,
Год журнала:
2023,
Номер
101(11), С. 1127 - 1132
Опубликована: Ноя. 10, 2023
Abstract
Branched‐chain
fatty
acids
(BCFAs)
have
recently
gained
increasing
attention
as
bioactive
lipids
with
potential
nutritional
properties
and
a
wide
array
of
applications
in
human
health.
The
current
study
reviews
the
most
recent
progress
BCFA
preparation.
An
overview
extraction
from
natural
sources,
including
lanolin
butter,
is
provided.
Further,
we
explore
how
clay
catalysts
zeolites
can
be
used
to
chemically
synthesize
BCFAs.
synthetic
BCFAs
are
mainly
isostearic
acids.
Some
bacterial
membranes
contain
high
proportion
been
studied
raw
materials
obtain
Engineering
microbial
production
also
reviewed.
Special
attentions
given
molecular
structure
during
different
preparation
methods.
Future
research
will
focus
on
obtaining
specific
structures
purity.
Nutrition Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Abstract
Branched-
chain
fatty
acids
(BCFAs)
are
a
category
of
saturated
that
commonly
present
in
various
organisms
and
play
crucial
role
variety
metabolic
reactions,
including
anticancer,
lipid-lowering,
anti-inflammatory,
neuroprotective
actions.
Currently,
there
is
growing
interest
the
relationship
between
BCFAs
obesity.
regulate
gene
expression
related
enzymes
by
activating
PPARα
sterol
regulatory
element-binding
protein-1c,
thereby
reducing
triglyceride
synthesis
body.
Additionally,
reduce
inflammation
decreasing
pro-inflammatory
factors
obesity
such
as
cyclooxygenase-2,
interleukin-6,
lipoxygenase-15
genes.
can
also
expedite
conversion
branched
amino
to
obesity-induced
insulin
resistance.
In
this
article
we
provide
comprehensive
review
research
progress
on
how
affect
from
perspectives
lipid
metabolism,
inflammation,
Computational and Structural Biotechnology Journal,
Год журнала:
2024,
Номер
23, С. 2163 - 2172
Опубликована: Май 8, 2024
Short-chain
fatty
acids
(SCFAs)
are
involved
in
important
physiological
processes
such
as
gut
health
and
immune
response,
changes
SCFA
levels
can
be
indicative
of
disease.
Despite
the
importance
SCFAs
human
disease,
reference
values
for
fecal
plasma
concentrations
healthy
individuals
scarce.
To
address
this
gap
current
knowledge,
we
developed
a
simple
reliable
derivatization-free
GC-TOFMS
method
quantifying
individuals.
We
targeted
six
linear-
seven
branched-SCFAs,
obtaining
recoveries
73-88%
83-134%
matrices,
respectively.
The
methods
simpler,
faster,
more
sensitive
than
previously
published
well
suited
large-scale
studies.
Analysis
samples
from
157
medically
confirmed
showed
that
total
feces
were
34.1
±
15.3
µmol/g
60.0
45.9
µM,
In
samples,
acetic
acid
(Ace),
propionic
(Pro),
butanoic
(But)
all
significant,
collectively
accounting
89%
SCFAs,
whereas
only
major
was
Ace,
constituting
93%
SCFAs.
There
no
statistically
significant
differences
between
sexes
or
among
age
groups.
data
revealed,
however,
positive
correlation
several
nutrients,
carbohydrate,
fat,
iron
vegetables,
water,
to
most
This
is
first
study
report
intervals
individuals,
thereby
delivers
valuable
microbiome,
metabolomics,
biomarker
research.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(17)
Опубликована: Фев. 23, 2024
Abstract
Veillonella
parvula
,
prototypical
member
of
the
oral
and
gut
microbiota,
is
at
times
commensal
yet
also
potentially
pathogenic.
