Deciphering the Power of Resveratrol in Mitophagy: From Molecular Mechanisms to Therapeutic Applications

Phytotherapy Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 4, 2025

Resveratrol (RES), a natural polyphenolic compound, has garnered significant attention for its therapeutic potential in various pathological conditions. This review explores how RES modulates mitophagy-the selective autophagic degradation of mitochondria essential maintaining cellular homeostasis. promotes the initiation and execution mitophagy by enhancing PINK1/Parkin-mediated mitochondrial clearance, reducing reactive oxygen species production, mitigating apoptosis, thereby preserving integrity. Additionally, regulates through activation key molecular targets such as AMP-activated protein kinase (AMPK), mechanistic target rapamycin (mTOR), deacetylases (SIRT1 SIRT3), quality control (MQC) pathways, demonstrating substantial effects multiple disease models. We provide detailed account biosynthetic pharmacokinetics, metabolic characteristics RES, focusing on role modulation implications medical applications. Potential adverse associated with clinical use are also discussed. Despite promising properties, application is limited issues bioavailability pharmacokinetic profiles. Future research should concentrate developing derivatives that precisely modulate mitophagy, unlocking new avenues therapy.

Язык: Английский

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Green Production Pathways, Instability, and Stability of Resveratrol: A Systematic Review

Journal of Food Biochemistry, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Resveratrol (RES) is a nonflavonoid polyphenolic compound present in various plant species. Extensive research has confirmed the diverse biological activities of RES, rendering it highly promising for multiple industries. However, its stability influenced by intrinsic factors, such as structure, and extrinsic including light exposure, oxygen elevated temperature, pH variations. RES also faces challenges related to low solubility, rapid metabolism, limited bioavailability, which impede application food medical sectors. The objective this study was provide comprehensive overview most up‐to‐date advancements green efficient production pathways evaluate instability strategies stabilization. mainly achieved through extraction biosynthesis. methods include deep eutectic solvent (DES) methods, ultrasound‐assisted, supercritical fluid (SFE), enzyme‐assisted technology. advantages disadvantages each method are compared paper. biosynthesis can produce high yield short period, use genetic engineering other techniques improve optimize brought possibility mass RES. More importantly, be stabilized or protected encapsulation, combined with natural compounds, structurally modified synthesized chemo‐enzymatic great significance food, medicine, clinical applications.

Язык: Английский

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Bushen Jianpi Tiaoxue Decoction (BJTD) ameliorates oxidative stress and apoptosis induced by uterus ageing through activation of the SIRT1/NRF2 pathway

Phytomedicine, Год журнала: 2024, Номер 136, С. 156288 - 156288

Опубликована: Ноя. 25, 2024

Язык: Английский

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Potential Transformation of Food Resveratrol: Mechanisms and Biological Impact

Molecules, Год журнала: 2025, Номер 30(3), С. 536 - 536

Опубликована: Янв. 24, 2025

Resveratrol is a naturally occurring phenolic compound found in foods like grapes, berries, and peanuts. It has attracted substantial interest for its potential human health benefits, including antioxidant anti-inflammatory effects. Research indicates that resveratrol may contribute to cardiovascular health, protect cognitive function, exhibit anticancer properties. However, various factors such as pH levels, exposure light, specific enzymes, metal ions can alter chemical structure, affecting biological activities. These reactions lead the formation of different metabolites polymers, which affect stability bioactivity resveratrol. This review examines transformation from natural sources consumption by humans. Additionally, we explore activities resulting compounds transformations.

Язык: Английский

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Physicochemical and rheological characteristics of commercial Greek-style yogurt enriched with Polygonum cuspidatum roots or the P. Cuspidatum β-cyclodextrin inclusion complex

Food Research International, Год журнала: 2025, Номер unknown, С. 115854 - 115854

Опубликована: Янв. 1, 2025

Язык: Английский

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Ternary composite nanoparticles to improve the water solubility and stability of resveratrol:Preparation, characterization and bioavailability

Food Chemistry, Год журнала: 2025, Номер 474, С. 143258 - 143258

Опубликована: Фев. 6, 2025

Язык: Английский

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Novel methods for extraction of monomeric phenols from plants and fruits with potential anti-obesity activity

Journal of Food Composition and Analysis, Год журнала: 2025, Номер unknown, С. 107383 - 107383

Опубликована: Фев. 1, 2025

Язык: Английский

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Encapsulation of DHA oils for better bioavailability: A review from the practical aspect

Journal of the American Oil Chemists Society, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Abstract DHA has unique functional properties in human health. Various recommendations to increase dietary intake have been proposed. However, there is a difference between and nutritional functions. Therefore, bioavailability crucial for the efficacy of intake. A proper delivery system can up 50%–150%. phospholipid triglyceride forms readily absorbed by body more than ethyl ester form. oil encapsulation attain better bioavailability, controlled release, masking taste odor, besides improving oxidative stability. The formation matrix which hidden inside wall materials. Wall materials such as whey protein concentrates are often preferred, multiple layers through molecular assembly pursued. In Forming right matrix, emulsification technologies applied designed where nanoemulsion or liposome‐type structures advantages. For an encapsulated powder product, spray drying developed alternative techniques give large space improvement, novel developments spray–freeze may offer various This review will bring practical picture subject including overall evaluation patent applications well summary/remarks future developments.

Язык: Английский

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o-Quinone trapping by stilbenoids

Food Chemistry, Год журнала: 2025, Номер 484, С. 144381 - 144381

Опубликована: Апрель 17, 2025

Язык: Английский

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Emerging Trends in Green Extraction Techniques, Chemical Modifications, and Drug Delivery Systems for Resveratrol

Antioxidants, Год журнала: 2025, Номер 14(6), С. 654 - 654

Опубликована: Май 29, 2025

Resveratrol is a naturally occurring phytoalexin found in red grapes, cocoa berries, and grape wine. This compound exhibits potent antioxidant, anti-inflammatory, anticancer properties. However, its clinical application significantly hindered by poor aqueous solubility rapid degradation at physiological pH, resulting extremely low systemic bioavailability. review explores three key aspects: green extraction methods for the efficient sustainable isolation of resveratrol; structure–activity relationship studies resveratrol derivatives to identify compounds with improved bioavailability therapeutic efficacy; advanced drug delivery systems enhance solubility, stability, achieve targeted tissue delivery. All these solutions collectively aim increase bioavailability, enabling development effective pharmaceutical formulations maximizing potential this promising compound. The summarize published last five years, highlighting innovative advancements extraction, structural modifications, strategies resveratrol.

Язык: Английский

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