Milk-Derived Extracellular Vesicles: A Novel Perspective on Comparative Therapeutics and Targeted Nanocarrier Application

Vaccines, Год журнала: 2024, Номер 12(11), С. 1282 - 1282

Опубликована: Ноя. 15, 2024

Milk-derived extracellular vesicles (mEVs) are emerging as promising therapeutic candidates due to their unique properties and versatile functions. These play a crucial role in immunomodulation by influencing macrophage differentiation cytokine production, potentially aiding the treatment of conditions such bone loss, fibrosis, cancer. mEVs also have capacity modulate gut microbiota composition, which may alleviate symptoms inflammatory bowel diseases promote intestinal barrier integrity. Their potential drug delivery vehicles is significant, enhancing stability, solubility, bioavailability anticancer agents while supporting wound healing reducing inflammation. Additionally, bovine exhibit anti-aging protect skin cells from UV damage. As vaccine platforms, offer advantages including biocompatibility, antigen protection, ability elicit robust immune responses through targeted specific cells. Despite these applications, challenges persist, complex roles cancer, effective loading, regulatory hurdles, need for standardized production methods. Achieving high targeting specificity understanding long-term effects mEV-based therapies essential clinical translation. Ongoing research aims optimize mEV methods, enhance capabilities, conduct rigorous preclinical studies. By addressing challenges, hold revolutionize development delivery, ultimately improving outcomes across various medical fields.

Язык: Английский

Milk-Derived Exosomes as Functional Nanocarriers in Wound Healing: Mechanisms, Applications, and Future Directions

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101715 - 101715

Опубликована: Март 1, 2025

Язык: Английский