The
definition
molecular
basis
tailoring
this
contrasting
behavior
key
for
broadening
our
understanding
microbiota‐driven
pathogenic
and/or
tolerogenic
mechanisms
that
take
place
within
body.
In
study,
we
focused
on
chemistry
main
constituent
outer
membrane
V.
lipopolysaccharide
(LPS).
LPS
molecules
indeed
elicit
pro‐inflammatory
immunomodulatory
responses
depending
their
chemical
structures.
Herein
report
structural
elucidation
from
two
strains
show
important
unprecedented
differences
in
both
lipid
carbohydrate
moieties,
including
identification
a
novel
galactofuranose
mannitol‐containing
O‐antigen
repeating
unit
one
strains.
Furthermore,
by
harnessing
computational
studies,
vitro
human
cell
models,
as
well
lectin
binding
solid‐phase
assays,
discovered
chemically
diverse
immunologically
behave
differently
have
attempted
to
identify
determinant(s)
governing
phenomenon.
Whereas
potential
has
been
evidenced
A
moiety,
contrast
plausible
“immune
modulating”
action
proposed
peculiar
portion.
Food & Function,
Год журнала:
2023,
Номер
15(3), С. 1071 - 1088
Опубликована: Дек. 18, 2023
The
biological
functions
of
fatty
acids
and
the
lipids
in
which
they
are
esterified
determined
by
their
chain
length,
double
bond
position
geometry
other
structural
motifs
such
as
presence
methyl
branches.
Unusual
isomeric
features
human
foods
conjugated
bonds
or
branching
found
dairy
products,
some
seeds
nuts,
marine
potentially
have
important
effects
on
health.
Recent
advancements
identifying
with
unusual
positions
pinpointing
branches
empowered
study
functions.
We
present
recent
advances
acid
elucidation
mass
spectrometry
comparison
more
traditional
methods.
can
be
purely
instrumental
methods,
specifically
solvent-mediated
covalent
adduct
chemical
ionization
(SM-CACI)
ozone
induced
dissociation
(OzID),
charge
inversion
methods
showing
promise.
Prior
derivatization
using
Paternò-Büchi
(PB)
reaction
to
yield
stable
structures
that,
upon
collisional
activation,
has
emerged.
(CI)
based
three
ion
monitoring
(MRM)
method
been
developed
simultaneously
identify
quantify
low-level
branched
(BCFAs),
unattainable
electron
(EI)
Accurate
identification
quantification
isomers
led
research
progress
discovery
biomarkers
for
cancer,
diabetes,
nonalcoholic
liver
disease
(NAFLD)
atherosclerosis.
Modulation
eicosanoids,
weight
loss
health
significance
BCFAs
also
presented.
This
review
clearly
shows
that
improvement
analytical
capacity
is
critical
functions,
stronger
coupling
discussed
here
mechanistic
promising
generating
refined
outcomes.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 17
Опубликована: Июль 30, 2024
Charting
out
personalized
and/or
optimized
diets
offers
new
opportunities
in
the
field
of
food
science,
although
with
inherent
challenges.
Starch-based
foods
are
a
major
component
daily
energy
intake
humans.
In
addition
to
being
rich
starch,
starchy
also
contain
multitude
bioactive
substances
(e.g.,
polyphenols,
lipids).
Food
processing
including
storage
affects
consistency
and
interactions
between
starch
other
components,
which
can
affect
quality
nutritional
characteristics
starch-based
foods.
This
review
describes
effects
components
on
structural
evolution
during
processing.
We
ponder
upon
how
molecular
structure
vis-a-vis
structure-property
relationship.
Furthermore,
we
formulate
best
practices
retain
value
by
rationally
designing
domains.
Interestingly,
found
that
inhibiting
formation
crystalline
structures
while
promoting
short-range
ordered
nano-aggregates
synchronously
slow
down
its
digestion
retrogradation
properties,
thus
improving
food.
provides
theoretical
guidelines
for
researchers
innovators
