Unveiling Pharmacological Mechanisms of Bombyx mori (Abresham), a Traditional Arabic Unani Medicine for Ischemic Heart Disease: An Integrative Molecular Simulation Study DOI Creative Commons
Doni Dermawan, Nasser Alotaiq

Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 295 - 295

Опубликована: Фев. 24, 2025

Background: Ischemic heart disease (IHD), a leading cause of cardiovascular morbidity and mortality, continues to challenge modern medicine. Bombyx mori (Abresham), traditional ingredient in Unani medicine, has shown promise health, but its molecular mechanisms remain poorly understood. Methods: To explore the therapeutic potential for IHD, an integrative simulation approach was applied. Network pharmacology employed identify most favorable target receptor disease. Molecular docking simulations evaluated binding affinities chemical protein-based compounds from selected receptor. dynamics (MD) confirmed stability these interactions under physiological conditions. Pharmacophore modeling identified key structural features critical bioactivity, while silico toxicity assessments safety profiles compounds. Results: Key bioactive mori, including Menaquinone-7, Quercetin, Behenic acid, showed strong with receptor, ACE2. The MD-based MM/PBSA calculations revealed free energy values Menaquinone-7 (−35.12 kcal/mol), Quercetin (−29.38 acid (−27.76 confirming their affinity. Protein-based compounds, such as Chorion class high-cysteine HCB protein 13 (−212.43 Bombyxin A-5 (−209.36 FMRFamide-related peptides (−198.93 also displayed promising affinities. In Conclusions: This study positions source agents IHD. Future work should focus on experimental validation computational findings through vitro vivo studies.

Язык: Английский

Dietary calcium carbonate supplementation prolonged larval development by increasing the moltinism of the lepidopteran model Bombyx mori DOI
Xiaoning Sun, Guang Wang, Zhangang Xiao

и другие.

Food Bioscience, Год журнала: 2025, Номер unknown, С. 105905 - 105905

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Ultrasound-Assisted Extraction of Phenolic Compounds from Tricosanthes cucumerina Leaves: Microencapsulation and Characterization DOI Open Access
Carlos Felipe Vendramini, Talita Aparecida Ferreira de Campos, Natallya Marques da Silva

и другие.

Processes, Год журнала: 2025, Номер 13(2), С. 397 - 397

Опубликована: Фев. 2, 2025

This study utilized the ultrasound-assisted extraction method to obtain an extract rich in phenolic compounds from leaves of Tricosanthes cucumerina. The optimization experimental design identified optimal conditions: a temperature 40 °C, duration 6.25 min, and amplitude 40%. Under these conditions, yielded highest levels compounds, measuring 262.54 mg GAE (gallic acid equivalent) per gram. Further analysis extracts using electrospray ionization mass spectrometry (ESI-MS) demonstrated that ultrasound increased availability bioactive such as p-coumaric acid, ferulic caffeic acid. resulting was microencapsulated with sodium alginate wall material then lyophilized enhance shelf life stability compounds. thermogravimetric confirmed microcapsules exhibited thermal stability, retaining their properties at temperatures up 250 °C. Additionally, Fourier-transform infrared spectroscopy (FTIR) scanning electron microscopy (SEM) analyses corroborated effectiveness encapsulation process. Consequently, T. cucumerina is promising alternative for incorporating into food products, nutraceuticals, cosmetics, thus benefiting consumers.

Язык: Английский

Процитировано

0
Unveiling Pharmacological Mechanisms of Bombyx mori (Abresham), a Traditional Arabic Unani Medicine for Ischemic Heart Disease: An Integrative Molecular Simulation Study DOI Creative Commons
Doni Dermawan, Nasser Alotaiq

Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 295 - 295

Опубликована: Фев. 24, 2025

Background: Ischemic heart disease (IHD), a leading cause of cardiovascular morbidity and mortality, continues to challenge modern medicine. Bombyx mori (Abresham), traditional ingredient in Unani medicine, has shown promise health, but its molecular mechanisms remain poorly understood. Methods: To explore the therapeutic potential for IHD, an integrative simulation approach was applied. Network pharmacology employed identify most favorable target receptor disease. Molecular docking simulations evaluated binding affinities chemical protein-based compounds from selected receptor. dynamics (MD) confirmed stability these interactions under physiological conditions. Pharmacophore modeling identified key structural features critical bioactivity, while silico toxicity assessments safety profiles compounds. Results: Key bioactive mori, including Menaquinone-7, Quercetin, Behenic acid, showed strong with receptor, ACE2. The MD-based MM/PBSA calculations revealed free energy values Menaquinone-7 (−35.12 kcal/mol), Quercetin (−29.38 acid (−27.76 confirming their affinity. Protein-based compounds, such as Chorion class high-cysteine HCB protein 13 (−212.43 Bombyxin A-5 (−209.36 FMRFamide-related peptides (−198.93 also displayed promising affinities. In Conclusions: This study positions source agents IHD. Future work should focus on experimental validation computational findings through vitro vivo studies.

Язык: Английский

Процитировано

0